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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: PFAS All Species: 11.21
Human Site: T619 Identified Species: 20.56
UniProt: O15067 Number Species: 12
    Phosphosite Substitution
    Charge Score: -0.08
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens O15067 NP_036525 1338 144724 T619 G Q G D A P P T P L P T P V D
Chimpanzee Pan troglodytes XP_511854 1397 150781 T678 G Q G D A P P T P P P T P V D
Rhesus Macaque Macaca mulatta XP_001112405 1335 144369 T619 G Q G D A P P T P P P T P V D
Dog Lupus familis XP_850167 1368 147436 S619 G H E D A S L S S P P T P V D
Cat Felis silvestris
Mouse Mus musculus Q5SUR0 1337 144611 L618 T G Q G D A P L T P P T P V D
Rat Rattus norvegicus NP_001099261 1271 136879 K567 V L G K M P Q K E F F L Q R K
Wallaby Macropus eugenll
Platypus Ornith. anatinus
Chicken Gallus gallus
Frog Xenopus laevis
Zebra Danio Brachydanio rerio NP_001038667 1314 142462 E608 R K Q N D V L E G A R N P V D
Tiger Blowfish Takifugu rubipres
Fruit Fly Dros. melanogaster P35421 1354 148067 R627 Q A L N A S N R S E V S P F D
Honey Bee Apis mellifera XP_625036 1243 138433 F574 G K M P Q K T F N L L R Q I T
Nematode Worm Caenorhab. elegans Q19311 1343 148611 F616 G E R E K K V F K L K S A P R
Sea Urchin Strong. purpuratus XP_781955 1205 129101 V557 D R S V T G L V A Q Q Q C V G
Poplar Tree Populus trichocarpa XP_002315209 1377 150616 P668 K C R A N G L P P P P P A V D
Maize Zea mays
Rice Oryza sativa
Thale Cress Arabidopsis thaliana Q9M8D3 1387 151761 P679 K C S K E G L P P P P P A V D
Baker's Yeast Sacchar. cerevisiae
Red Bread Mold Neurospora crassa
Conservation
Percent
Protein Identity: 100 94.9 97.1 87.5 N.A. 88.5 84 N.A. N.A. N.A. N.A. 63.2 N.A. 50.5 50.1 47.5 52.4
Protein Similarity: 100 95.2 98 91.6 N.A. 92.8 88.6 N.A. N.A. N.A. N.A. 75.1 N.A. 66 66.2 64.1 65.4
P-Site Identity: 100 93.3 93.3 53.3 N.A. 40 13.3 N.A. N.A. N.A. N.A. 20 N.A. 20 13.3 13.3 6.6
P-Site Similarity: 100 93.3 93.3 60 N.A. 40 13.3 N.A. N.A. N.A. N.A. 33.3 N.A. 33.3 26.6 33.3 13.3
Percent
Protein Identity: 50.3 N.A. N.A. 50.4 N.A. N.A.
Protein Similarity: 65.2 N.A. N.A. 65.3 N.A. N.A.
P-Site Identity: 26.6 N.A. N.A. 26.6 N.A. N.A.
P-Site Similarity: 26.6 N.A. N.A. 26.6 N.A. N.A.
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 0 8 0 8 39 8 0 0 8 8 0 0 24 0 0 % A
% Cys: 0 16 0 0 0 0 0 0 0 0 0 0 8 0 0 % C
% Asp: 8 0 0 31 16 0 0 0 0 0 0 0 0 0 70 % D
% Glu: 0 8 8 8 8 0 0 8 8 8 0 0 0 0 0 % E
% Phe: 0 0 0 0 0 0 0 16 0 8 8 0 0 8 0 % F
% Gly: 47 8 31 8 0 24 0 0 8 0 0 0 0 0 8 % G
% His: 0 8 0 0 0 0 0 0 0 0 0 0 0 0 0 % H
% Ile: 0 0 0 0 0 0 0 0 0 0 0 0 0 8 0 % I
% Lys: 16 16 0 16 8 16 0 8 8 0 8 0 0 0 8 % K
% Leu: 0 8 8 0 0 0 39 8 0 24 8 8 0 0 0 % L
% Met: 0 0 8 0 8 0 0 0 0 0 0 0 0 0 0 % M
% Asn: 0 0 0 16 8 0 8 0 8 0 0 8 0 0 0 % N
% Pro: 0 0 0 8 0 31 31 16 39 47 54 16 54 8 0 % P
% Gln: 8 24 16 0 8 0 8 0 0 8 8 8 16 0 0 % Q
% Arg: 8 8 16 0 0 0 0 8 0 0 8 8 0 8 8 % R
% Ser: 0 0 16 0 0 16 0 8 16 0 0 16 0 0 0 % S
% Thr: 8 0 0 0 8 0 8 24 8 0 0 39 0 0 8 % T
% Val: 8 0 0 8 0 8 8 8 0 0 8 0 0 70 0 % V
% Trp: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % W
% Tyr: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _