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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: SMAD7 All Species: 27.88
Human Site: S231 Identified Species: 47.18
UniProt: O15105 Number Species: 13
    Phosphosite Substitution
    Charge Score: 0
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens O15105 NP_005895.1 426 46426 S231 D C P D A V P S S A E T G G T
Chimpanzee Pan troglodytes XP_512124 426 46437 S231 D C P D A V P S S A E T G G T
Rhesus Macaque Macaca mulatta XP_001087560 426 46226 S231 D C P D A V P S S A E T G G T
Dog Lupus familis XP_850493 430 46498 S235 D C P D A V P S S A E T G G T
Cat Felis silvestris
Mouse Mus musculus O35253 426 46423 S231 G C P D A V P S S A E T G G T
Rat Rattus norvegicus O88406 426 46439 S231 D C P D A V P S S D E T G G T
Wallaby Macropus eugenll
Platypus Ornith. anatinus XP_001509923 178 20616
Chicken Gallus gallus Q9W734 431 47806 T235 S D S T L S Y T E T E A T N S
Frog Xenopus laevis NP_001081017 382 42694 S187 D S P D S V P S S T E T G G T
Zebra Danio Brachydanio rerio Q9I9P9 468 52435 P247 Q S M D T G S P A E L S P S T
Tiger Blowfish Takifugu rubipres
Fruit Fly Dros. melanogaster P42003 455 50486 N234 P S E D G N S N N P N D G G Q
Honey Bee Apis mellifera XP_396816 251 28007 P57 C K P E S P P P P Y C L I A D
Nematode Worm Caenorhab. elegans P45897 570 63351 L358 C S I I Y Y E L D T P I G E T
Sea Urchin Strong. purpuratus XP_798238 371 42051 S176 S P V E F G Q S T E T G N T P
Poplar Tree Populus trichocarpa
Maize Zea mays
Rice Oryza sativa
Thale Cress Arabidopsis thaliana
Baker's Yeast Sacchar. cerevisiae
Red Bread Mold Neurospora crassa
Conservation
Percent
Protein Identity: 100 99.7 94.8 95.8 N.A. 98.1 97.8 N.A. 40.8 51.5 77.2 22.6 N.A. 20.2 30.7 20.5 43.4
Protein Similarity: 100 99.7 96.7 96.7 N.A. 98.5 98.5 N.A. 41.3 64.5 81.9 37.3 N.A. 36 39.6 35 57.2
P-Site Identity: 100 100 100 100 N.A. 93.3 93.3 N.A. 0 6.6 80 13.3 N.A. 20 13.3 13.3 6.6
P-Site Similarity: 100 100 100 100 N.A. 93.3 93.3 N.A. 0 20 86.6 26.6 N.A. 33.3 26.6 13.3 20
Percent
Protein Identity: N.A. N.A. N.A. N.A. N.A. N.A.
Protein Similarity: N.A. N.A. N.A. N.A. N.A. N.A.
P-Site Identity: N.A. N.A. N.A. N.A. N.A. N.A.
P-Site Similarity: N.A. N.A. N.A. N.A. N.A. N.A.
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 0 0 0 0 43 0 0 0 8 36 0 8 0 8 0 % A
% Cys: 15 43 0 0 0 0 0 0 0 0 8 0 0 0 0 % C
% Asp: 43 8 0 65 0 0 0 0 8 8 0 8 0 0 8 % D
% Glu: 0 0 8 15 0 0 8 0 8 15 58 0 0 8 0 % E
% Phe: 0 0 0 0 8 0 0 0 0 0 0 0 0 0 0 % F
% Gly: 8 0 0 0 8 15 0 0 0 0 0 8 65 58 0 % G
% His: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % H
% Ile: 0 0 8 8 0 0 0 0 0 0 0 8 8 0 0 % I
% Lys: 0 8 0 0 0 0 0 0 0 0 0 0 0 0 0 % K
% Leu: 0 0 0 0 8 0 0 8 0 0 8 8 0 0 0 % L
% Met: 0 0 8 0 0 0 0 0 0 0 0 0 0 0 0 % M
% Asn: 0 0 0 0 0 8 0 8 8 0 8 0 8 8 0 % N
% Pro: 8 8 58 0 0 8 58 15 8 8 8 0 8 0 8 % P
% Gln: 8 0 0 0 0 0 8 0 0 0 0 0 0 0 8 % Q
% Arg: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % R
% Ser: 15 29 8 0 15 8 15 58 50 0 0 8 0 8 8 % S
% Thr: 0 0 0 8 8 0 0 8 8 22 8 50 8 8 65 % T
% Val: 0 0 8 0 0 50 0 0 0 0 0 0 0 0 0 % V
% Trp: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % W
% Tyr: 0 0 0 0 8 8 8 0 0 8 0 0 0 0 0 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _