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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: SETD1A All Species: 4.55
Human Site: S1114 Identified Species: 7.69
UniProt: O15047 Number Species: 13
    Phosphosite Substitution
    Charge Score: 0.38
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens O15047 NP_055527.1 1707 186034 S1114 P L P E Q E A S P A R P A G P
Chimpanzee Pan troglodytes XP_523492 1707 185692 S1114 P L P E Q E A S P A R P A G P
Rhesus Macaque Macaca mulatta
Dog Lupus familis XP_848999 1330 145541 D802 G T K P P K R D E E R S K T Q
Cat Felis silvestris
Mouse Mus musculus Q8CFT2 1985 215333 L1246 R G P M R E S L G T E E E V D
Rat Rattus norvegicus
Wallaby Macropus eugenll
Platypus Ornith. anatinus XP_001506028 1287 141359 R759 L S G G G V P R T P G R D F S
Chicken Gallus gallus Q5F3P8 2008 223067 E1172 E L P D D K R E T I L E L Y P
Frog Xenopus laevis Q66J90 1938 216239 A1127 E C S S P V K A E A D M E L E
Zebra Danio Brachydanio rerio Q1LY77 1844 204122 N1169 A S L E E V G N L R P P T P T
Tiger Blowfish Takifugu rubipres
Fruit Fly Dros. melanogaster NP_001015221 1641 188364 E1069 P P G Y N E E E I K K K V D C
Honey Bee Apis mellifera XP_395451 1406 159180 E878 E T K N V E D E V Q K K I K N
Nematode Worm Caenorhab. elegans Q18221 1507 171664 D979 M K Q E E T A D E K S R K R K
Sea Urchin Strong. purpuratus XP_791552 1963 220543 E1336 P Q V L D R R E R A K R A R E
Poplar Tree Populus trichocarpa
Maize Zea mays
Rice Oryza sativa
Thale Cress Arabidopsis thaliana
Baker's Yeast Sacchar. cerevisiae P38827 1080 123894 L552 H V D I K K R L I G P T V F D
Red Bread Mold Neurospora crassa Q8X0S9 1313 145607 G785 D R N K E E T G S W V A G E D
Conservation
Percent
Protein Identity: 100 99.5 N.A. 73.2 N.A. 37 N.A. N.A. 27.7 34.5 34.1 36.7 N.A. 25.6 24.6 20.9 23.7
Protein Similarity: 100 99.5 N.A. 74.7 N.A. 49.5 N.A. N.A. 38.7 47.5 48.6 50.7 N.A. 41.3 39.6 35.8 39.2
P-Site Identity: 100 100 N.A. 6.6 N.A. 13.3 N.A. N.A. 0 20 6.6 13.3 N.A. 13.3 6.6 13.3 20
P-Site Similarity: 100 100 N.A. 13.3 N.A. 26.6 N.A. N.A. 0 33.3 13.3 26.6 N.A. 20 13.3 20 26.6
Percent
Protein Identity: N.A. N.A. N.A. N.A. 21.7 22.2
Protein Similarity: N.A. N.A. N.A. N.A. 33.8 36.5
P-Site Identity: N.A. N.A. N.A. N.A. 0 6.6
P-Site Similarity: N.A. N.A. N.A. N.A. 20 20
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 8 0 0 0 0 0 22 8 0 29 0 8 22 0 0 % A
% Cys: 0 8 0 0 0 0 0 0 0 0 0 0 0 0 8 % C
% Asp: 8 0 8 8 15 0 8 15 0 0 8 0 8 8 22 % D
% Glu: 22 0 0 29 22 43 8 29 22 8 8 15 15 8 15 % E
% Phe: 0 0 0 0 0 0 0 0 0 0 0 0 0 15 0 % F
% Gly: 8 8 15 8 8 0 8 8 8 8 8 0 8 15 0 % G
% His: 8 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % H
% Ile: 0 0 0 8 0 0 0 0 15 8 0 0 8 0 0 % I
% Lys: 0 8 15 8 8 22 8 0 0 15 22 15 15 8 8 % K
% Leu: 8 22 8 8 0 0 0 15 8 0 8 0 8 8 0 % L
% Met: 8 0 0 8 0 0 0 0 0 0 0 8 0 0 0 % M
% Asn: 0 0 8 8 8 0 0 8 0 0 0 0 0 0 8 % N
% Pro: 29 8 29 8 15 0 8 0 15 8 15 22 0 8 22 % P
% Gln: 0 8 8 0 15 0 0 0 0 8 0 0 0 0 8 % Q
% Arg: 8 8 0 0 8 8 29 8 8 8 22 22 0 15 0 % R
% Ser: 0 15 8 8 0 0 8 15 8 0 8 8 0 0 8 % S
% Thr: 0 15 0 0 0 8 8 0 15 8 0 8 8 8 8 % T
% Val: 0 8 8 0 8 22 0 0 8 0 8 0 15 8 0 % V
% Trp: 0 0 0 0 0 0 0 0 0 8 0 0 0 0 0 % W
% Tyr: 0 0 0 8 0 0 0 0 0 0 0 0 0 8 0 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _