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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: PFAS All Species: 17.27
Human Site: T1316 Identified Species: 31.67
UniProt: O15067 Number Species: 12
    Phosphosite Substitution
    Charge Score: 0
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens O15067 NP_036525 1338 144724 T1316 W R P P P F D T L T T S P W L
Chimpanzee Pan troglodytes XP_511854 1397 150781 T1375 W R P P P F D T L T T S P W L
Rhesus Macaque Macaca mulatta XP_001112405 1335 144369 T1313 W R P P P F D T L T T S P W L
Dog Lupus familis XP_850167 1368 147436 T1346 W R P P L F D T V T T S P W L
Cat Felis silvestris
Mouse Mus musculus Q5SUR0 1337 144611 V1315 W R P S P F D V L P T S P W L
Rat Rattus norvegicus NP_001099261 1271 136879 G1249 W R P S P F D G L S T S P W L
Wallaby Macropus eugenll
Platypus Ornith. anatinus
Chicken Gallus gallus
Frog Xenopus laevis
Zebra Danio Brachydanio rerio NP_001038667 1314 142462 A1278 M M P H P E R A V L S W Q W A
Tiger Blowfish Takifugu rubipres
Fruit Fly Dros. melanogaster P35421 1354 148067 T1332 S S F E V S P T Q S E S P W Q
Honey Bee Apis mellifera XP_625036 1243 138433 K1222 P W K P Y D W K Y S I S P W Q
Nematode Worm Caenorhab. elegans Q19311 1343 148611 T1306 H A D R S F L T W Q W A E S S
Sea Urchin Strong. purpuratus XP_781955 1205 129101 D1183 M P A E W R R D L K A S P W L
Poplar Tree Populus trichocarpa XP_002315209 1377 150616 T1353 W Q F P W Y P T Q W N V D K K
Maize Zea mays
Rice Oryza sativa
Thale Cress Arabidopsis thaliana Q9M8D3 1387 151761 W1358 F L M W Q F P W Y P T S W D V
Baker's Yeast Sacchar. cerevisiae
Red Bread Mold Neurospora crassa
Conservation
Percent
Protein Identity: 100 94.9 97.1 87.5 N.A. 88.5 84 N.A. N.A. N.A. N.A. 63.2 N.A. 50.5 50.1 47.5 52.4
Protein Similarity: 100 95.2 98 91.6 N.A. 92.8 88.6 N.A. N.A. N.A. N.A. 75.1 N.A. 66 66.2 64.1 65.4
P-Site Identity: 100 100 100 86.6 N.A. 80 80 N.A. N.A. N.A. N.A. 20 N.A. 26.6 26.6 13.3 33.3
P-Site Similarity: 100 100 100 93.3 N.A. 80 86.6 N.A. N.A. N.A. N.A. 33.3 N.A. 33.3 33.3 20 33.3
Percent
Protein Identity: 50.3 N.A. N.A. 50.4 N.A. N.A.
Protein Similarity: 65.2 N.A. N.A. 65.3 N.A. N.A.
P-Site Identity: 20 N.A. N.A. 20 N.A. N.A.
P-Site Similarity: 33.3 N.A. N.A. 33.3 N.A. N.A.
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 0 8 8 0 0 0 0 8 0 0 8 8 0 0 8 % A
% Cys: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % C
% Asp: 0 0 8 0 0 8 47 8 0 0 0 0 8 8 0 % D
% Glu: 0 0 0 16 0 8 0 0 0 0 8 0 8 0 0 % E
% Phe: 8 0 16 0 0 62 0 0 0 0 0 0 0 0 0 % F
% Gly: 0 0 0 0 0 0 0 8 0 0 0 0 0 0 0 % G
% His: 8 0 0 8 0 0 0 0 0 0 0 0 0 0 0 % H
% Ile: 0 0 0 0 0 0 0 0 0 0 8 0 0 0 0 % I
% Lys: 0 0 8 0 0 0 0 8 0 8 0 0 0 8 8 % K
% Leu: 0 8 0 0 8 0 8 0 47 8 0 0 0 0 54 % L
% Met: 16 8 8 0 0 0 0 0 0 0 0 0 0 0 0 % M
% Asn: 0 0 0 0 0 0 0 0 0 0 8 0 0 0 0 % N
% Pro: 8 8 54 47 47 0 24 0 0 16 0 0 70 0 0 % P
% Gln: 0 8 0 0 8 0 0 0 16 8 0 0 8 0 16 % Q
% Arg: 0 47 0 8 0 8 16 0 0 0 0 0 0 0 0 % R
% Ser: 8 8 0 16 8 8 0 0 0 24 8 77 0 8 8 % S
% Thr: 0 0 0 0 0 0 0 54 0 31 54 0 0 0 0 % T
% Val: 0 0 0 0 8 0 0 8 16 0 0 8 0 0 8 % V
% Trp: 54 8 0 8 16 0 8 8 8 8 8 8 8 77 0 % W
% Tyr: 0 0 0 0 8 8 0 0 16 0 0 0 0 0 0 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _