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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
AURKA
All Species:
31.52
Human Site:
Y148
Identified Species:
46.22
UniProt:
O14965
Number Species:
15
Phosphosite Substitution
Charge Score:
-0.13
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
O14965
NP_003591.2
403
45809
Y148
K
G
K
F
G
N
V
Y
L
A
R
E
K
Q
S
Chimpanzee
Pan troglodytes
XP_525364
403
45791
Y148
K
G
K
F
G
N
V
Y
L
A
R
E
K
Q
S
Rhesus Macaque
Macaca mulatta
XP_001098364
471
52859
Y220
K
G
K
F
G
N
V
Y
L
A
R
L
K
E
S
Dog
Lupus familis
XP_853397
405
45606
Y149
K
G
K
F
G
N
V
Y
L
A
R
E
K
Q
S
Cat
Felis silvestris
Mouse
Mus musculus
P97477
395
44754
Y139
K
G
K
F
G
N
V
Y
L
A
R
E
R
Q
S
Rat
Rattus norvegicus
P59241
397
44856
Y141
K
G
K
F
G
N
V
Y
L
A
R
E
K
Q
S
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001521399
303
34973
A71
F
K
G
Q
L
E
K
A
G
V
E
H
Q
L
R
Chicken
Gallus gallus
XP_425725
409
46456
Y162
K
G
K
F
G
N
V
Y
L
A
R
E
K
Q
S
Frog
Xenopus laevis
Q91819
408
46443
Y155
K
G
K
F
G
N
V
Y
L
A
R
E
R
E
S
Zebra Danio
Brachydanio rerio
Q6NW76
320
36928
Q88
L
K
V
L
F
K
S
Q
M
V
K
E
G
V
E
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
Q9VKN7
329
38282
R96
L
R
K
G
C
V
Q
R
Q
V
L
R
E
I
E
Honey Bee
Apis mellifera
XP_395732
327
37711
L95
F
I
I
A
M
K
V
L
F
K
A
Q
I
Q
K
Nematode Worm
Caenorhab. elegans
O01427
305
34731
H73
L
I
S
G
G
V
E
H
Q
L
E
R
E
I
E
Sea Urchin
Strong. purpuratus
XP_001181990
278
32048
K46
L
F
K
S
Q
L
Q
K
A
Q
V
E
H
Q
L
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Q683C9
282
32738
L50
H
I
V
A
L
K
V
L
F
K
A
Q
L
Q
Q
Baker's Yeast
Sacchar. cerevisiae
P38991
367
42927
M135
Y
I
C
A
L
K
V
M
E
K
E
E
I
I
K
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
100
47.7
89.8
N.A.
82.6
83.6
N.A.
65.5
73.1
65.9
53.3
N.A.
38.4
53
46.6
50.6
Protein Similarity:
100
100
62.2
93
N.A.
86.8
87.3
N.A.
70.2
82.8
77.2
65.7
N.A.
57.8
67
56.3
60
P-Site Identity:
100
100
86.6
100
N.A.
93.3
100
N.A.
0
100
86.6
6.6
N.A.
6.6
13.3
6.6
20
P-Site Similarity:
100
100
93.3
100
N.A.
100
100
N.A.
6.6
100
100
20
N.A.
13.3
20
20
20
Percent
Protein Identity:
N.A.
N.A.
N.A.
46.4
38.9
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
55.3
57.5
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
13.3
13.3
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
20
13.3
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
0
0
19
0
0
0
7
7
50
13
0
0
0
0
% A
% Cys:
0
0
7
0
7
0
0
0
0
0
0
0
0
0
0
% C
% Asp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% D
% Glu:
0
0
0
0
0
7
7
0
7
0
19
63
13
13
19
% E
% Phe:
13
7
0
50
7
0
0
0
13
0
0
0
0
0
0
% F
% Gly:
0
50
7
13
57
0
0
0
7
0
0
0
7
0
0
% G
% His:
7
0
0
0
0
0
0
7
0
0
0
7
7
0
0
% H
% Ile:
0
25
7
0
0
0
0
0
0
0
0
0
13
19
0
% I
% Lys:
50
13
63
0
0
25
7
7
0
19
7
0
38
0
13
% K
% Leu:
25
0
0
7
19
7
0
13
50
7
7
7
7
7
7
% L
% Met:
0
0
0
0
7
0
0
7
7
0
0
0
0
0
0
% M
% Asn:
0
0
0
0
0
50
0
0
0
0
0
0
0
0
0
% N
% Pro:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% P
% Gln:
0
0
0
7
7
0
13
7
13
7
0
13
7
57
7
% Q
% Arg:
0
7
0
0
0
0
0
7
0
0
50
13
13
0
7
% R
% Ser:
0
0
7
7
0
0
7
0
0
0
0
0
0
0
50
% S
% Thr:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% T
% Val:
0
0
13
0
0
13
69
0
0
19
7
0
0
7
0
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
7
0
0
0
0
0
0
50
0
0
0
0
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _