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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
CASK
All Species:
22.73
Human Site:
Y321
Identified Species:
41.67
UniProt:
O14936
Number Species:
12
Phosphosite Substitution
Charge Score:
0.08
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
O14936
NP_001119526.1
926
105123
Y321
S
H
K
F
N
S
F
Y
G
D
P
P
E
E
L
Chimpanzee
Pan troglodytes
Rhesus Macaque
Macaca mulatta
XP_001095837
1264
140995
Y659
S
H
K
F
N
S
F
Y
G
D
P
P
E
E
L
Dog
Lupus familis
XP_850618
926
105060
Y321
S
H
K
F
N
S
F
Y
G
D
P
P
E
E
L
Cat
Felis silvestris
Mouse
Mus musculus
O70589
926
105090
Y321
S
H
K
F
N
S
F
Y
G
D
P
P
E
E
L
Rat
Rattus norvegicus
Q62915
909
103240
Y321
S
H
K
F
N
S
F
Y
G
D
P
P
E
E
L
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001512873
955
108509
Y355
S
H
K
F
N
S
F
Y
G
D
P
P
E
E
L
Chicken
Gallus gallus
Q5ZJ00
468
52501
Frog
Xenopus laevis
Q9DG02
475
53914
Zebra Danio
Brachydanio rerio
NP_694420
920
104302
H315
V
L
A
A
V
S
S
H
K
F
N
S
F
Y
G
Tiger Blowfish
Takifugu rubipres
P49697
467
52590
Fruit Fly
Dros. melanogaster
Q24210
898
100893
G315
A
V
Q
A
I
A
G
G
T
N
M
D
P
L
Y
Honey Bee
Apis mellifera
XP_394821
897
101840
A313
L
K
D
A
V
K
V
A
I
S
S
S
K
W
H
Nematode Worm
Caenorhab. elegans
P54936
961
108794
D345
D
G
S
S
P
G
G
D
C
C
H
R
G
E
S
Sea Urchin
Strong. purpuratus
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Baker's Yeast
Sacchar. cerevisiae
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
N.A.
73.2
99.8
N.A.
99.8
97.7
N.A.
94.5
33
25.5
93.5
32.7
62
66.4
42.9
N.A.
Protein Similarity:
100
N.A.
73.2
99.8
N.A.
100
97.9
N.A.
95.5
42.7
36
96.2
42
77
78.6
62.1
N.A.
P-Site Identity:
100
N.A.
100
100
N.A.
100
100
N.A.
100
0
0
6.6
0
0
0
6.6
N.A.
P-Site Similarity:
100
N.A.
100
100
N.A.
100
100
N.A.
100
0
0
13.3
0
26.6
6.6
6.6
N.A.
Percent
Protein Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
8
0
8
24
0
8
0
8
0
0
0
0
0
0
0
% A
% Cys:
0
0
0
0
0
0
0
0
8
8
0
0
0
0
0
% C
% Asp:
8
0
8
0
0
0
0
8
0
47
0
8
0
0
0
% D
% Glu:
0
0
0
0
0
0
0
0
0
0
0
0
47
54
0
% E
% Phe:
0
0
0
47
0
0
47
0
0
8
0
0
8
0
0
% F
% Gly:
0
8
0
0
0
8
16
8
47
0
0
0
8
0
8
% G
% His:
0
47
0
0
0
0
0
8
0
0
8
0
0
0
8
% H
% Ile:
0
0
0
0
8
0
0
0
8
0
0
0
0
0
0
% I
% Lys:
0
8
47
0
0
8
0
0
8
0
0
0
8
0
0
% K
% Leu:
8
8
0
0
0
0
0
0
0
0
0
0
0
8
47
% L
% Met:
0
0
0
0
0
0
0
0
0
0
8
0
0
0
0
% M
% Asn:
0
0
0
0
47
0
0
0
0
8
8
0
0
0
0
% N
% Pro:
0
0
0
0
8
0
0
0
0
0
47
47
8
0
0
% P
% Gln:
0
0
8
0
0
0
0
0
0
0
0
0
0
0
0
% Q
% Arg:
0
0
0
0
0
0
0
0
0
0
0
8
0
0
0
% R
% Ser:
47
0
8
8
0
54
8
0
0
8
8
16
0
0
8
% S
% Thr:
0
0
0
0
0
0
0
0
8
0
0
0
0
0
0
% T
% Val:
8
8
0
0
16
0
8
0
0
0
0
0
0
0
0
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
8
0
% W
% Tyr:
0
0
0
0
0
0
0
47
0
0
0
0
0
8
8
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _