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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: SETD1A All Species: 6.06
Human Site: S1382 Identified Species: 10.26
UniProt: O15047 Number Species: 13
    Phosphosite Substitution
    Charge Score: 0.23
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens O15047 NP_055527.1 1707 186034 S1382 E S S D S S S S S D G E G A L
Chimpanzee Pan troglodytes XP_523492 1707 185692 S1382 E S S D S S S S S D G E G A L
Rhesus Macaque Macaca mulatta
Dog Lupus familis XP_848999 1330 145541 G1025 P L P H R A G G A T P A P S P
Cat Felis silvestris
Mouse Mus musculus Q8CFT2 1985 215333 L1654 V T E E Y V D L A K V R G P W
Rat Rattus norvegicus
Wallaby Macropus eugenll
Platypus Ornith. anatinus XP_001506028 1287 141359 D982 A A A L P S P D Y S P R R P L
Chicken Gallus gallus Q5F3P8 2008 223067 N1670 K E L E N Q W N E D F K E E E
Frog Xenopus laevis Q66J90 1938 216239 E1603 Q W N E V L K E E E E D I S K
Zebra Danio Brachydanio rerio Q1LY77 1844 204122 L1465 T L I E A S S L P E L P V N N
Tiger Blowfish Takifugu rubipres
Fruit Fly Dros. melanogaster NP_001015221 1641 188364 M1301 K R D L A P R M S N V K S K M
Honey Bee Apis mellifera XP_395451 1406 159180 S1101 Y K E R D L M S E M A I L Y E
Nematode Worm Caenorhab. elegans Q18221 1507 171664 E1202 T F K P R S E E E K K K I I G
Sea Urchin Strong. purpuratus XP_791552 1963 220543 T1609 G D Y K T L L T K Q L K I V L
Poplar Tree Populus trichocarpa
Maize Zea mays
Rice Oryza sativa
Thale Cress Arabidopsis thaliana
Baker's Yeast Sacchar. cerevisiae P38827 1080 123894 L775 I K D E E D M L I L K Q L L S
Red Bread Mold Neurospora crassa Q8X0S9 1313 145607 P1008 I G T L K L V P F H G E D G P
Conservation
Percent
Protein Identity: 100 99.5 N.A. 73.2 N.A. 37 N.A. N.A. 27.7 34.5 34.1 36.7 N.A. 25.6 24.6 20.9 23.7
Protein Similarity: 100 99.5 N.A. 74.7 N.A. 49.5 N.A. N.A. 38.7 47.5 48.6 50.7 N.A. 41.3 39.6 35.8 39.2
P-Site Identity: 100 100 N.A. 0 N.A. 6.6 N.A. N.A. 13.3 6.6 0 13.3 N.A. 6.6 6.6 6.6 6.6
P-Site Similarity: 100 100 N.A. 20 N.A. 26.6 N.A. N.A. 26.6 40 40 33.3 N.A. 40 6.6 13.3 26.6
Percent
Protein Identity: N.A. N.A. N.A. N.A. 21.7 22.2
Protein Similarity: N.A. N.A. N.A. N.A. 33.8 36.5
P-Site Identity: N.A. N.A. N.A. N.A. 0 13.3
P-Site Similarity: N.A. N.A. N.A. N.A. 13.3 20
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 8 8 8 0 15 8 0 0 15 0 8 8 0 15 0 % A
% Cys: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % C
% Asp: 0 8 15 15 8 8 8 8 0 22 0 8 8 0 0 % D
% Glu: 15 8 15 36 8 0 8 15 29 15 8 22 8 8 15 % E
% Phe: 0 8 0 0 0 0 0 0 8 0 8 0 0 0 0 % F
% Gly: 8 8 0 0 0 0 8 8 0 0 22 0 22 8 8 % G
% His: 0 0 0 8 0 0 0 0 0 8 0 0 0 0 0 % H
% Ile: 15 0 8 0 0 0 0 0 8 0 0 8 22 8 0 % I
% Lys: 15 15 8 8 8 0 8 0 8 15 15 29 0 8 8 % K
% Leu: 0 15 8 22 0 29 8 22 0 8 15 0 15 8 29 % L
% Met: 0 0 0 0 0 0 15 8 0 8 0 0 0 0 8 % M
% Asn: 0 0 8 0 8 0 0 8 0 8 0 0 0 8 8 % N
% Pro: 8 0 8 8 8 8 8 8 8 0 15 8 8 15 15 % P
% Gln: 8 0 0 0 0 8 0 0 0 8 0 8 0 0 0 % Q
% Arg: 0 8 0 8 15 0 8 0 0 0 0 15 8 0 0 % R
% Ser: 0 15 15 0 15 36 22 22 22 8 0 0 8 15 8 % S
% Thr: 15 8 8 0 8 0 0 8 0 8 0 0 0 0 0 % T
% Val: 8 0 0 0 8 8 8 0 0 0 15 0 8 8 0 % V
% Trp: 0 8 0 0 0 0 8 0 0 0 0 0 0 0 8 % W
% Tyr: 8 0 8 0 8 0 0 0 8 0 0 0 0 8 0 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _