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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: NPC1 All Species: 10
Human Site: S493 Identified Species: 22
UniProt: O15118 Number Species: 10
    Phosphosite Substitution
    Charge Score: 0.1
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens O15118 NP_000262.2 1278 142167 S493 N Y F Q N S H S V L D H K K G
Chimpanzee Pan troglodytes XP_001155285 1277 141871 S493 N Y F Q N S H S V L D H K K G
Rhesus Macaque Macaca mulatta
Dog Lupus familis
Cat Felis silvestris
Mouse Mus musculus O35604 1278 142870 A494 N Y F Q N S H A V L D S Q V G
Rat Rattus norvegicus Q6T3U3 1331 146397 M502 Q N N R T L L M L T A N Q T L
Wallaby Macropus eugenll
Platypus Ornith. anatinus
Chicken Gallus gallus XP_419162 1261 140678 S477 N Y F Q N S H S V L D H S V G
Frog Xenopus laevis
Zebra Danio Brachydanio rerio XP_001919958 1164 130467 G425 R L H D P C M G T F G G P V F
Tiger Blowfish Takifugu rubipres
Fruit Fly Dros. melanogaster NP_609357 1287 143273 F490 V Q S I W G Y F G D D R E R L
Honey Bee Apis mellifera XP_624752 1358 152373 I484 W G Y W Q D S I E T F D F S T
Nematode Worm Caenorhab. elegans Q19127 1383 155438 S501 S N K E E T V S E D D D A F D
Sea Urchin Strong. purpuratus XP_780036 1332 147422 L533 F Q N S H E K L D R V I M D P
Poplar Tree Populus trichocarpa
Maize Zea mays
Rice Oryza sativa
Thale Cress Arabidopsis thaliana
Baker's Yeast Sacchar. cerevisiae Q12200 1170 132626 E430 T E E L Q S S E N I G Y Q D L
Red Bread Mold Neurospora crassa
Conservation
Percent
Protein Identity: 100 98.9 N.A. N.A. N.A. 86.2 39.1 N.A. N.A. 78 N.A. 63.8 N.A. 45.1 43 28 49.1
Protein Similarity: 100 99.4 N.A. N.A. N.A. 93.3 58.3 N.A. N.A. 87.7 N.A. 76 N.A. 63.2 60.9 47.7 65.5
P-Site Identity: 100 100 N.A. N.A. N.A. 73.3 0 N.A. N.A. 86.6 N.A. 0 N.A. 6.6 0 13.3 0
P-Site Similarity: 100 100 N.A. N.A. N.A. 86.6 26.6 N.A. N.A. 86.6 N.A. 0 N.A. 26.6 6.6 33.3 6.6
Percent
Protein Identity: N.A. N.A. N.A. N.A. 32.3 N.A.
Protein Similarity: N.A. N.A. N.A. N.A. 50.8 N.A.
P-Site Identity: N.A. N.A. N.A. N.A. 6.6 N.A.
P-Site Similarity: N.A. N.A. N.A. N.A. 26.6 N.A.
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 0 0 0 0 0 0 0 10 0 0 10 0 10 0 0 % A
% Cys: 0 0 0 0 0 10 0 0 0 0 0 0 0 0 0 % C
% Asp: 0 0 0 10 0 10 0 0 10 19 55 19 0 19 10 % D
% Glu: 0 10 10 10 10 10 0 10 19 0 0 0 10 0 0 % E
% Phe: 10 0 37 0 0 0 0 10 0 10 10 0 10 10 10 % F
% Gly: 0 10 0 0 0 10 0 10 10 0 19 10 0 0 37 % G
% His: 0 0 10 0 10 0 37 0 0 0 0 28 0 0 0 % H
% Ile: 0 0 0 10 0 0 0 10 0 10 0 10 0 0 0 % I
% Lys: 0 0 10 0 0 0 10 0 0 0 0 0 19 19 0 % K
% Leu: 0 10 0 10 0 10 10 10 10 37 0 0 0 0 28 % L
% Met: 0 0 0 0 0 0 10 10 0 0 0 0 10 0 0 % M
% Asn: 37 19 19 0 37 0 0 0 10 0 0 10 0 0 0 % N
% Pro: 0 0 0 0 10 0 0 0 0 0 0 0 10 0 10 % P
% Gln: 10 19 0 37 19 0 0 0 0 0 0 0 28 0 0 % Q
% Arg: 10 0 0 10 0 0 0 0 0 10 0 10 0 10 0 % R
% Ser: 10 0 10 10 0 46 19 37 0 0 0 10 10 10 0 % S
% Thr: 10 0 0 0 10 10 0 0 10 19 0 0 0 10 10 % T
% Val: 10 0 0 0 0 0 10 0 37 0 10 0 0 28 0 % V
% Trp: 10 0 0 10 10 0 0 0 0 0 0 0 0 0 0 % W
% Tyr: 0 37 10 0 0 0 10 0 0 0 0 10 0 0 0 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _