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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: SETD1A All Species: 10.91
Human Site: S1054 Identified Species: 18.46
UniProt: O15047 Number Species: 13
    Phosphosite Substitution
    Charge Score: 0.08
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens O15047 NP_055527.1 1707 186034 S1054 S S S S S S S S S S S S E S S
Chimpanzee Pan troglodytes XP_523492 1707 185692 S1054 S S S S S S S S S S S S E S S
Rhesus Macaque Macaca mulatta
Dog Lupus familis XP_848999 1330 145541 R742 F A F G S G L R G A L R L P S
Cat Felis silvestris
Mouse Mus musculus Q8CFT2 1985 215333 T1186 S E D E E E M T V P G V E E E
Rat Rattus norvegicus
Wallaby Macropus eugenll
Platypus Ornith. anatinus XP_001506028 1287 141359 P699 P P P E E E P P R T P G R V V
Chicken Gallus gallus Q5F3P8 2008 223067 D1112 E S S D E S E D S S E F E S S
Frog Xenopus laevis Q66J90 1938 216239 S1067 D E S S E Y E S S S D S D D E
Zebra Danio Brachydanio rerio Q1LY77 1844 204122 L1109 E P N E L G R L E A V D E A E
Tiger Blowfish Takifugu rubipres
Fruit Fly Dros. melanogaster NP_001015221 1641 188364 E1009 T L F P A L K E K N I S T I L
Honey Bee Apis mellifera XP_395451 1406 159180 D818 I P N I K I K D V N S N E F P
Nematode Worm Caenorhab. elegans Q18221 1507 171664 T919 D E S D S D S T P G E V Q R R
Sea Urchin Strong. purpuratus XP_791552 1963 220543 S1276 K V K R K A A S P S P N D E V
Poplar Tree Populus trichocarpa
Maize Zea mays
Rice Oryza sativa
Thale Cress Arabidopsis thaliana
Baker's Yeast Sacchar. cerevisiae P38827 1080 123894 K492 R R I P I L I K F H L I L P R
Red Bread Mold Neurospora crassa Q8X0S9 1313 145607 A725 F N D P F A R A R P T Q R V D
Conservation
Percent
Protein Identity: 100 99.5 N.A. 73.2 N.A. 37 N.A. N.A. 27.7 34.5 34.1 36.7 N.A. 25.6 24.6 20.9 23.7
Protein Similarity: 100 99.5 N.A. 74.7 N.A. 49.5 N.A. N.A. 38.7 47.5 48.6 50.7 N.A. 41.3 39.6 35.8 39.2
P-Site Identity: 100 100 N.A. 13.3 N.A. 13.3 N.A. N.A. 0 53.3 40 6.6 N.A. 6.6 13.3 20 13.3
P-Site Similarity: 100 100 N.A. 26.6 N.A. 20 N.A. N.A. 6.6 53.3 46.6 26.6 N.A. 26.6 33.3 33.3 40
Percent
Protein Identity: N.A. N.A. N.A. N.A. 21.7 22.2
Protein Similarity: N.A. N.A. N.A. N.A. 33.8 36.5
P-Site Identity: N.A. N.A. N.A. N.A. 0 0
P-Site Similarity: N.A. N.A. N.A. N.A. 0 26.6
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 0 8 0 0 8 15 8 8 0 15 0 0 0 8 0 % A
% Cys: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % C
% Asp: 15 0 15 15 0 8 0 15 0 0 8 8 15 8 8 % D
% Glu: 15 22 0 22 29 15 15 8 8 0 15 0 43 15 22 % E
% Phe: 15 0 15 0 8 0 0 0 8 0 0 8 0 8 0 % F
% Gly: 0 0 0 8 0 15 0 0 8 8 8 8 0 0 0 % G
% His: 0 0 0 0 0 0 0 0 0 8 0 0 0 0 0 % H
% Ile: 8 0 8 8 8 8 8 0 0 0 8 8 0 8 0 % I
% Lys: 8 0 8 0 15 0 15 8 8 0 0 0 0 0 0 % K
% Leu: 0 8 0 0 8 15 8 8 0 0 15 0 15 0 8 % L
% Met: 0 0 0 0 0 0 8 0 0 0 0 0 0 0 0 % M
% Asn: 0 8 15 0 0 0 0 0 0 15 0 15 0 0 0 % N
% Pro: 8 22 8 22 0 0 8 8 15 15 15 0 0 15 8 % P
% Gln: 0 0 0 0 0 0 0 0 0 0 0 8 8 0 0 % Q
% Arg: 8 8 0 8 0 0 15 8 15 0 0 8 15 8 15 % R
% Ser: 22 22 36 22 29 22 22 29 29 36 22 29 0 22 29 % S
% Thr: 8 0 0 0 0 0 0 15 0 8 8 0 8 0 0 % T
% Val: 0 8 0 0 0 0 0 0 15 0 8 15 0 15 15 % V
% Trp: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % W
% Tyr: 0 0 0 0 0 8 0 0 0 0 0 0 0 0 0 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _