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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: BCKDK All Species: 27.58
Human Site: S85 Identified Species: 43.33
UniProt: O14874 Number Species: 14
    Phosphosite Substitution
    Charge Score: 0
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens O14874 NP_001116429.1 412 46360 S85 A G R S Q D G S H L L K S A R
Chimpanzee Pan troglodytes XP_001156184 412 46441 S85 A G R S Q D G S H L L K S A R
Rhesus Macaque Macaca mulatta XP_001112186 412 46391 S85 S G R S Q D G S H L L K S A R
Dog Lupus familis
Cat Felis silvestris
Mouse Mus musculus O55028 412 46569 S85 S G R S Q D G S H L L K S G R
Rat Rattus norvegicus Q00972 412 46456 S85 S G R S Q D G S H L L K S G R
Wallaby Macropus eugenll
Platypus Ornith. anatinus XP_001511214 371 41647 L79 R L T P T T M L Y S G R S Q D
Chicken Gallus gallus
Frog Xenopus laevis NP_001085012 413 47032 S85 S G R S Q D G S H I L K S A R
Zebra Danio Brachydanio rerio NP_998225 419 46906 Q93 A G K S P D G Q H I L S S A R
Tiger Blowfish Takifugu rubipres
Fruit Fly Dros. melanogaster P91622 413 46608 S87 R S V S E V S S W Y V K S F E
Honey Bee Apis mellifera
Nematode Worm Caenorhab. elegans Q02332 401 45263 S79 K L L Q M P S S K M V S N W Y
Sea Urchin Strong. purpuratus XP_780213 418 46942 N90 T G K S P D G N H L L R S A Q
Poplar Tree Populus trichocarpa XP_002314330 369 41691 S76 E T L P Y G L S E K P A V L K
Maize Zea mays NP_001105608 364 41356 S72 D S L P F G L S N K P A I L K
Rice Oryza sativa
Thale Cress Arabidopsis thaliana NP_187300 366 41428 G74 E L Q T L P Y G L S D K P A V
Baker's Yeast Sacchar. cerevisiae P40530 394 45425 T80 E Y M L T I K T I N L L L S L
Red Bread Mold Neurospora crassa
Conservation
Percent
Protein Identity: 100 99.7 98 N.A. N.A. 95.1 95.6 N.A. 73.3 N.A. 82 75.8 N.A. 22.7 N.A. 24.5 61.2
Protein Similarity: 100 99.7 98.5 N.A. N.A. 96.8 96.5 N.A. 78.4 N.A. 89.8 84.4 N.A. 39.7 N.A. 42.4 74.8
P-Site Identity: 100 100 93.3 N.A. N.A. 86.6 86.6 N.A. 6.6 N.A. 86.6 66.6 N.A. 26.6 N.A. 6.6 60
P-Site Similarity: 100 100 100 N.A. N.A. 93.3 93.3 N.A. 20 N.A. 100 80 N.A. 40 N.A. 26.6 86.6
Percent
Protein Identity: 32.2 33.5 N.A. 31.8 25.7 N.A.
Protein Similarity: 51.7 53.1 N.A. 50.9 47.5 N.A.
P-Site Identity: 6.6 6.6 N.A. 13.3 6.6 N.A.
P-Site Similarity: 13.3 20 N.A. 26.6 20 N.A.
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 20 0 0 0 0 0 0 0 0 0 0 14 0 47 0 % A
% Cys: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % C
% Asp: 7 0 0 0 0 54 0 0 0 0 7 0 0 0 7 % D
% Glu: 20 0 0 0 7 0 0 0 7 0 0 0 0 0 7 % E
% Phe: 0 0 0 0 7 0 0 0 0 0 0 0 0 7 0 % F
% Gly: 0 54 0 0 0 14 54 7 0 0 7 0 0 14 0 % G
% His: 0 0 0 0 0 0 0 0 54 0 0 0 0 0 0 % H
% Ile: 0 0 0 0 0 7 0 0 7 14 0 0 7 0 0 % I
% Lys: 7 0 14 0 0 0 7 0 7 14 0 54 0 0 14 % K
% Leu: 0 20 20 7 7 0 14 7 7 40 60 7 7 14 7 % L
% Met: 0 0 7 0 7 0 7 0 0 7 0 0 0 0 0 % M
% Asn: 0 0 0 0 0 0 0 7 7 7 0 0 7 0 0 % N
% Pro: 0 0 0 20 14 14 0 0 0 0 14 0 7 0 0 % P
% Gln: 0 0 7 7 40 0 0 7 0 0 0 0 0 7 7 % Q
% Arg: 14 0 40 0 0 0 0 0 0 0 0 14 0 0 47 % R
% Ser: 27 14 0 60 0 0 14 67 0 14 0 14 67 7 0 % S
% Thr: 7 7 7 7 14 7 0 7 0 0 0 0 0 0 0 % T
% Val: 0 0 7 0 0 7 0 0 0 0 14 0 7 0 7 % V
% Trp: 0 0 0 0 0 0 0 0 7 0 0 0 0 7 0 % W
% Tyr: 0 7 0 0 7 0 7 0 7 7 0 0 0 0 7 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _