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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: HGS All Species: 21.21
Human Site: T716 Identified Species: 42.42
UniProt: O14964 Number Species: 11
    Phosphosite Substitution
    Charge Score: -0.09
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens O14964 NP_004703.1 777 86192 T716 Y N M Q N L M T T L P S Q D A
Chimpanzee Pan troglodytes XP_511742 777 85768 T716 Y N M Q N L M T A L P S Q D A
Rhesus Macaque Macaca mulatta XP_001111673 777 86015 T716 Y N M Q N L M T T L P S Q D A
Dog Lupus familis XP_540486 782 86005 T720 Y G M Q S L M T T L P S Q D A
Cat Felis silvestris
Mouse Mus musculus Q99LI8 775 85996 T714 Y N M Q N L M T A L P G Q D A
Rat Rattus norvegicus Q9JJ50 776 86228 T715 Y N M Q N L M T T L P G Q D A
Wallaby Macropus eugenll
Platypus Ornith. anatinus
Chicken Gallus gallus
Frog Xenopus laevis NP_001083588 751 84100 G693 N F M S T L P G Q D P S L S S
Zebra Danio Brachydanio rerio
Tiger Blowfish Takifugu rubipres
Fruit Fly Dros. melanogaster Q960X8 760 85396 Q687 Q I P G Q Q P Q Q I P V Q Q P
Honey Bee Apis mellifera XP_393989 830 92147 P691 N Q I P H T I P Q V P Q S H M
Nematode Worm Caenorhab. elegans
Sea Urchin Strong. purpuratus XP_783582 784 87687 G713 Y N M Q A V T G A L P Q G Q V
Poplar Tree Populus trichocarpa
Maize Zea mays
Rice Oryza sativa
Thale Cress Arabidopsis thaliana
Baker's Yeast Sacchar. cerevisiae P40343 622 70927 R571 G E T S I N K R P Q G I T R Y
Red Bread Mold Neurospora crassa Q7RZJ2 724 79729 H673 P Q Q P Y W Q H S A A Q Q T P
Conservation
Percent
Protein Identity: 100 95.5 98.8 92.3 N.A. 93.3 93.4 N.A. N.A. N.A. 80 N.A. N.A. 41.7 47.7 N.A. 49.4
Protein Similarity: 100 96.6 98.9 94.2 N.A. 95.6 95.6 N.A. N.A. N.A. 87.5 N.A. N.A. 55.7 60.9 N.A. 61.3
P-Site Identity: 100 93.3 100 86.6 N.A. 86.6 93.3 N.A. N.A. N.A. 26.6 N.A. N.A. 13.3 6.6 N.A. 40
P-Site Similarity: 100 93.3 100 93.3 N.A. 86.6 93.3 N.A. N.A. N.A. 33.3 N.A. N.A. 20 33.3 N.A. 46.6
Percent
Protein Identity: N.A. N.A. N.A. N.A. 21.2 24.9
Protein Similarity: N.A. N.A. N.A. N.A. 40.6 41
P-Site Identity: N.A. N.A. N.A. N.A. 0 6.6
P-Site Similarity: N.A. N.A. N.A. N.A. 0 13.3
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 0 0 0 0 9 0 0 0 25 9 9 0 0 0 50 % A
% Cys: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % C
% Asp: 0 0 0 0 0 0 0 0 0 9 0 0 0 50 0 % D
% Glu: 0 9 0 0 0 0 0 0 0 0 0 0 0 0 0 % E
% Phe: 0 9 0 0 0 0 0 0 0 0 0 0 0 0 0 % F
% Gly: 9 9 0 9 0 0 0 17 0 0 9 17 9 0 0 % G
% His: 0 0 0 0 9 0 0 9 0 0 0 0 0 9 0 % H
% Ile: 0 9 9 0 9 0 9 0 0 9 0 9 0 0 0 % I
% Lys: 0 0 0 0 0 0 9 0 0 0 0 0 0 0 0 % K
% Leu: 0 0 0 0 0 59 0 0 0 59 0 0 9 0 0 % L
% Met: 0 0 67 0 0 0 50 0 0 0 0 0 0 0 9 % M
% Asn: 17 50 0 0 42 9 0 0 0 0 0 0 0 0 0 % N
% Pro: 9 0 9 17 0 0 17 9 9 0 84 0 0 0 17 % P
% Gln: 9 17 9 59 9 9 9 9 25 9 0 25 67 17 0 % Q
% Arg: 0 0 0 0 0 0 0 9 0 0 0 0 0 9 0 % R
% Ser: 0 0 0 17 9 0 0 0 9 0 0 42 9 9 9 % S
% Thr: 0 0 9 0 9 9 9 50 34 0 0 0 9 9 0 % T
% Val: 0 0 0 0 0 9 0 0 0 9 0 9 0 0 9 % V
% Trp: 0 0 0 0 0 9 0 0 0 0 0 0 0 0 0 % W
% Tyr: 59 0 0 0 9 0 0 0 0 0 0 0 0 0 9 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _