Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.

Updated: 2017 Aug. 1

| Home | Kinexus | Contact | Credits

Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: SETD1A All Species: 6.36
Human Site: T599 Identified Species: 10.77
UniProt: O15047 Number Species: 13
    Phosphosite Substitution
    Charge Score: 0.15
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens O15047 NP_055527.1 1707 186034 T599 G S P P P A P T P P Q Q P P P
Chimpanzee Pan troglodytes XP_523492 1707 185692 T599 G S P A P A P T P P Q Q P P P
Rhesus Macaque Macaca mulatta
Dog Lupus familis XP_848999 1330 145541 S338 T A A T A S S S S S S S S S T
Cat Felis silvestris
Mouse Mus musculus Q8CFT2 1985 215333 D646 S A P I T S A D C P K P M V V
Rat Rattus norvegicus
Wallaby Macropus eugenll
Platypus Ornith. anatinus XP_001506028 1287 141359 G295 L L E N W N K G E G L G Y E G
Chicken Gallus gallus Q5F3P8 2008 223067 C656 A P I T S A E C A K T I V V N
Frog Xenopus laevis Q66J90 1938 216239 M621 H P S S G E D M E I S D D E V
Zebra Danio Brachydanio rerio Q1LY77 1844 204122 P641 L S L I Q T I P M P P P G F P
Tiger Blowfish Takifugu rubipres
Fruit Fly Dros. melanogaster NP_001015221 1641 188364 G599 S S D E E L I G K K D K S K L
Honey Bee Apis mellifera XP_395451 1406 159180 N414 K V H E N S I N Q F S V D E D
Nematode Worm Caenorhab. elegans Q18221 1507 171664 R515 T R R R R S G R S Q N R S S E
Sea Urchin Strong. purpuratus XP_791552 1963 220543 E677 D Q C H P P G E E P P S T S P
Poplar Tree Populus trichocarpa
Maize Zea mays
Rice Oryza sativa
Thale Cress Arabidopsis thaliana
Baker's Yeast Sacchar. cerevisiae P38827 1080 123894 Y88 N N S Q S G P Y V N K K S D I
Red Bread Mold Neurospora crassa Q8X0S9 1313 145607 D321 T I F A S F G D I A E S S N K
Conservation
Percent
Protein Identity: 100 99.5 N.A. 73.2 N.A. 37 N.A. N.A. 27.7 34.5 34.1 36.7 N.A. 25.6 24.6 20.9 23.7
Protein Similarity: 100 99.5 N.A. 74.7 N.A. 49.5 N.A. N.A. 38.7 47.5 48.6 50.7 N.A. 41.3 39.6 35.8 39.2
P-Site Identity: 100 93.3 N.A. 0 N.A. 13.3 N.A. N.A. 0 6.6 0 20 N.A. 6.6 0 0 20
P-Site Similarity: 100 93.3 N.A. 20 N.A. 33.3 N.A. N.A. 0 6.6 0 20 N.A. 13.3 6.6 13.3 20
Percent
Protein Identity: N.A. N.A. N.A. N.A. 21.7 22.2
Protein Similarity: N.A. N.A. N.A. N.A. 33.8 36.5
P-Site Identity: N.A. N.A. N.A. N.A. 6.6 0
P-Site Similarity: N.A. N.A. N.A. N.A. 26.6 6.6
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 8 15 8 15 8 22 8 0 8 8 0 0 0 0 0 % A
% Cys: 0 0 8 0 0 0 0 8 8 0 0 0 0 0 0 % C
% Asp: 8 0 8 0 0 0 8 15 0 0 8 8 15 8 8 % D
% Glu: 0 0 8 15 8 8 8 8 22 0 8 0 0 22 8 % E
% Phe: 0 0 8 0 0 8 0 0 0 8 0 0 0 8 0 % F
% Gly: 15 0 0 0 8 8 22 15 0 8 0 8 8 0 8 % G
% His: 8 0 8 8 0 0 0 0 0 0 0 0 0 0 0 % H
% Ile: 0 8 8 15 0 0 22 0 8 8 0 8 0 0 8 % I
% Lys: 8 0 0 0 0 0 8 0 8 15 15 15 0 8 8 % K
% Leu: 15 8 8 0 0 8 0 0 0 0 8 0 0 0 8 % L
% Met: 0 0 0 0 0 0 0 8 8 0 0 0 8 0 0 % M
% Asn: 8 8 0 8 8 8 0 8 0 8 8 0 0 8 8 % N
% Pro: 0 15 22 8 22 8 22 8 15 36 15 15 15 15 29 % P
% Gln: 0 8 0 8 8 0 0 0 8 8 15 15 0 0 0 % Q
% Arg: 0 8 8 8 8 0 0 8 0 0 0 8 0 0 0 % R
% Ser: 15 29 15 8 22 29 8 8 15 8 22 22 36 22 0 % S
% Thr: 22 0 0 15 8 8 0 15 0 0 8 0 8 0 8 % T
% Val: 0 8 0 0 0 0 0 0 8 0 0 8 8 15 15 % V
% Trp: 0 0 0 0 8 0 0 0 0 0 0 0 0 0 0 % W
% Tyr: 0 0 0 0 0 0 0 8 0 0 0 0 8 0 0 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _