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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
SMAD7
All Species:
19.09
Human Site:
Y240
Identified Species:
32.31
UniProt:
O15105
Number Species:
13
Phosphosite Substitution
Charge Score:
0
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
O15105
NP_005895.1
426
46426
Y240
A
E
T
G
G
T
N
Y
L
A
P
G
G
L
S
Chimpanzee
Pan troglodytes
XP_512124
426
46437
Y240
A
E
T
G
G
T
N
Y
L
A
P
G
G
L
S
Rhesus Macaque
Macaca mulatta
XP_001087560
426
46226
Y240
A
E
T
G
G
T
N
Y
L
A
P
G
G
L
S
Dog
Lupus familis
XP_850493
430
46498
F244
A
E
T
G
G
T
N
F
L
A
P
G
G
L
S
Cat
Felis silvestris
Mouse
Mus musculus
O35253
426
46423
Y240
A
E
T
G
G
T
N
Y
L
A
P
G
G
L
S
Rat
Rattus norvegicus
O88406
426
46439
Y240
D
E
T
G
G
T
N
Y
L
A
P
G
G
L
S
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001509923
178
20616
Chicken
Gallus gallus
Q9W734
431
47806
N244
T
E
A
T
N
S
P
N
V
T
P
G
E
F
S
Frog
Xenopus laevis
NP_001081017
382
42694
F196
T
E
T
G
G
T
N
F
L
A
P
E
G
L
S
Zebra Danio
Brachydanio rerio
Q9I9P9
468
52435
S256
E
L
S
P
S
T
L
S
P
V
N
H
G
M
D
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
P42003
455
50486
L243
P
N
D
G
G
Q
L
L
D
A
Q
M
G
D
V
Honey Bee
Apis mellifera
XP_396816
251
28007
L66
Y
C
L
I
A
D
R
L
R
P
E
G
E
T
G
Nematode Worm
Caenorhab. elegans
P45897
570
63351
K367
T
P
I
G
E
T
F
K
V
S
A
R
D
H
G
Sea Urchin
Strong. purpuratus
XP_798238
371
42051
E185
E
T
G
N
T
P
T
E
R
R
Q
P
Y
A
N
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Baker's Yeast
Sacchar. cerevisiae
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
99.7
94.8
95.8
N.A.
98.1
97.8
N.A.
40.8
51.5
77.2
22.6
N.A.
20.2
30.7
20.5
43.4
Protein Similarity:
100
99.7
96.7
96.7
N.A.
98.5
98.5
N.A.
41.3
64.5
81.9
37.3
N.A.
36
39.6
35
57.2
P-Site Identity:
100
100
100
93.3
N.A.
100
93.3
N.A.
0
26.6
80
13.3
N.A.
26.6
6.6
13.3
0
P-Site Similarity:
100
100
100
100
N.A.
100
93.3
N.A.
0
40
86.6
26.6
N.A.
26.6
6.6
26.6
6.6
Percent
Protein Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
36
0
8
0
8
0
0
0
0
58
8
0
0
8
0
% A
% Cys:
0
8
0
0
0
0
0
0
0
0
0
0
0
0
0
% C
% Asp:
8
0
8
0
0
8
0
0
8
0
0
0
8
8
8
% D
% Glu:
15
58
0
0
8
0
0
8
0
0
8
8
15
0
0
% E
% Phe:
0
0
0
0
0
0
8
15
0
0
0
0
0
8
0
% F
% Gly:
0
0
8
65
58
0
0
0
0
0
0
58
65
0
15
% G
% His:
0
0
0
0
0
0
0
0
0
0
0
8
0
8
0
% H
% Ile:
0
0
8
8
0
0
0
0
0
0
0
0
0
0
0
% I
% Lys:
0
0
0
0
0
0
0
8
0
0
0
0
0
0
0
% K
% Leu:
0
8
8
0
0
0
15
15
50
0
0
0
0
50
0
% L
% Met:
0
0
0
0
0
0
0
0
0
0
0
8
0
8
0
% M
% Asn:
0
8
0
8
8
0
50
8
0
0
8
0
0
0
8
% N
% Pro:
8
8
0
8
0
8
8
0
8
8
58
8
0
0
0
% P
% Gln:
0
0
0
0
0
8
0
0
0
0
15
0
0
0
0
% Q
% Arg:
0
0
0
0
0
0
8
0
15
8
0
8
0
0
0
% R
% Ser:
0
0
8
0
8
8
0
8
0
8
0
0
0
0
58
% S
% Thr:
22
8
50
8
8
65
8
0
0
8
0
0
0
8
0
% T
% Val:
0
0
0
0
0
0
0
0
15
8
0
0
0
0
8
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
8
0
0
0
0
0
0
36
0
0
0
0
8
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _