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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
SMAD7
All Species:
30.61
Human Site:
T354
Identified Species:
51.79
UniProt:
O15105
Number Species:
13
Phosphosite Substitution
Charge Score:
-0.08
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
O15105
NP_005895.1
426
46426
T354
L
D
N
P
D
S
R
T
L
L
V
H
K
V
F
Chimpanzee
Pan troglodytes
XP_512124
426
46437
T354
L
D
N
P
D
S
R
T
L
L
V
H
K
V
F
Rhesus Macaque
Macaca mulatta
XP_001087560
426
46226
T354
L
D
N
P
D
S
R
T
L
L
V
H
K
V
F
Dog
Lupus familis
XP_850493
430
46498
T358
L
D
N
P
D
S
R
T
L
L
V
H
K
V
F
Cat
Felis silvestris
Mouse
Mus musculus
O35253
426
46423
T354
L
D
N
P
D
S
R
T
L
L
V
H
K
V
F
Rat
Rattus norvegicus
O88406
426
46439
T354
L
D
N
P
D
S
R
T
L
L
V
H
K
V
F
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001509923
178
20616
L107
D
N
P
D
S
R
T
L
L
V
H
K
V
F
P
Chicken
Gallus gallus
Q9W734
431
47806
T358
L
D
I
P
N
C
R
T
L
I
V
R
K
V
M
Frog
Xenopus laevis
NP_001081017
382
42694
T310
L
D
N
P
D
S
R
T
L
L
V
H
K
V
F
Zebra Danio
Brachydanio rerio
Q9I9P9
468
52435
H370
C
N
Q
R
Y
G
W
H
P
A
T
V
C
K
I
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
P42003
455
50486
H357
C
N
Y
H
H
G
F
H
P
S
T
V
C
K
I
Honey Bee
Apis mellifera
XP_396816
251
28007
G180
L
V
Y
R
V
P
P
G
F
C
L
N
I
F
D
Nematode Worm
Caenorhab. elegans
P45897
570
63351
R481
M
Q
M
L
R
R
S
R
S
S
N
E
A
V
R
Sea Urchin
Strong. purpuratus
XP_798238
371
42051
V299
P
H
S
R
T
F
T
V
H
K
L
S
P
G
F
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Baker's Yeast
Sacchar. cerevisiae
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
99.7
94.8
95.8
N.A.
98.1
97.8
N.A.
40.8
51.5
77.2
22.6
N.A.
20.2
30.7
20.5
43.4
Protein Similarity:
100
99.7
96.7
96.7
N.A.
98.5
98.5
N.A.
41.3
64.5
81.9
37.3
N.A.
36
39.6
35
57.2
P-Site Identity:
100
100
100
100
N.A.
100
100
N.A.
6.6
60
100
0
N.A.
0
6.6
6.6
6.6
P-Site Similarity:
100
100
100
100
N.A.
100
100
N.A.
20
73.3
100
6.6
N.A.
6.6
20
13.3
20
Percent
Protein Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
0
0
0
0
0
0
0
0
8
0
0
8
0
0
% A
% Cys:
15
0
0
0
0
8
0
0
0
8
0
0
15
0
0
% C
% Asp:
8
58
0
8
50
0
0
0
0
0
0
0
0
0
8
% D
% Glu:
0
0
0
0
0
0
0
0
0
0
0
8
0
0
0
% E
% Phe:
0
0
0
0
0
8
8
0
8
0
0
0
0
15
58
% F
% Gly:
0
0
0
0
0
15
0
8
0
0
0
0
0
8
0
% G
% His:
0
8
0
8
8
0
0
15
8
0
8
50
0
0
0
% H
% Ile:
0
0
8
0
0
0
0
0
0
8
0
0
8
0
15
% I
% Lys:
0
0
0
0
0
0
0
0
0
8
0
8
58
15
0
% K
% Leu:
65
0
0
8
0
0
0
8
65
50
15
0
0
0
0
% L
% Met:
8
0
8
0
0
0
0
0
0
0
0
0
0
0
8
% M
% Asn:
0
22
50
0
8
0
0
0
0
0
8
8
0
0
0
% N
% Pro:
8
0
8
58
0
8
8
0
15
0
0
0
8
0
8
% P
% Gln:
0
8
8
0
0
0
0
0
0
0
0
0
0
0
0
% Q
% Arg:
0
0
0
22
8
15
58
8
0
0
0
8
0
0
8
% R
% Ser:
0
0
8
0
8
50
8
0
8
15
0
8
0
0
0
% S
% Thr:
0
0
0
0
8
0
15
58
0
0
15
0
0
0
0
% T
% Val:
0
8
0
0
8
0
0
8
0
8
58
15
8
65
0
% V
% Trp:
0
0
0
0
0
0
8
0
0
0
0
0
0
0
0
% W
% Tyr:
0
0
15
0
8
0
0
0
0
0
0
0
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _