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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
NPC1
All Species:
10
Human Site:
S493
Identified Species:
22
UniProt:
O15118
Number Species:
10
Phosphosite Substitution
Charge Score:
0.1
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
O15118
NP_000262.2
1278
142167
S493
N
Y
F
Q
N
S
H
S
V
L
D
H
K
K
G
Chimpanzee
Pan troglodytes
XP_001155285
1277
141871
S493
N
Y
F
Q
N
S
H
S
V
L
D
H
K
K
G
Rhesus Macaque
Macaca mulatta
Dog
Lupus familis
Cat
Felis silvestris
Mouse
Mus musculus
O35604
1278
142870
A494
N
Y
F
Q
N
S
H
A
V
L
D
S
Q
V
G
Rat
Rattus norvegicus
Q6T3U3
1331
146397
M502
Q
N
N
R
T
L
L
M
L
T
A
N
Q
T
L
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
Chicken
Gallus gallus
XP_419162
1261
140678
S477
N
Y
F
Q
N
S
H
S
V
L
D
H
S
V
G
Frog
Xenopus laevis
Zebra Danio
Brachydanio rerio
XP_001919958
1164
130467
G425
R
L
H
D
P
C
M
G
T
F
G
G
P
V
F
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
NP_609357
1287
143273
F490
V
Q
S
I
W
G
Y
F
G
D
D
R
E
R
L
Honey Bee
Apis mellifera
XP_624752
1358
152373
I484
W
G
Y
W
Q
D
S
I
E
T
F
D
F
S
T
Nematode Worm
Caenorhab. elegans
Q19127
1383
155438
S501
S
N
K
E
E
T
V
S
E
D
D
D
A
F
D
Sea Urchin
Strong. purpuratus
XP_780036
1332
147422
L533
F
Q
N
S
H
E
K
L
D
R
V
I
M
D
P
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Baker's Yeast
Sacchar. cerevisiae
Q12200
1170
132626
E430
T
E
E
L
Q
S
S
E
N
I
G
Y
Q
D
L
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
98.9
N.A.
N.A.
N.A.
86.2
39.1
N.A.
N.A.
78
N.A.
63.8
N.A.
45.1
43
28
49.1
Protein Similarity:
100
99.4
N.A.
N.A.
N.A.
93.3
58.3
N.A.
N.A.
87.7
N.A.
76
N.A.
63.2
60.9
47.7
65.5
P-Site Identity:
100
100
N.A.
N.A.
N.A.
73.3
0
N.A.
N.A.
86.6
N.A.
0
N.A.
6.6
0
13.3
0
P-Site Similarity:
100
100
N.A.
N.A.
N.A.
86.6
26.6
N.A.
N.A.
86.6
N.A.
0
N.A.
26.6
6.6
33.3
6.6
Percent
Protein Identity:
N.A.
N.A.
N.A.
N.A.
32.3
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
N.A.
50.8
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
N.A.
6.6
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
N.A.
26.6
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
0
0
0
0
0
0
10
0
0
10
0
10
0
0
% A
% Cys:
0
0
0
0
0
10
0
0
0
0
0
0
0
0
0
% C
% Asp:
0
0
0
10
0
10
0
0
10
19
55
19
0
19
10
% D
% Glu:
0
10
10
10
10
10
0
10
19
0
0
0
10
0
0
% E
% Phe:
10
0
37
0
0
0
0
10
0
10
10
0
10
10
10
% F
% Gly:
0
10
0
0
0
10
0
10
10
0
19
10
0
0
37
% G
% His:
0
0
10
0
10
0
37
0
0
0
0
28
0
0
0
% H
% Ile:
0
0
0
10
0
0
0
10
0
10
0
10
0
0
0
% I
% Lys:
0
0
10
0
0
0
10
0
0
0
0
0
19
19
0
% K
% Leu:
0
10
0
10
0
10
10
10
10
37
0
0
0
0
28
% L
% Met:
0
0
0
0
0
0
10
10
0
0
0
0
10
0
0
% M
% Asn:
37
19
19
0
37
0
0
0
10
0
0
10
0
0
0
% N
% Pro:
0
0
0
0
10
0
0
0
0
0
0
0
10
0
10
% P
% Gln:
10
19
0
37
19
0
0
0
0
0
0
0
28
0
0
% Q
% Arg:
10
0
0
10
0
0
0
0
0
10
0
10
0
10
0
% R
% Ser:
10
0
10
10
0
46
19
37
0
0
0
10
10
10
0
% S
% Thr:
10
0
0
0
10
10
0
0
10
19
0
0
0
10
10
% T
% Val:
10
0
0
0
0
0
10
0
37
0
10
0
0
28
0
% V
% Trp:
10
0
0
10
10
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
0
37
10
0
0
0
10
0
0
0
0
10
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _