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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
NPC1
All Species:
24.24
Human Site:
S386
Identified Species:
53.33
UniProt:
O15118
Number Species:
10
Phosphosite Substitution
Charge Score:
0.2
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
O15118
NP_000262.2
1278
142167
S386
D
L
W
S
A
P
S
S
Q
A
R
L
E
K
E
Chimpanzee
Pan troglodytes
XP_001155285
1277
141871
S386
D
L
W
S
A
P
S
S
Q
A
R
L
E
K
E
Rhesus Macaque
Macaca mulatta
Dog
Lupus familis
Cat
Felis silvestris
Mouse
Mus musculus
O35604
1278
142870
S387
E
L
W
S
A
P
H
S
Q
A
R
L
E
K
E
Rat
Rattus norvegicus
Q6T3U3
1331
146397
S388
E
L
W
S
A
P
K
S
Q
A
R
K
E
K
S
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
Chicken
Gallus gallus
XP_419162
1261
140678
D380
R
K
E
K
E
Y
F
D
K
H
F
G
P
F
F
Frog
Xenopus laevis
Zebra Danio
Brachydanio rerio
XP_001919958
1164
130467
H331
I
L
N
L
S
L
L
H
Q
V
L
D
L
Q
L
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
NP_609357
1287
143273
S389
K
L
W
A
S
P
N
S
K
S
R
L
E
R
E
Honey Bee
Apis mellifera
XP_624752
1358
152373
D387
R
V
E
K
E
Y
F
D
Q
H
F
E
P
F
Y
Nematode Worm
Caenorhab. elegans
Q19127
1383
155438
S389
D
M
W
S
S
P
R
S
R
A
R
Q
E
E
M
Sea Urchin
Strong. purpuratus
XP_780036
1332
147422
S422
E
L
W
S
P
P
T
S
E
S
R
L
E
K
A
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Baker's Yeast
Sacchar. cerevisiae
Q12200
1170
132626
N337
V
G
Q
F
S
V
E
N
P
Y
K
I
L
I
T
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
98.9
N.A.
N.A.
N.A.
86.2
39.1
N.A.
N.A.
78
N.A.
63.8
N.A.
45.1
43
28
49.1
Protein Similarity:
100
99.4
N.A.
N.A.
N.A.
93.3
58.3
N.A.
N.A.
87.7
N.A.
76
N.A.
63.2
60.9
47.7
65.5
P-Site Identity:
100
100
N.A.
N.A.
N.A.
86.6
73.3
N.A.
N.A.
0
N.A.
13.3
N.A.
53.3
6.6
53.3
60
P-Site Similarity:
100
100
N.A.
N.A.
N.A.
93.3
80
N.A.
N.A.
6.6
N.A.
26.6
N.A.
93.3
13.3
80
86.6
Percent
Protein Identity:
N.A.
N.A.
N.A.
N.A.
32.3
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
N.A.
50.8
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
N.A.
0
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
N.A.
26.6
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
0
0
10
37
0
0
0
0
46
0
0
0
0
10
% A
% Cys:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% C
% Asp:
28
0
0
0
0
0
0
19
0
0
0
10
0
0
0
% D
% Glu:
28
0
19
0
19
0
10
0
10
0
0
10
64
10
37
% E
% Phe:
0
0
0
10
0
0
19
0
0
0
19
0
0
19
10
% F
% Gly:
0
10
0
0
0
0
0
0
0
0
0
10
0
0
0
% G
% His:
0
0
0
0
0
0
10
10
0
19
0
0
0
0
0
% H
% Ile:
10
0
0
0
0
0
0
0
0
0
0
10
0
10
0
% I
% Lys:
10
10
0
19
0
0
10
0
19
0
10
10
0
46
0
% K
% Leu:
0
64
0
10
0
10
10
0
0
0
10
46
19
0
10
% L
% Met:
0
10
0
0
0
0
0
0
0
0
0
0
0
0
10
% M
% Asn:
0
0
10
0
0
0
10
10
0
0
0
0
0
0
0
% N
% Pro:
0
0
0
0
10
64
0
0
10
0
0
0
19
0
0
% P
% Gln:
0
0
10
0
0
0
0
0
55
0
0
10
0
10
0
% Q
% Arg:
19
0
0
0
0
0
10
0
10
0
64
0
0
10
0
% R
% Ser:
0
0
0
55
37
0
19
64
0
19
0
0
0
0
10
% S
% Thr:
0
0
0
0
0
0
10
0
0
0
0
0
0
0
10
% T
% Val:
10
10
0
0
0
10
0
0
0
10
0
0
0
0
0
% V
% Trp:
0
0
64
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
0
0
0
0
0
19
0
0
0
10
0
0
0
0
10
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _