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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: IKBKB All Species: 37.58
Human Site: S474 Identified Species: 82.67
UniProt: O14920 Number Species: 10
    Phosphosite Substitution
    Charge Score: 0.1
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens O14920 NP_001547.1 756 86564 S474 K M K N S M A S M S Q Q L K A
Chimpanzee Pan troglodytes XP_528121 757 86974 S474 K M K N S M A S M S Q Q L K A
Rhesus Macaque Macaca mulatta XP_001096913 756 86591 S474 K M K N S M A S M S Q Q L K A
Dog Lupus familis XP_539954 755 86445 S474 K M K N S M A S M S Q Q L K A
Cat Felis silvestris
Mouse Mus musculus O88351 757 86672 S474 K M K N A M A S T A Q Q L K A
Rat Rattus norvegicus Q9QY78 757 86848 S474 K M K N A M A S T A Q Q L K A
Wallaby Macropus eugenll
Platypus Ornith. anatinus XP_001509921 757 87360 S474 K M K N S M A S M S Q Q L K A
Chicken Gallus gallus Q5ZJB4 759 86125 S485 K M K N N M V S A S Q Q L K A
Frog Xenopus laevis Q6GM53 743 85134 S469 K M K N T M V S A S Q Q L D A
Zebra Danio Brachydanio rerio Q4G3H4 758 87129 S472 R Y K N M M F S F S Q Q L K A
Tiger Blowfish Takifugu rubipres
Fruit Fly Dros. melanogaster Q9VEZ5 751 86354 E492 M L Y V L T K E Q A R Y E M L
Honey Bee Apis mellifera
Nematode Worm Caenorhab. elegans
Sea Urchin Strong. purpuratus
Poplar Tree Populus trichocarpa
Maize Zea mays
Rice Oryza sativa
Thale Cress Arabidopsis thaliana
Baker's Yeast Sacchar. cerevisiae
Red Bread Mold Neurospora crassa
Conservation
Percent
Protein Identity: 100 97.4 99.7 94.9 N.A. 91.8 91.2 N.A. 88.5 49.2 50.4 51.5 N.A. 25 N.A. N.A. N.A.
Protein Similarity: 100 98.4 99.7 97 N.A. 95.5 95.3 N.A. 92.7 67.8 68.3 67.9 N.A. 42.8 N.A. N.A. N.A.
P-Site Identity: 100 100 100 100 N.A. 80 80 N.A. 100 80 73.3 66.6 N.A. 0 N.A. N.A. N.A.
P-Site Similarity: 100 100 100 100 N.A. 93.3 93.3 N.A. 100 86.6 80 73.3 N.A. 20 N.A. N.A. N.A.
Percent
Protein Identity: N.A. N.A. N.A. N.A. N.A. N.A.
Protein Similarity: N.A. N.A. N.A. N.A. N.A. N.A.
P-Site Identity: N.A. N.A. N.A. N.A. N.A. N.A.
P-Site Similarity: N.A. N.A. N.A. N.A. N.A. N.A.
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 0 0 0 0 19 0 64 0 19 28 0 0 0 0 91 % A
% Cys: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % C
% Asp: 0 0 0 0 0 0 0 0 0 0 0 0 0 10 0 % D
% Glu: 0 0 0 0 0 0 0 10 0 0 0 0 10 0 0 % E
% Phe: 0 0 0 0 0 0 10 0 10 0 0 0 0 0 0 % F
% Gly: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % G
% His: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % H
% Ile: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % I
% Lys: 82 0 91 0 0 0 10 0 0 0 0 0 0 82 0 % K
% Leu: 0 10 0 0 10 0 0 0 0 0 0 0 91 0 10 % L
% Met: 10 82 0 0 10 91 0 0 46 0 0 0 0 10 0 % M
% Asn: 0 0 0 91 10 0 0 0 0 0 0 0 0 0 0 % N
% Pro: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % P
% Gln: 0 0 0 0 0 0 0 0 10 0 91 91 0 0 0 % Q
% Arg: 10 0 0 0 0 0 0 0 0 0 10 0 0 0 0 % R
% Ser: 0 0 0 0 46 0 0 91 0 73 0 0 0 0 0 % S
% Thr: 0 0 0 0 10 10 0 0 19 0 0 0 0 0 0 % T
% Val: 0 0 0 10 0 0 19 0 0 0 0 0 0 0 0 % V
% Trp: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % W
% Tyr: 0 10 10 0 0 0 0 0 0 0 0 10 0 0 0 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _