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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: KDM6B All Species: 14.24
Human Site: S559 Identified Species: 31.33
UniProt: O15054 Number Species: 10
    Phosphosite Substitution
    Charge Score: 0.1
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens O15054 NP_001073893 1679 180411 S559 N S N S G S H S S S P A G P V
Chimpanzee Pan troglodytes
Rhesus Macaque Macaca mulatta XP_001110616 1677 180308 S558 N S N N G S H S S S P A G P V
Dog Lupus familis XP_546599 1653 177377 S566 S S N H G S H S S S P T G P V
Cat Felis silvestris
Mouse Mus musculus Q5NCY0 1641 176337 S564 S S S S N S H S S S P T G P V
Rat Rattus norvegicus NP_001102299 1361 146305 A331 P L P P L T L A L P P A P P S
Wallaby Macropus eugenll
Platypus Ornith. anatinus XP_001512545 1373 151321 D343 E S C N Q P Q D A I K C Y L N
Chicken Gallus gallus XP_416762 1384 152840 A354 S C N Q P Q D A I K C Y L N A
Frog Xenopus laevis NP_001086774 1455 160368 W425 L P S I E E A W S L P I P A E
Zebra Danio Brachydanio rerio XP_684619 1964 216217 S573 T P V S S T P S T L N S G L Q
Tiger Blowfish Takifugu rubipres
Fruit Fly Dros. melanogaster NP_723550 939 106399
Honey Bee Apis mellifera
Nematode Worm Caenorhab. elegans
Sea Urchin Strong. purpuratus XP_001203582 1412 156309 Q382 S F Y L T A Q Q I Q L M H Q L
Poplar Tree Populus trichocarpa
Maize Zea mays
Rice Oryza sativa
Thale Cress Arabidopsis thaliana
Baker's Yeast Sacchar. cerevisiae
Red Bread Mold Neurospora crassa
Conservation
Percent
Protein Identity: 100 N.A. 98 91.7 N.A. 90.1 74.6 N.A. 31.8 31.6 31 39.5 N.A. 27.6 N.A. N.A. 29.6
Protein Similarity: 100 N.A. 98.4 93 N.A. 92.2 76.2 N.A. 44.3 44.7 45 51 N.A. 39.4 N.A. N.A. 43.7
P-Site Identity: 100 N.A. 93.3 80 N.A. 73.3 20 N.A. 6.6 6.6 13.3 20 N.A. 0 N.A. N.A. 0
P-Site Similarity: 100 N.A. 100 86.6 N.A. 86.6 33.3 N.A. 20 20 20 40 N.A. 0 N.A. N.A. 20
Percent
Protein Identity: N.A. N.A. N.A. N.A. N.A. N.A.
Protein Similarity: N.A. N.A. N.A. N.A. N.A. N.A.
P-Site Identity: N.A. N.A. N.A. N.A. N.A. N.A.
P-Site Similarity: N.A. N.A. N.A. N.A. N.A. N.A.
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 0 0 0 0 0 10 10 19 10 0 0 28 0 10 10 % A
% Cys: 0 10 10 0 0 0 0 0 0 0 10 10 0 0 0 % C
% Asp: 0 0 0 0 0 0 10 10 0 0 0 0 0 0 0 % D
% Glu: 10 0 0 0 10 10 0 0 0 0 0 0 0 0 10 % E
% Phe: 0 10 0 0 0 0 0 0 0 0 0 0 0 0 0 % F
% Gly: 0 0 0 0 28 0 0 0 0 0 0 0 46 0 0 % G
% His: 0 0 0 10 0 0 37 0 0 0 0 0 10 0 0 % H
% Ile: 0 0 0 10 0 0 0 0 19 10 0 10 0 0 0 % I
% Lys: 0 0 0 0 0 0 0 0 0 10 10 0 0 0 0 % K
% Leu: 10 10 0 10 10 0 10 0 10 19 10 0 10 19 10 % L
% Met: 0 0 0 0 0 0 0 0 0 0 0 10 0 0 0 % M
% Asn: 19 0 37 19 10 0 0 0 0 0 10 0 0 10 10 % N
% Pro: 10 19 10 10 10 10 10 0 0 10 55 0 19 46 0 % P
% Gln: 0 0 0 10 10 10 19 10 0 10 0 0 0 10 10 % Q
% Arg: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % R
% Ser: 37 46 19 28 10 37 0 46 46 37 0 10 0 0 10 % S
% Thr: 10 0 0 0 10 19 0 0 10 0 0 19 0 0 0 % T
% Val: 0 0 10 0 0 0 0 0 0 0 0 0 0 0 37 % V
% Trp: 0 0 0 0 0 0 0 10 0 0 0 0 0 0 0 % W
% Tyr: 0 0 10 0 0 0 0 0 0 0 0 10 10 0 0 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _