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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
SMAD7
All Species:
8.79
Human Site:
S45
Identified Species:
14.87
UniProt:
O15105
Number Species:
13
Phosphosite Substitution
Charge Score:
0.15
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
O15105
NP_005895.1
426
46426
S45
R
G
E
G
A
T
D
S
R
A
H
G
A
G
G
Chimpanzee
Pan troglodytes
XP_512124
426
46437
S45
R
G
E
G
A
T
D
S
R
A
H
G
A
G
S
Rhesus Macaque
Macaca mulatta
XP_001087560
426
46226
S45
R
G
E
G
A
T
D
S
R
A
H
G
A
G
G
Dog
Lupus familis
XP_850493
430
46498
G43
R
G
E
G
A
T
D
G
R
A
H
G
A
G
G
Cat
Felis silvestris
Mouse
Mus musculus
O35253
426
46423
G45
R
G
E
G
A
T
D
G
R
A
Y
G
A
G
G
Rat
Rattus norvegicus
O88406
426
46439
G45
R
G
E
G
A
T
D
G
R
A
Y
G
A
G
G
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001509923
178
20616
Chicken
Gallus gallus
Q9W734
431
47806
A47
T
A
E
G
Q
R
M
A
Q
P
R
R
A
Q
E
Frog
Xenopus laevis
NP_001081017
382
42694
A34
G
G
E
R
A
H
G
A
G
G
C
C
L
G
K
Zebra Danio
Brachydanio rerio
Q9I9P9
468
52435
N35
A
G
G
G
G
E
Q
N
G
Q
E
E
K
W
C
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
P42003
455
50486
E66
K
G
A
I
E
E
L
E
R
A
L
S
C
P
G
Honey Bee
Apis mellifera
XP_396816
251
28007
Nematode Worm
Caenorhab. elegans
P45897
570
63351
N100
P
S
Q
P
S
S
Y
N
N
N
N
I
S
C
V
Sea Urchin
Strong. purpuratus
XP_798238
371
42051
E33
S
G
S
S
A
D
R
E
S
E
A
E
T
D
L
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Baker's Yeast
Sacchar. cerevisiae
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
99.7
94.8
95.8
N.A.
98.1
97.8
N.A.
40.8
51.5
77.2
22.6
N.A.
20.2
30.7
20.5
43.4
Protein Similarity:
100
99.7
96.7
96.7
N.A.
98.5
98.5
N.A.
41.3
64.5
81.9
37.3
N.A.
36
39.6
35
57.2
P-Site Identity:
100
93.3
100
93.3
N.A.
86.6
86.6
N.A.
0
20
26.6
13.3
N.A.
26.6
0
0
13.3
P-Site Similarity:
100
93.3
100
93.3
N.A.
93.3
93.3
N.A.
0
33.3
33.3
20
N.A.
33.3
0
40
13.3
Percent
Protein Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
8
8
8
0
58
0
0
15
0
50
8
0
50
0
0
% A
% Cys:
0
0
0
0
0
0
0
0
0
0
8
8
8
8
8
% C
% Asp:
0
0
0
0
0
8
43
0
0
0
0
0
0
8
0
% D
% Glu:
0
0
58
0
8
15
0
15
0
8
8
15
0
0
8
% E
% Phe:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% F
% Gly:
8
72
8
58
8
0
8
22
15
8
0
43
0
50
43
% G
% His:
0
0
0
0
0
8
0
0
0
0
29
0
0
0
0
% H
% Ile:
0
0
0
8
0
0
0
0
0
0
0
8
0
0
0
% I
% Lys:
8
0
0
0
0
0
0
0
0
0
0
0
8
0
8
% K
% Leu:
0
0
0
0
0
0
8
0
0
0
8
0
8
0
8
% L
% Met:
0
0
0
0
0
0
8
0
0
0
0
0
0
0
0
% M
% Asn:
0
0
0
0
0
0
0
15
8
8
8
0
0
0
0
% N
% Pro:
8
0
0
8
0
0
0
0
0
8
0
0
0
8
0
% P
% Gln:
0
0
8
0
8
0
8
0
8
8
0
0
0
8
0
% Q
% Arg:
43
0
0
8
0
8
8
0
50
0
8
8
0
0
0
% R
% Ser:
8
8
8
8
8
8
0
22
8
0
0
8
8
0
8
% S
% Thr:
8
0
0
0
0
43
0
0
0
0
0
0
8
0
0
% T
% Val:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
8
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
8
0
% W
% Tyr:
0
0
0
0
0
0
8
0
0
0
15
0
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _