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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: SETD1A All Species: 10.61
Human Site: S343 Identified Species: 17.95
UniProt: O15047 Number Species: 13
    Phosphosite Substitution
    Charge Score: 0
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens O15047 NP_055527.1 1707 186034 S343 S S S A S S S S L S S S S S S
Chimpanzee Pan troglodytes XP_523492 1707 185692 S343 S S S A S S S S L S S S S S S
Rhesus Macaque Macaca mulatta
Dog Lupus familis XP_848999 1330 145541 Y87 K F K L D E F Y I G Q I P L K
Cat Felis silvestris
Mouse Mus musculus Q8CFT2 1985 215333 T351 S S D L S F G T V G S S G T P
Rat Rattus norvegicus
Wallaby Macropus eugenll
Platypus Ornith. anatinus XP_001506028 1287 141359 P44 T S A A V L A P T I P M P P P
Chicken Gallus gallus Q5F3P8 2008 223067 F402 P Y Q A P A V F P Q S E E Q P
Frog Xenopus laevis Q66J90 1938 216239 F369 P Q A E T V Q F P R T P P L S
Zebra Danio Brachydanio rerio Q1LY77 1844 204122 S388 H Q P P E P P S P A F T H T P
Tiger Blowfish Takifugu rubipres
Fruit Fly Dros. melanogaster NP_001015221 1641 188364 R345 E S F R D R K R S H E K G R D
Honey Bee Apis mellifera XP_395451 1406 159180 E163 Q K F G A V E E L I V Y Y H P
Nematode Worm Caenorhab. elegans Q18221 1507 171664 G264 N T Y E D E G G M L S G V I M
Sea Urchin Strong. purpuratus XP_791552 1963 220543 Y409 Q S S M K Q N Y M A R S E S H
Poplar Tree Populus trichocarpa
Maize Zea mays
Rice Oryza sativa
Thale Cress Arabidopsis thaliana
Baker's Yeast Sacchar. cerevisiae P38827 1080 123894
Red Bread Mold Neurospora crassa Q8X0S9 1313 145607 H70 G A S P G R S H I T S L N H S
Conservation
Percent
Protein Identity: 100 99.5 N.A. 73.2 N.A. 37 N.A. N.A. 27.7 34.5 34.1 36.7 N.A. 25.6 24.6 20.9 23.7
Protein Similarity: 100 99.5 N.A. 74.7 N.A. 49.5 N.A. N.A. 38.7 47.5 48.6 50.7 N.A. 41.3 39.6 35.8 39.2
P-Site Identity: 100 100 N.A. 0 N.A. 33.3 N.A. N.A. 13.3 13.3 6.6 6.6 N.A. 6.6 6.6 6.6 26.6
P-Site Similarity: 100 100 N.A. 6.6 N.A. 53.3 N.A. N.A. 33.3 20 26.6 26.6 N.A. 6.6 13.3 26.6 46.6
Percent
Protein Identity: N.A. N.A. N.A. N.A. 21.7 22.2
Protein Similarity: N.A. N.A. N.A. N.A. 33.8 36.5
P-Site Identity: N.A. N.A. N.A. N.A. 0 26.6
P-Site Similarity: N.A. N.A. N.A. N.A. 0 53.3
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 0 8 15 29 8 8 8 0 0 15 0 0 0 0 0 % A
% Cys: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % C
% Asp: 0 0 8 0 22 0 0 0 0 0 0 0 0 0 8 % D
% Glu: 8 0 0 15 8 15 8 8 0 0 8 8 15 0 0 % E
% Phe: 0 8 15 0 0 8 8 15 0 0 8 0 0 0 0 % F
% Gly: 8 0 0 8 8 0 15 8 0 15 0 8 15 0 0 % G
% His: 8 0 0 0 0 0 0 8 0 8 0 0 8 15 8 % H
% Ile: 0 0 0 0 0 0 0 0 15 15 0 8 0 8 0 % I
% Lys: 8 8 8 0 8 0 8 0 0 0 0 8 0 0 8 % K
% Leu: 0 0 0 15 0 8 0 0 22 8 0 8 0 15 0 % L
% Met: 0 0 0 8 0 0 0 0 15 0 0 8 0 0 8 % M
% Asn: 8 0 0 0 0 0 8 0 0 0 0 0 8 0 0 % N
% Pro: 15 0 8 15 8 8 8 8 22 0 8 8 22 8 36 % P
% Gln: 15 15 8 0 0 8 8 0 0 8 8 0 0 8 0 % Q
% Arg: 0 0 0 8 0 15 0 8 0 8 8 0 0 8 0 % R
% Ser: 22 43 29 0 22 15 22 22 8 15 43 29 15 22 29 % S
% Thr: 8 8 0 0 8 0 0 8 8 8 8 8 0 15 0 % T
% Val: 0 0 0 0 8 15 8 0 8 0 8 0 8 0 0 % V
% Trp: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % W
% Tyr: 0 8 8 0 0 0 0 15 0 0 0 8 8 0 0 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _