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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: SETD1A All Species: 16.97
Human Site: S915 Identified Species: 28.72
UniProt: O15047 Number Species: 13
    Phosphosite Substitution
    Charge Score: -0.15
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens O15047 NP_055527.1 1707 186034 S915 E E K R P R P S T P A E E D E
Chimpanzee Pan troglodytes XP_523492 1707 185692 S915 E E K R P R P S T P A E E D E
Rhesus Macaque Macaca mulatta
Dog Lupus familis XP_848999 1330 145541 S618 V A A E P L P S S S V S G E E
Cat Felis silvestris
Mouse Mus musculus Q8CFT2 1985 215333 S975 D Q K R L R P S T S V D E E D
Rat Rattus norvegicus
Wallaby Macropus eugenll
Platypus Ornith. anatinus XP_001506028 1287 141359 V575 E M V Q E E P V A P A G P D R
Chicken Gallus gallus Q5F3P8 2008 223067 S968 D Q K R I R P S T S V D D E D
Frog Xenopus laevis Q66J90 1938 216239 S933 D Q K R I R P S H S V D D E D
Zebra Danio Brachydanio rerio Q1LY77 1844 204122 L971 S G K E E S S L S D H E E E P
Tiger Blowfish Takifugu rubipres
Fruit Fly Dros. melanogaster NP_001015221 1641 188364 V883 R S K I K G P V P I Q E S D S
Honey Bee Apis mellifera XP_395451 1406 159180 H694 E D S R Q S D H A D T E L I G
Nematode Worm Caenorhab. elegans Q18221 1507 171664 K795 C F A A L D E K L H L K A I A
Sea Urchin Strong. purpuratus XP_791552 1963 220543 F1122 F P G Q L N P F N S P D M L P
Poplar Tree Populus trichocarpa
Maize Zea mays
Rice Oryza sativa
Thale Cress Arabidopsis thaliana
Baker's Yeast Sacchar. cerevisiae P38827 1080 123894 A368 L Q E N L K K A K E K E A E N
Red Bread Mold Neurospora crassa Q8X0S9 1313 145607 K601 A D I E E E K K Q R A K N L D
Conservation
Percent
Protein Identity: 100 99.5 N.A. 73.2 N.A. 37 N.A. N.A. 27.7 34.5 34.1 36.7 N.A. 25.6 24.6 20.9 23.7
Protein Similarity: 100 99.5 N.A. 74.7 N.A. 49.5 N.A. N.A. 38.7 47.5 48.6 50.7 N.A. 41.3 39.6 35.8 39.2
P-Site Identity: 100 100 N.A. 26.6 N.A. 46.6 N.A. N.A. 33.3 40 33.3 20 N.A. 26.6 20 0 6.6
P-Site Similarity: 100 100 N.A. 40 N.A. 80 N.A. N.A. 40 80 73.3 33.3 N.A. 26.6 26.6 6.6 20
Percent
Protein Identity: N.A. N.A. N.A. N.A. 21.7 22.2
Protein Similarity: N.A. N.A. N.A. N.A. 33.8 36.5
P-Site Identity: N.A. N.A. N.A. N.A. 6.6 6.6
P-Site Similarity: N.A. N.A. N.A. N.A. 40 26.6
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 8 8 15 8 0 0 0 8 15 0 29 0 15 0 8 % A
% Cys: 8 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % C
% Asp: 22 15 0 0 0 8 8 0 0 15 0 29 15 29 29 % D
% Glu: 29 15 8 22 22 15 8 0 0 8 0 43 29 43 22 % E
% Phe: 8 8 0 0 0 0 0 8 0 0 0 0 0 0 0 % F
% Gly: 0 8 8 0 0 8 0 0 0 0 0 8 8 0 8 % G
% His: 0 0 0 0 0 0 0 8 8 8 8 0 0 0 0 % H
% Ile: 0 0 8 8 15 0 0 0 0 8 0 0 0 15 0 % I
% Lys: 0 0 50 0 8 8 15 15 8 0 8 15 0 0 0 % K
% Leu: 8 0 0 0 29 8 0 8 8 0 8 0 8 15 0 % L
% Met: 0 8 0 0 0 0 0 0 0 0 0 0 8 0 0 % M
% Asn: 0 0 0 8 0 8 0 0 8 0 0 0 8 0 8 % N
% Pro: 0 8 0 0 22 0 65 0 8 22 8 0 8 0 15 % P
% Gln: 0 29 0 15 8 0 0 0 8 0 8 0 0 0 0 % Q
% Arg: 8 0 0 43 0 36 0 0 0 8 0 0 0 0 8 % R
% Ser: 8 8 8 0 0 15 8 43 15 36 0 8 8 0 8 % S
% Thr: 0 0 0 0 0 0 0 0 29 0 8 0 0 0 0 % T
% Val: 8 0 8 0 0 0 0 15 0 0 29 0 0 0 0 % V
% Trp: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % W
% Tyr: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _