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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: XPO1 All Species: 27.27
Human Site: S160 Identified Species: 54.55
UniProt: O14980 Number Species: 11
    Phosphosite Substitution
    Charge Score: 0.09
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens O14980 NP_003391.1 1071 123386 S160 I V G A S R T S E S L C Q N N
Chimpanzee Pan troglodytes XP_001161222 1071 123367 S160 I V G A S R T S E S L C Q N N
Rhesus Macaque Macaca mulatta
Dog Lupus familis XP_531839 1071 123123 S160 I V G A S R T S E S L C Q N N
Cat Felis silvestris
Mouse Mus musculus Q6P5F9 1071 123074 S160 I V G A S R T S E S L C Q N N
Rat Rattus norvegicus Q80U96 1071 123020 S160 I V G A S R T S E S L C Q N N
Wallaby Macropus eugenll
Platypus Ornith. anatinus XP_001512501 1059 121040 L151 A S R T S E S L C Q N N M V I
Chicken Gallus gallus XP_001231648 1071 123138 S160 I V G A S R T S E S L C Q N N
Frog Xenopus laevis NP_001083734 1071 123149 S160 I V G A S R T S E S L C Q N N
Zebra Danio Brachydanio rerio
Tiger Blowfish Takifugu rubipres
Fruit Fly Dros. melanogaster Q9TVM2 1063 122781 N157 I V G A S K T N E S L C M N N
Honey Bee Apis mellifera XP_396469 1062 122406 N155 I V G A S K T N E S L C Q N N
Nematode Worm Caenorhab. elegans
Sea Urchin Strong. purpuratus XP_780879 1068 122315 N155 I V G A S K T N E S L C Q N N
Poplar Tree Populus trichocarpa
Maize Zea mays
Rice Oryza sativa
Thale Cress Arabidopsis thaliana
Baker's Yeast Sacchar. cerevisiae P30822 1084 124086 E153 S S S V N V C E N N M I V L K
Red Bread Mold Neurospora crassa
Conservation
Percent
Protein Identity: 100 99.9 N.A. 98.8 N.A. 98 97.8 N.A. 95.5 98.5 97 N.A. N.A. 70.7 76.4 N.A. 81
Protein Similarity: 100 100 N.A. 99.2 N.A. 98.7 98.7 N.A. 96.1 99.1 98.4 N.A. N.A. 83 86.9 N.A. 89.5
P-Site Identity: 100 100 N.A. 100 N.A. 100 100 N.A. 6.6 100 100 N.A. N.A. 80 86.6 N.A. 86.6
P-Site Similarity: 100 100 N.A. 100 N.A. 100 100 N.A. 13.3 100 100 N.A. N.A. 93.3 100 N.A. 100
Percent
Protein Identity: N.A. N.A. N.A. N.A. 47.2 N.A.
Protein Similarity: N.A. N.A. N.A. N.A. 67.1 N.A.
P-Site Identity: N.A. N.A. N.A. N.A. 0 N.A.
P-Site Similarity: N.A. N.A. N.A. N.A. 20 N.A.
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 9 0 0 84 0 0 0 0 0 0 0 0 0 0 0 % A
% Cys: 0 0 0 0 0 0 9 0 9 0 0 84 0 0 0 % C
% Asp: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % D
% Glu: 0 0 0 0 0 9 0 9 84 0 0 0 0 0 0 % E
% Phe: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % F
% Gly: 0 0 84 0 0 0 0 0 0 0 0 0 0 0 0 % G
% His: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % H
% Ile: 84 0 0 0 0 0 0 0 0 0 0 9 0 0 9 % I
% Lys: 0 0 0 0 0 25 0 0 0 0 0 0 0 0 9 % K
% Leu: 0 0 0 0 0 0 0 9 0 0 84 0 0 9 0 % L
% Met: 0 0 0 0 0 0 0 0 0 0 9 0 17 0 0 % M
% Asn: 0 0 0 0 9 0 0 25 9 9 9 9 0 84 84 % N
% Pro: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % P
% Gln: 0 0 0 0 0 0 0 0 0 9 0 0 75 0 0 % Q
% Arg: 0 0 9 0 0 59 0 0 0 0 0 0 0 0 0 % R
% Ser: 9 17 9 0 92 0 9 59 0 84 0 0 0 0 0 % S
% Thr: 0 0 0 9 0 0 84 0 0 0 0 0 0 0 0 % T
% Val: 0 84 0 9 0 9 0 0 0 0 0 0 9 9 0 % V
% Trp: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % W
% Tyr: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _