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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
SMAD7
All Species:
22.73
Human Site:
Y214
Identified Species:
38.46
UniProt:
O15105
Number Species:
13
Phosphosite Substitution
Charge Score:
0
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
O15105
NP_005895.1
426
46426
Y214
P
P
P
P
Y
S
R
Y
P
M
D
F
L
K
P
Chimpanzee
Pan troglodytes
XP_512124
426
46437
Y214
P
P
P
P
Y
S
R
Y
P
M
D
F
L
K
P
Rhesus Macaque
Macaca mulatta
XP_001087560
426
46226
Y214
P
P
P
P
Y
S
R
Y
P
M
D
F
L
K
P
Dog
Lupus familis
XP_850493
430
46498
R218
S
P
P
P
P
Y
S
R
Y
P
M
D
F
L
K
Cat
Felis silvestris
Mouse
Mus musculus
O35253
426
46423
Y214
P
P
P
P
Y
S
R
Y
P
M
D
F
L
K
P
Rat
Rattus norvegicus
O88406
426
46439
Y214
P
P
P
P
Y
S
R
Y
P
M
D
F
L
K
P
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001509923
178
20616
Chicken
Gallus gallus
Q9W734
431
47806
P218
P
P
Y
S
R
L
S
P
N
D
E
Q
K
P
L
Frog
Xenopus laevis
NP_001081017
382
42694
Y170
P
P
P
P
Y
T
R
Y
P
M
D
F
L
K
P
Zebra Danio
Brachydanio rerio
Q9I9P9
468
52435
D230
P
P
G
Y
I
S
E
D
G
E
A
S
D
Q
Q
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
P42003
455
50486
L217
P
N
S
P
Y
D
S
L
A
G
T
P
P
P
A
Honey Bee
Apis mellifera
XP_396816
251
28007
C40
A
K
D
P
V
Y
I
C
C
N
P
Y
H
W
S
Nematode Worm
Caenorhab. elegans
P45897
570
63351
P341
D
L
N
Q
I
Y
V
P
T
P
P
Q
L
L
D
Sea Urchin
Strong. purpuratus
XP_798238
371
42051
Q159
A
F
E
R
S
K
T
Q
E
T
E
E
D
A
P
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Baker's Yeast
Sacchar. cerevisiae
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
99.7
94.8
95.8
N.A.
98.1
97.8
N.A.
40.8
51.5
77.2
22.6
N.A.
20.2
30.7
20.5
43.4
Protein Similarity:
100
99.7
96.7
96.7
N.A.
98.5
98.5
N.A.
41.3
64.5
81.9
37.3
N.A.
36
39.6
35
57.2
P-Site Identity:
100
100
100
20
N.A.
100
100
N.A.
0
13.3
93.3
20
N.A.
20
6.6
6.6
6.6
P-Site Similarity:
100
100
100
20
N.A.
100
100
N.A.
0
20
100
26.6
N.A.
20
13.3
6.6
13.3
Percent
Protein Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
15
0
0
0
0
0
0
0
8
0
8
0
0
8
8
% A
% Cys:
0
0
0
0
0
0
0
8
8
0
0
0
0
0
0
% C
% Asp:
8
0
8
0
0
8
0
8
0
8
43
8
15
0
8
% D
% Glu:
0
0
8
0
0
0
8
0
8
8
15
8
0
0
0
% E
% Phe:
0
8
0
0
0
0
0
0
0
0
0
43
8
0
0
% F
% Gly:
0
0
8
0
0
0
0
0
8
8
0
0
0
0
0
% G
% His:
0
0
0
0
0
0
0
0
0
0
0
0
8
0
0
% H
% Ile:
0
0
0
0
15
0
8
0
0
0
0
0
0
0
0
% I
% Lys:
0
8
0
0
0
8
0
0
0
0
0
0
8
43
8
% K
% Leu:
0
8
0
0
0
8
0
8
0
0
0
0
50
15
8
% L
% Met:
0
0
0
0
0
0
0
0
0
43
8
0
0
0
0
% M
% Asn:
0
8
8
0
0
0
0
0
8
8
0
0
0
0
0
% N
% Pro:
65
65
50
65
8
0
0
15
43
15
15
8
8
15
50
% P
% Gln:
0
0
0
8
0
0
0
8
0
0
0
15
0
8
8
% Q
% Arg:
0
0
0
8
8
0
43
8
0
0
0
0
0
0
0
% R
% Ser:
8
0
8
8
8
43
22
0
0
0
0
8
0
0
8
% S
% Thr:
0
0
0
0
0
8
8
0
8
8
8
0
0
0
0
% T
% Val:
0
0
0
0
8
0
8
0
0
0
0
0
0
0
0
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
8
0
% W
% Tyr:
0
0
8
8
50
22
0
43
8
0
0
8
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _