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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: PFAS All Species: 9.09
Human Site: S1062 Identified Species: 16.67
UniProt: O15067 Number Species: 12
    Phosphosite Substitution
    Charge Score: -0.33
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens O15067 NP_036525 1338 144724 S1062 P R E P G G P S P R V A I L R
Chimpanzee Pan troglodytes XP_511854 1397 150781 S1121 P R E P G G P S P R V A I L R
Rhesus Macaque Macaca mulatta XP_001112405 1335 144369 S1062 P R E P G G P S P R V A I L R
Dog Lupus familis XP_850167 1368 147436 V1062 P R E P G G P V P R V A I L R
Cat Felis silvestris
Mouse Mus musculus Q5SUR0 1337 144611 V1061 P C K P G G P V P R V A I L R
Rat Rattus norvegicus NP_001099261 1271 136879 I995 P C K P G G P I P R V A I L R
Wallaby Macropus eugenll
Platypus Ornith. anatinus
Chicken Gallus gallus
Frog Xenopus laevis
Zebra Danio Brachydanio rerio NP_001038667 1314 142462 K1051 I K E L A T G K A R V A V V R
Tiger Blowfish Takifugu rubipres
Fruit Fly Dros. melanogaster P35421 1354 148067 P1084 T L K R S S A P V R V A V L R
Honey Bee Apis mellifera XP_625036 1243 138433 K998 I H K N L S S K I A V V V L R
Nematode Worm Caenorhab. elegans Q19311 1343 148611 A1070 N E Q Y F S T A P R V A I I R
Sea Urchin Strong. purpuratus XP_781955 1205 129101 R928 V Q E T S E C R P K V A V I R
Poplar Tree Populus trichocarpa XP_002315209 1377 150616 K1107 K Y M I A T S K P K V A V I R
Maize Zea mays
Rice Oryza sativa
Thale Cress Arabidopsis thaliana Q9M8D3 1387 151761 I1119 N Y M S Q G M I P K V A V I R
Baker's Yeast Sacchar. cerevisiae
Red Bread Mold Neurospora crassa
Conservation
Percent
Protein Identity: 100 94.9 97.1 87.5 N.A. 88.5 84 N.A. N.A. N.A. N.A. 63.2 N.A. 50.5 50.1 47.5 52.4
Protein Similarity: 100 95.2 98 91.6 N.A. 92.8 88.6 N.A. N.A. N.A. N.A. 75.1 N.A. 66 66.2 64.1 65.4
P-Site Identity: 100 100 100 93.3 N.A. 80 80 N.A. N.A. N.A. N.A. 33.3 N.A. 33.3 20 40 33.3
P-Site Similarity: 100 100 100 93.3 N.A. 86.6 86.6 N.A. N.A. N.A. N.A. 53.3 N.A. 46.6 33.3 60 60
Percent
Protein Identity: 50.3 N.A. N.A. 50.4 N.A. N.A.
Protein Similarity: 65.2 N.A. N.A. 65.3 N.A. N.A.
P-Site Identity: 26.6 N.A. N.A. 33.3 N.A. N.A.
P-Site Similarity: 46.6 N.A. N.A. 53.3 N.A. N.A.
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 0 0 0 0 16 0 8 8 8 8 0 93 0 0 0 % A
% Cys: 0 16 0 0 0 0 8 0 0 0 0 0 0 0 0 % C
% Asp: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % D
% Glu: 0 8 47 0 0 8 0 0 0 0 0 0 0 0 0 % E
% Phe: 0 0 0 0 8 0 0 0 0 0 0 0 0 0 0 % F
% Gly: 0 0 0 0 47 54 8 0 0 0 0 0 0 0 0 % G
% His: 0 8 0 0 0 0 0 0 0 0 0 0 0 0 0 % H
% Ile: 16 0 0 8 0 0 0 16 8 0 0 0 54 31 0 % I
% Lys: 8 8 31 0 0 0 0 24 0 24 0 0 0 0 0 % K
% Leu: 0 8 0 8 8 0 0 0 0 0 0 0 0 62 0 % L
% Met: 0 0 16 0 0 0 8 0 0 0 0 0 0 0 0 % M
% Asn: 16 0 0 8 0 0 0 0 0 0 0 0 0 0 0 % N
% Pro: 47 0 0 47 0 0 47 8 77 0 0 0 0 0 0 % P
% Gln: 0 8 8 0 8 0 0 0 0 0 0 0 0 0 0 % Q
% Arg: 0 31 0 8 0 0 0 8 0 70 0 0 0 0 100 % R
% Ser: 0 0 0 8 16 24 16 24 0 0 0 0 0 0 0 % S
% Thr: 8 0 0 8 0 16 8 0 0 0 0 0 0 0 0 % T
% Val: 8 0 0 0 0 0 0 16 8 0 100 8 47 8 0 % V
% Trp: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % W
% Tyr: 0 16 0 8 0 0 0 0 0 0 0 0 0 0 0 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _