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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: SETD1A All Species: 9.39
Human Site: S1033 Identified Species: 15.9
UniProt: O15047 Number Species: 13
    Phosphosite Substitution
    Charge Score: -0.08
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens O15047 NP_055527.1 1707 186034 S1033 E N D S T S D S E S S S S S S
Chimpanzee Pan troglodytes XP_523492 1707 185692 S1033 E N D S T S D S E S S S S S S
Rhesus Macaque Macaca mulatta
Dog Lupus familis XP_848999 1330 145541 V721 E P G L L S L V D W A K S G G
Cat Felis silvestris
Mouse Mus musculus Q8CFT2 1985 215333 E1165 S E S S G S S E F E S S S E S
Rat Rattus norvegicus
Wallaby Macropus eugenll
Platypus Ornith. anatinus XP_001506028 1287 141359 P678 P P L P P S P P P A P G P E R
Chicken Gallus gallus Q5F3P8 2008 223067 E1091 E E E Q D S E E E D A A S P S
Frog Xenopus laevis Q66J90 1938 216239 V1046 E E E D I T S V A S S R A E M
Zebra Danio Brachydanio rerio Q1LY77 1844 204122 V1088 D E E E V V E V K A P S T P T
Tiger Blowfish Takifugu rubipres
Fruit Fly Dros. melanogaster NP_001015221 1641 188364 K988 E N V T K R T K K N I Y S D T
Honey Bee Apis mellifera XP_395451 1406 159180 R797 L T E L A I Q R S L D C P T P
Nematode Worm Caenorhab. elegans Q18221 1507 171664 S898 Q R T V S T S S S S S S A A T
Sea Urchin Strong. purpuratus XP_791552 1963 220543 G1255 A F G M E G L G L G L R A N M
Poplar Tree Populus trichocarpa
Maize Zea mays
Rice Oryza sativa
Thale Cress Arabidopsis thaliana
Baker's Yeast Sacchar. cerevisiae P38827 1080 123894 S471 I A H A Q T C S N A E S G N L
Red Bread Mold Neurospora crassa Q8X0S9 1313 145607 R704 D V S T L R V R K L K S R G V
Conservation
Percent
Protein Identity: 100 99.5 N.A. 73.2 N.A. 37 N.A. N.A. 27.7 34.5 34.1 36.7 N.A. 25.6 24.6 20.9 23.7
Protein Similarity: 100 99.5 N.A. 74.7 N.A. 49.5 N.A. N.A. 38.7 47.5 48.6 50.7 N.A. 41.3 39.6 35.8 39.2
P-Site Identity: 100 100 N.A. 20 N.A. 40 N.A. N.A. 6.6 33.3 20 6.6 N.A. 20 0 26.6 0
P-Site Similarity: 100 100 N.A. 33.3 N.A. 40 N.A. N.A. 13.3 60 40 53.3 N.A. 46.6 13.3 66.6 13.3
Percent
Protein Identity: N.A. N.A. N.A. N.A. 21.7 22.2
Protein Similarity: N.A. N.A. N.A. N.A. 33.8 36.5
P-Site Identity: N.A. N.A. N.A. N.A. 13.3 6.6
P-Site Similarity: N.A. N.A. N.A. N.A. 40 26.6
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 8 8 0 8 8 0 0 0 8 22 15 8 22 8 0 % A
% Cys: 0 0 0 0 0 0 8 0 0 0 0 8 0 0 0 % C
% Asp: 15 0 15 8 8 0 15 0 8 8 8 0 0 8 0 % D
% Glu: 43 29 29 8 8 0 15 15 22 8 8 0 0 22 0 % E
% Phe: 0 8 0 0 0 0 0 0 8 0 0 0 0 0 0 % F
% Gly: 0 0 15 0 8 8 0 8 0 8 0 8 8 15 8 % G
% His: 0 0 8 0 0 0 0 0 0 0 0 0 0 0 0 % H
% Ile: 8 0 0 0 8 8 0 0 0 0 8 0 0 0 0 % I
% Lys: 0 0 0 0 8 0 0 8 22 0 8 8 0 0 0 % K
% Leu: 8 0 8 15 15 0 15 0 8 15 8 0 0 0 8 % L
% Met: 0 0 0 8 0 0 0 0 0 0 0 0 0 0 15 % M
% Asn: 0 22 0 0 0 0 0 0 8 8 0 0 0 15 0 % N
% Pro: 8 15 0 8 8 0 8 8 8 0 15 0 15 15 8 % P
% Gln: 8 0 0 8 8 0 8 0 0 0 0 0 0 0 0 % Q
% Arg: 0 8 0 0 0 15 0 15 0 0 0 15 8 0 8 % R
% Ser: 8 0 15 22 8 43 22 29 15 29 36 50 43 15 29 % S
% Thr: 0 8 8 15 15 22 8 0 0 0 0 0 8 8 22 % T
% Val: 0 8 8 8 8 8 8 22 0 0 0 0 0 0 8 % V
% Trp: 0 0 0 0 0 0 0 0 0 8 0 0 0 0 0 % W
% Tyr: 0 0 0 0 0 0 0 0 0 0 0 8 0 0 0 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _