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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: SETD1A All Species: 6.06
Human Site: S1152 Identified Species: 10.26
UniProt: O15047 Number Species: 13
    Phosphosite Substitution
    Charge Score: -0.08
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens O15047 NP_055527.1 1707 186034 S1152 P R P D E R P S S P I P L L P
Chimpanzee Pan troglodytes XP_523492 1707 185692 S1152 P C P D E R P S S P I P L L P
Rhesus Macaque Macaca mulatta
Dog Lupus familis XP_848999 1330 145541 S831 E A S Q E S S S E K K R R K T
Cat Felis silvestris
Mouse Mus musculus Q8CFT2 1985 215333 P1357 L R P P S P P P E P E T P E P
Rat Rattus norvegicus
Wallaby Macropus eugenll
Platypus Ornith. anatinus XP_001506028 1287 141359 P788 P A G P L P C P Q K P L G E E
Chicken Gallus gallus Q5F3P8 2008 223067 A1314 V K T K L P S A V E E E D R L
Frog Xenopus laevis Q66J90 1938 216239 S1346 G R D I L V K S S H L G K S Q
Zebra Danio Brachydanio rerio Q1LY77 1844 204122 P1225 P T P S M H L P L P P S H V P
Tiger Blowfish Takifugu rubipres
Fruit Fly Dros. melanogaster NP_001015221 1641 188364 K1102 K E Y Q E R R K R N T E Y M A
Honey Bee Apis mellifera XP_395451 1406 159180 E907 K M E N S A A E A L I T L A G
Nematode Worm Caenorhab. elegans Q18221 1507 171664 R1008 A T S V V S S R Q S S L E P Q
Sea Urchin Strong. purpuratus XP_791552 1963 220543 E1401 D E E E E D E E L E V I M K E
Poplar Tree Populus trichocarpa
Maize Zea mays
Rice Oryza sativa
Thale Cress Arabidopsis thaliana
Baker's Yeast Sacchar. cerevisiae P38827 1080 123894 R581 E L K E K E K R Q Q I A S K I
Red Bread Mold Neurospora crassa Q8X0S9 1313 145607 L814 A L L K K R K L D L P A E T A
Conservation
Percent
Protein Identity: 100 99.5 N.A. 73.2 N.A. 37 N.A. N.A. 27.7 34.5 34.1 36.7 N.A. 25.6 24.6 20.9 23.7
Protein Similarity: 100 99.5 N.A. 74.7 N.A. 49.5 N.A. N.A. 38.7 47.5 48.6 50.7 N.A. 41.3 39.6 35.8 39.2
P-Site Identity: 100 93.3 N.A. 13.3 N.A. 33.3 N.A. N.A. 6.6 0 20 26.6 N.A. 13.3 13.3 0 6.6
P-Site Similarity: 100 93.3 N.A. 13.3 N.A. 33.3 N.A. N.A. 6.6 13.3 26.6 33.3 N.A. 20 26.6 0 26.6
Percent
Protein Identity: N.A. N.A. N.A. N.A. 21.7 22.2
Protein Similarity: N.A. N.A. N.A. N.A. 33.8 36.5
P-Site Identity: N.A. N.A. N.A. N.A. 6.6 6.6
P-Site Similarity: N.A. N.A. N.A. N.A. 20 13.3
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 15 15 0 0 0 8 8 8 8 0 0 15 0 8 15 % A
% Cys: 0 8 0 0 0 0 8 0 0 0 0 0 0 0 0 % C
% Asp: 8 0 8 15 0 8 0 0 8 0 0 0 8 0 0 % D
% Glu: 15 15 15 15 36 8 8 15 15 15 15 15 15 15 15 % E
% Phe: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % F
% Gly: 8 0 8 0 0 0 0 0 0 0 0 8 8 0 8 % G
% His: 0 0 0 0 0 8 0 0 0 8 0 0 8 0 0 % H
% Ile: 0 0 0 8 0 0 0 0 0 0 29 8 0 0 8 % I
% Lys: 15 8 8 15 15 0 22 8 0 15 8 0 8 22 0 % K
% Leu: 8 15 8 0 22 0 8 8 15 15 8 15 22 15 8 % L
% Met: 0 8 0 0 8 0 0 0 0 0 0 0 8 8 0 % M
% Asn: 0 0 0 8 0 0 0 0 0 8 0 0 0 0 0 % N
% Pro: 29 0 29 15 0 22 22 22 0 29 22 15 8 8 29 % P
% Gln: 0 0 0 15 0 0 0 0 22 8 0 0 0 0 15 % Q
% Arg: 0 22 0 0 0 29 8 15 8 0 0 8 8 8 0 % R
% Ser: 0 0 15 8 15 15 22 29 22 8 8 8 8 8 0 % S
% Thr: 0 15 8 0 0 0 0 0 0 0 8 15 0 8 8 % T
% Val: 8 0 0 8 8 8 0 0 8 0 8 0 0 8 0 % V
% Trp: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % W
% Tyr: 0 0 8 0 0 0 0 0 0 0 0 0 8 0 0 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _