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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: SETD1A All Species: 12.12
Human Site: S1036 Identified Species: 20.51
UniProt: O15047 Number Species: 13
    Phosphosite Substitution
    Charge Score: 0.08
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens O15047 NP_055527.1 1707 186034 S1036 S T S D S E S S S S S S S S S
Chimpanzee Pan troglodytes XP_523492 1707 185692 S1036 S T S D S E S S S S S S S S S
Rhesus Macaque Macaca mulatta
Dog Lupus familis XP_848999 1330 145541 A724 L L S L V D W A K S G G T T G
Cat Felis silvestris
Mouse Mus musculus Q8CFT2 1985 215333 S1168 S G S S E F E S S S E S E S S
Rat Rattus norvegicus
Wallaby Macropus eugenll
Platypus Ornith. anatinus XP_001506028 1287 141359 P681 P P S P P P A P G P E R L P V
Chicken Gallus gallus Q5F3P8 2008 223067 A1094 Q D S E E E D A A S P S S S K
Frog Xenopus laevis Q66J90 1938 216239 S1049 D I T S V A S S R A E M D S S
Zebra Danio Brachydanio rerio Q1LY77 1844 204122 P1091 E V V E V K A P S T P T G P P
Tiger Blowfish Takifugu rubipres
Fruit Fly Dros. melanogaster NP_001015221 1641 188364 I991 T K R T K K N I Y S D T D E D
Honey Bee Apis mellifera XP_395451 1406 159180 D800 L A I Q R S L D C P T P T G R
Nematode Worm Caenorhab. elegans Q18221 1507 171664 S901 V S T S S S S S S A A T S A R
Sea Urchin Strong. purpuratus XP_791552 1963 220543 L1258 M E G L G L G L R A N M P R M
Poplar Tree Populus trichocarpa
Maize Zea mays
Rice Oryza sativa
Thale Cress Arabidopsis thaliana
Baker's Yeast Sacchar. cerevisiae P38827 1080 123894 E474 A Q T C S N A E S G N L T I M
Red Bread Mold Neurospora crassa Q8X0S9 1313 145607 K707 T L R V R K L K S R G V N A R
Conservation
Percent
Protein Identity: 100 99.5 N.A. 73.2 N.A. 37 N.A. N.A. 27.7 34.5 34.1 36.7 N.A. 25.6 24.6 20.9 23.7
Protein Similarity: 100 99.5 N.A. 74.7 N.A. 49.5 N.A. N.A. 38.7 47.5 48.6 50.7 N.A. 41.3 39.6 35.8 39.2
P-Site Identity: 100 100 N.A. 13.3 N.A. 53.3 N.A. N.A. 6.6 40 26.6 6.6 N.A. 6.6 0 33.3 0
P-Site Similarity: 100 100 N.A. 40 N.A. 53.3 N.A. N.A. 13.3 60 40 40 N.A. 33.3 13.3 73.3 13.3
Percent
Protein Identity: N.A. N.A. N.A. N.A. 21.7 22.2
Protein Similarity: N.A. N.A. N.A. N.A. 33.8 36.5
P-Site Identity: N.A. N.A. N.A. N.A. 13.3 6.6
P-Site Similarity: N.A. N.A. N.A. N.A. 46.6 33.3
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 8 8 0 0 0 8 22 15 8 22 8 0 0 15 0 % A
% Cys: 0 0 0 8 0 0 0 0 8 0 0 0 0 0 0 % C
% Asp: 8 8 0 15 0 8 8 8 0 0 8 0 15 0 8 % D
% Glu: 8 8 0 15 15 22 8 8 0 0 22 0 8 8 0 % E
% Phe: 0 0 0 0 0 8 0 0 0 0 0 0 0 0 0 % F
% Gly: 0 8 8 0 8 0 8 0 8 8 15 8 8 8 8 % G
% His: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % H
% Ile: 0 8 8 0 0 0 0 8 0 0 0 0 0 8 0 % I
% Lys: 0 8 0 0 8 22 0 8 8 0 0 0 0 0 8 % K
% Leu: 15 15 0 15 0 8 15 8 0 0 0 8 8 0 0 % L
% Met: 8 0 0 0 0 0 0 0 0 0 0 15 0 0 15 % M
% Asn: 0 0 0 0 0 8 8 0 0 0 15 0 8 0 0 % N
% Pro: 8 8 0 8 8 8 0 15 0 15 15 8 8 15 8 % P
% Gln: 8 8 0 8 0 0 0 0 0 0 0 0 0 0 0 % Q
% Arg: 0 0 15 0 15 0 0 0 15 8 0 8 0 8 22 % R
% Ser: 22 8 43 22 29 15 29 36 50 43 15 29 29 36 29 % S
% Thr: 15 15 22 8 0 0 0 0 0 8 8 22 22 8 0 % T
% Val: 8 8 8 8 22 0 0 0 0 0 0 8 0 0 8 % V
% Trp: 0 0 0 0 0 0 8 0 0 0 0 0 0 0 0 % W
% Tyr: 0 0 0 0 0 0 0 0 8 0 0 0 0 0 0 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _