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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: SMAD7 All Species: 23.94
Human Site: S206 Identified Species: 40.51
UniProt: O15105 Number Species: 13
    Phosphosite Substitution
    Charge Score: 0.08
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens O15105 NP_005895.1 426 46426 S206 S R L C E L E S P P P P Y S R
Chimpanzee Pan troglodytes XP_512124 426 46437 S206 S R L C E L E S P P P P Y S R
Rhesus Macaque Macaca mulatta XP_001087560 426 46226 S206 S R L C E L E S P P P P Y S R
Dog Lupus familis XP_850493 430 46498 E210 L S R L C E L E S P P P P Y S
Cat Felis silvestris
Mouse Mus musculus O35253 426 46423 S206 S R L C E L E S P P P P Y S R
Rat Rattus norvegicus O88406 426 46439 S206 S R L C E L E S P P P P Y S R
Wallaby Macropus eugenll
Platypus Ornith. anatinus XP_001509923 178 20616
Chicken Gallus gallus Q9W734 431 47806 P210 L C G P E S P P P P Y S R L S
Frog Xenopus laevis NP_001081017 382 42694 S162 S R L C E L E S P P P P Y T R
Zebra Danio Brachydanio rerio Q9I9P9 468 52435 P222 N N Y I P E T P P P G Y I S E
Tiger Blowfish Takifugu rubipres
Fruit Fly Dros. melanogaster P42003 455 50486 N209 S P S S V N S N P N S P Y D S
Honey Bee Apis mellifera XP_396816 251 28007 S32 K R L P V C H S A K D P V Y I
Nematode Worm Caenorhab. elegans P45897 570 63351 I333 P I I S D I P I D L N Q I Y V
Sea Urchin Strong. purpuratus XP_798238 371 42051 I151 P P P P Y S R I A F E R S K T
Poplar Tree Populus trichocarpa
Maize Zea mays
Rice Oryza sativa
Thale Cress Arabidopsis thaliana
Baker's Yeast Sacchar. cerevisiae
Red Bread Mold Neurospora crassa
Conservation
Percent
Protein Identity: 100 99.7 94.8 95.8 N.A. 98.1 97.8 N.A. 40.8 51.5 77.2 22.6 N.A. 20.2 30.7 20.5 43.4
Protein Similarity: 100 99.7 96.7 96.7 N.A. 98.5 98.5 N.A. 41.3 64.5 81.9 37.3 N.A. 36 39.6 35 57.2
P-Site Identity: 100 100 100 20 N.A. 100 100 N.A. 0 20 93.3 20 N.A. 26.6 26.6 0 0
P-Site Similarity: 100 100 100 20 N.A. 100 100 N.A. 0 20 100 26.6 N.A. 33.3 26.6 20 0
Percent
Protein Identity: N.A. N.A. N.A. N.A. N.A. N.A.
Protein Similarity: N.A. N.A. N.A. N.A. N.A. N.A.
P-Site Identity: N.A. N.A. N.A. N.A. N.A. N.A.
P-Site Similarity: N.A. N.A. N.A. N.A. N.A. N.A.
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 0 0 0 0 0 0 0 0 15 0 0 0 0 0 0 % A
% Cys: 0 8 0 43 8 8 0 0 0 0 0 0 0 0 0 % C
% Asp: 0 0 0 0 8 0 0 0 8 0 8 0 0 8 0 % D
% Glu: 0 0 0 0 50 15 43 8 0 0 8 0 0 0 8 % E
% Phe: 0 0 0 0 0 0 0 0 0 8 0 0 0 0 0 % F
% Gly: 0 0 8 0 0 0 0 0 0 0 8 0 0 0 0 % G
% His: 0 0 0 0 0 0 8 0 0 0 0 0 0 0 0 % H
% Ile: 0 8 8 8 0 8 0 15 0 0 0 0 15 0 8 % I
% Lys: 8 0 0 0 0 0 0 0 0 8 0 0 0 8 0 % K
% Leu: 15 0 50 8 0 43 8 0 0 8 0 0 0 8 0 % L
% Met: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % M
% Asn: 8 8 0 0 0 8 0 8 0 8 8 0 0 0 0 % N
% Pro: 15 15 8 22 8 0 15 15 65 65 50 65 8 0 0 % P
% Gln: 0 0 0 0 0 0 0 0 0 0 0 8 0 0 0 % Q
% Arg: 0 50 8 0 0 0 8 0 0 0 0 8 8 0 43 % R
% Ser: 50 8 8 15 0 15 8 50 8 0 8 8 8 43 22 % S
% Thr: 0 0 0 0 0 0 8 0 0 0 0 0 0 8 8 % T
% Val: 0 0 0 0 15 0 0 0 0 0 0 0 8 0 8 % V
% Trp: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % W
% Tyr: 0 0 8 0 8 0 0 0 0 0 8 8 50 22 0 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _