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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: PFAS All Species: 47.27
Human Site: S676 Identified Species: 86.67
UniProt: O15067 Number Species: 12
    Phosphosite Substitution
    Charge Score: 0
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens O15067 NP_036525 1338 144724 S676 L R L P A V A S K R Y L T N K
Chimpanzee Pan troglodytes XP_511854 1397 150781 S735 L R L P A V A S K R Y L T N K
Rhesus Macaque Macaca mulatta XP_001112405 1335 144369 S676 L R L P A V A S K R Y L T N K
Dog Lupus familis XP_850167 1368 147436 S676 L R L P A V A S K R Y L T N K
Cat Felis silvestris
Mouse Mus musculus Q5SUR0 1337 144611 S675 L R L P A V A S K R Y L T N K
Rat Rattus norvegicus NP_001099261 1271 136879 S604 L R L P A V A S K R Y L T N K
Wallaby Macropus eugenll
Platypus Ornith. anatinus
Chicken Gallus gallus
Frog Xenopus laevis
Zebra Danio Brachydanio rerio NP_001038667 1314 142462 S665 L R L P A V A S K R Y L T N K
Tiger Blowfish Takifugu rubipres
Fruit Fly Dros. melanogaster P35421 1354 148067 S684 L S L V A V G S K R F L T N K
Honey Bee Apis mellifera XP_625036 1243 138433 S609 L R L P S V G S K R Y L T N K
Nematode Worm Caenorhab. elegans Q19311 1343 148611 S651 L M L P S V A S K R Y L T C K
Sea Urchin Strong. purpuratus XP_781955 1205 129101 G591 I G S A T A I G E Q P I K G L
Poplar Tree Populus trichocarpa XP_002315209 1377 150616 S725 L R L P S V C S K R F L T T K
Maize Zea mays
Rice Oryza sativa
Thale Cress Arabidopsis thaliana Q9M8D3 1387 151761 S736 L R L P S V S S K R F L T T K
Baker's Yeast Sacchar. cerevisiae
Red Bread Mold Neurospora crassa
Conservation
Percent
Protein Identity: 100 94.9 97.1 87.5 N.A. 88.5 84 N.A. N.A. N.A. N.A. 63.2 N.A. 50.5 50.1 47.5 52.4
Protein Similarity: 100 95.2 98 91.6 N.A. 92.8 88.6 N.A. N.A. N.A. N.A. 75.1 N.A. 66 66.2 64.1 65.4
P-Site Identity: 100 100 100 100 N.A. 100 100 N.A. N.A. N.A. N.A. 100 N.A. 73.3 86.6 80 0
P-Site Similarity: 100 100 100 100 N.A. 100 100 N.A. N.A. N.A. N.A. 100 N.A. 80 93.3 86.6 26.6
Percent
Protein Identity: 50.3 N.A. N.A. 50.4 N.A. N.A.
Protein Similarity: 65.2 N.A. N.A. 65.3 N.A. N.A.
P-Site Identity: 73.3 N.A. N.A. 73.3 N.A. N.A.
P-Site Similarity: 86.6 N.A. N.A. 93.3 N.A. N.A.
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 0 0 0 8 62 8 62 0 0 0 0 0 0 0 0 % A
% Cys: 0 0 0 0 0 0 8 0 0 0 0 0 0 8 0 % C
% Asp: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % D
% Glu: 0 0 0 0 0 0 0 0 8 0 0 0 0 0 0 % E
% Phe: 0 0 0 0 0 0 0 0 0 0 24 0 0 0 0 % F
% Gly: 0 8 0 0 0 0 16 8 0 0 0 0 0 8 0 % G
% His: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % H
% Ile: 8 0 0 0 0 0 8 0 0 0 0 8 0 0 0 % I
% Lys: 0 0 0 0 0 0 0 0 93 0 0 0 8 0 93 % K
% Leu: 93 0 93 0 0 0 0 0 0 0 0 93 0 0 8 % L
% Met: 0 8 0 0 0 0 0 0 0 0 0 0 0 0 0 % M
% Asn: 0 0 0 0 0 0 0 0 0 0 0 0 0 70 0 % N
% Pro: 0 0 0 85 0 0 0 0 0 0 8 0 0 0 0 % P
% Gln: 0 0 0 0 0 0 0 0 0 8 0 0 0 0 0 % Q
% Arg: 0 77 0 0 0 0 0 0 0 93 0 0 0 0 0 % R
% Ser: 0 8 8 0 31 0 8 93 0 0 0 0 0 0 0 % S
% Thr: 0 0 0 0 8 0 0 0 0 0 0 0 93 16 0 % T
% Val: 0 0 0 8 0 93 0 0 0 0 0 0 0 0 0 % V
% Trp: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % W
% Tyr: 0 0 0 0 0 0 0 0 0 0 70 0 0 0 0 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _