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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: PLD2 All Species: 4.24
Human Site: S493 Identified Species: 9.33
UniProt: O14939 Number Species: 10
    Phosphosite Substitution
    Charge Score: -0.1
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens O14939 NP_002654.3 933 105987 S493 P P T P R P D S P A T P D L S
Chimpanzee Pan troglodytes XP_511291 924 105027 S493 P P T L C P D S P A T P D L S
Rhesus Macaque Macaca mulatta XP_001117754 892 101098 Y470 F F W L G K D Y S N L I T K D
Dog Lupus familis XP_536610 854 96426 R454 P A H S D D W R L D I M L K K
Cat Felis silvestris
Mouse Mus musculus P97813 933 106150 P493 T P T L G S D P A A T P D L S
Rat Rattus norvegicus P70498 933 106019 P493 T P T P G S D P A A T P D L S
Wallaby Macropus eugenll
Platypus Ornith. anatinus
Chicken Gallus gallus XP_422793 1072 123414 A513 S L S D L P D A R A L S L P S
Frog Xenopus laevis NP_001129642 1039 119219 I516 S T T A I N K I P S D P T L S
Zebra Danio Brachydanio rerio XP_694649 927 106849 C486 A S E P A S E C E D E V D L S
Tiger Blowfish Takifugu rubipres
Fruit Fly Dros. melanogaster
Honey Bee Apis mellifera
Nematode Worm Caenorhab. elegans
Sea Urchin Strong. purpuratus XP_001194932 825 94056 M425 E L P F E E T M D R S S V P R
Poplar Tree Populus trichocarpa
Maize Zea mays
Rice Oryza sativa
Thale Cress Arabidopsis thaliana Q9M9W8 1046 118792 P528 Y N P R E S E P N S W E E T M
Baker's Yeast Sacchar. cerevisiae
Red Bread Mold Neurospora crassa
Conservation
Percent
Protein Identity: 100 96.4 92.1 77.2 N.A. 90 89.5 N.A. N.A. 48.8 50.9 59.2 N.A. N.A. N.A. N.A. 36.2
Protein Similarity: 100 97.2 93.7 80.7 N.A. 93.8 93.1 N.A. N.A. 63.3 66.2 73.5 N.A. N.A. N.A. N.A. 53.1
P-Site Identity: 100 86.6 6.6 6.6 N.A. 60 66.6 N.A. N.A. 26.6 33.3 26.6 N.A. N.A. N.A. N.A. 0
P-Site Similarity: 100 86.6 6.6 6.6 N.A. 60 66.6 N.A. N.A. 40 40 33.3 N.A. N.A. N.A. N.A. 6.6
Percent
Protein Identity: N.A. N.A. N.A. 31.2 N.A. N.A.
Protein Similarity: N.A. N.A. N.A. 48.9 N.A. N.A.
P-Site Identity: N.A. N.A. N.A. 0 N.A. N.A.
P-Site Similarity: N.A. N.A. N.A. 20 N.A. N.A.
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 10 10 0 10 10 0 0 10 19 46 0 0 0 0 0 % A
% Cys: 0 0 0 0 10 0 0 10 0 0 0 0 0 0 0 % C
% Asp: 0 0 0 10 10 10 55 0 10 19 10 0 46 0 10 % D
% Glu: 10 0 10 0 19 10 19 0 10 0 10 10 10 0 0 % E
% Phe: 10 10 0 10 0 0 0 0 0 0 0 0 0 0 0 % F
% Gly: 0 0 0 0 28 0 0 0 0 0 0 0 0 0 0 % G
% His: 0 0 10 0 0 0 0 0 0 0 0 0 0 0 0 % H
% Ile: 0 0 0 0 10 0 0 10 0 0 10 10 0 0 0 % I
% Lys: 0 0 0 0 0 10 10 0 0 0 0 0 0 19 10 % K
% Leu: 0 19 0 28 10 0 0 0 10 0 19 0 19 55 0 % L
% Met: 0 0 0 0 0 0 0 10 0 0 0 10 0 0 10 % M
% Asn: 0 10 0 0 0 10 0 0 10 10 0 0 0 0 0 % N
% Pro: 28 37 19 28 0 28 0 28 28 0 0 46 0 19 0 % P
% Gln: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % Q
% Arg: 0 0 0 10 10 0 0 10 10 10 0 0 0 0 10 % R
% Ser: 19 10 10 10 0 37 0 19 10 19 10 19 0 0 64 % S
% Thr: 19 10 46 0 0 0 10 0 0 0 37 0 19 10 0 % T
% Val: 0 0 0 0 0 0 0 0 0 0 0 10 10 0 0 % V
% Trp: 0 0 10 0 0 0 10 0 0 0 10 0 0 0 0 % W
% Tyr: 10 0 0 0 0 0 0 10 0 0 0 0 0 0 0 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _