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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: NPC1 All Species: 11.21
Human Site: S344 Identified Species: 24.67
UniProt: O15118 Number Species: 10
    Phosphosite Substitution
    Charge Score: 0
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens O15118 NP_000262.2 1278 142167 S344 R L F T R W G S F C V R N P G
Chimpanzee Pan troglodytes XP_001155285 1277 141871 S344 R L F T R W G S F C V R N P G
Rhesus Macaque Macaca mulatta
Dog Lupus familis
Cat Felis silvestris
Mouse Mus musculus O35604 1278 142870 A345 R M F T K W G A F C V R N P T
Rat Rattus norvegicus Q6T3U3 1331 146397 T346 R F F Q N W G T R V A S W P L
Wallaby Macropus eugenll
Platypus Ornith. anatinus
Chicken Gallus gallus XP_419162 1261 140678 I338 V R N P R P V I L F S V V F I
Frog Xenopus laevis
Zebra Danio Brachydanio rerio XP_001919958 1164 130467 H289 E K N Y F D Q H F G P F F R T
Tiger Blowfish Takifugu rubipres
Fruit Fly Dros. melanogaster NP_609357 1287 143273 T347 T F F T K W G T Y F A S N P G
Honey Bee Apis mellifera XP_624752 1358 152373 L345 A S R P W F V L F L G F L F I
Nematode Worm Caenorhab. elegans Q19127 1383 155438 M347 N N A R D I G M M A G R N P K
Sea Urchin Strong. purpuratus XP_780036 1332 147422 T380 L C F R K L G T L V A G H P H
Poplar Tree Populus trichocarpa
Maize Zea mays
Rice Oryza sativa
Thale Cress Arabidopsis thaliana
Baker's Yeast Sacchar. cerevisiae Q12200 1170 132626 V295 M I V D D D I V P E S G S L D
Red Bread Mold Neurospora crassa
Conservation
Percent
Protein Identity: 100 98.9 N.A. N.A. N.A. 86.2 39.1 N.A. N.A. 78 N.A. 63.8 N.A. 45.1 43 28 49.1
Protein Similarity: 100 99.4 N.A. N.A. N.A. 93.3 58.3 N.A. N.A. 87.7 N.A. 76 N.A. 63.2 60.9 47.7 65.5
P-Site Identity: 100 100 N.A. N.A. N.A. 73.3 33.3 N.A. N.A. 6.6 N.A. 6.6 N.A. 46.6 6.6 26.6 20
P-Site Similarity: 100 100 N.A. N.A. N.A. 93.3 40 N.A. N.A. 6.6 N.A. 6.6 N.A. 66.6 13.3 26.6 40
Percent
Protein Identity: N.A. N.A. N.A. N.A. 32.3 N.A.
Protein Similarity: N.A. N.A. N.A. N.A. 50.8 N.A.
P-Site Identity: N.A. N.A. N.A. N.A. 0 N.A.
P-Site Similarity: N.A. N.A. N.A. N.A. 13.3 N.A.
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 10 0 10 0 0 0 0 10 0 10 28 0 0 0 0 % A
% Cys: 0 10 0 0 0 0 0 0 0 28 0 0 0 0 0 % C
% Asp: 0 0 0 10 19 19 0 0 0 0 0 0 0 0 10 % D
% Glu: 10 0 0 0 0 0 0 0 0 10 0 0 0 0 0 % E
% Phe: 0 19 55 0 10 10 0 0 46 19 0 19 10 19 0 % F
% Gly: 0 0 0 0 0 0 64 0 0 10 19 19 0 0 28 % G
% His: 0 0 0 0 0 0 0 10 0 0 0 0 10 0 10 % H
% Ile: 0 10 0 0 0 10 10 10 0 0 0 0 0 0 19 % I
% Lys: 0 10 0 0 28 0 0 0 0 0 0 0 0 0 10 % K
% Leu: 10 19 0 0 0 10 0 10 19 10 0 0 10 10 10 % L
% Met: 10 10 0 0 0 0 0 10 10 0 0 0 0 0 0 % M
% Asn: 10 10 19 0 10 0 0 0 0 0 0 0 46 0 0 % N
% Pro: 0 0 0 19 0 10 0 0 10 0 10 0 0 64 0 % P
% Gln: 0 0 0 10 0 0 10 0 0 0 0 0 0 0 0 % Q
% Arg: 37 10 10 19 28 0 0 0 10 0 0 37 0 10 0 % R
% Ser: 0 10 0 0 0 0 0 19 0 0 19 19 10 0 0 % S
% Thr: 10 0 0 37 0 0 0 28 0 0 0 0 0 0 19 % T
% Val: 10 0 10 0 0 0 19 10 0 19 28 10 10 0 0 % V
% Trp: 0 0 0 0 10 46 0 0 0 0 0 0 10 0 0 % W
% Tyr: 0 0 0 10 0 0 0 0 10 0 0 0 0 0 0 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _