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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
NPC1
All Species:
22.12
Human Site:
S865
Identified Species:
48.67
UniProt:
O15118
Number Species:
10
Phosphosite Substitution
Charge Score:
0
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
O15118
NP_000262.2
1278
142167
S865
I
G
L
D
Q
S
L
S
M
P
D
D
S
Y
M
Chimpanzee
Pan troglodytes
XP_001155285
1277
141871
S865
I
G
L
D
Q
S
L
S
M
P
D
D
S
Y
V
Rhesus Macaque
Macaca mulatta
Dog
Lupus familis
Cat
Felis silvestris
Mouse
Mus musculus
O35604
1278
142870
S866
I
G
L
D
Q
S
L
S
M
P
N
D
S
Y
V
Rat
Rattus norvegicus
Q6T3U3
1331
146397
A876
V
G
L
D
Q
E
L
A
L
P
K
D
S
Y
L
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
Chicken
Gallus gallus
XP_419162
1261
140678
S849
I
G
L
D
Q
S
L
S
M
P
D
D
S
Y
V
Frog
Xenopus laevis
Zebra Danio
Brachydanio rerio
XP_001919958
1164
130467
N762
P
D
D
S
Y
V
L
N
Y
F
G
N
L
S
K
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
NP_609357
1287
143273
A866
I
G
L
D
Q
E
L
A
M
P
Q
D
S
F
V
Honey Bee
Apis mellifera
XP_624752
1358
152373
S859
I
G
L
D
Q
E
L
S
M
P
E
D
S
F
V
Nematode Worm
Caenorhab. elegans
Q19127
1383
155438
A885
V
G
F
D
Q
S
M
A
F
T
E
K
S
Y
I
Sea Urchin
Strong. purpuratus
XP_780036
1332
147422
S904
V
G
L
D
Q
K
L
S
M
P
E
D
S
Y
M
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Baker's Yeast
Sacchar. cerevisiae
Q12200
1170
132626
L767
F
F
T
S
L
V
F
L
P
E
I
Q
F
G
L
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
98.9
N.A.
N.A.
N.A.
86.2
39.1
N.A.
N.A.
78
N.A.
63.8
N.A.
45.1
43
28
49.1
Protein Similarity:
100
99.4
N.A.
N.A.
N.A.
93.3
58.3
N.A.
N.A.
87.7
N.A.
76
N.A.
63.2
60.9
47.7
65.5
P-Site Identity:
100
93.3
N.A.
N.A.
N.A.
86.6
60
N.A.
N.A.
93.3
N.A.
6.6
N.A.
66.6
73.3
40
80
P-Site Similarity:
100
100
N.A.
N.A.
N.A.
100
86.6
N.A.
N.A.
100
N.A.
20
N.A.
86.6
93.3
73.3
93.3
Percent
Protein Identity:
N.A.
N.A.
N.A.
N.A.
32.3
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
N.A.
50.8
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
N.A.
0
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
N.A.
6.6
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
0
0
0
0
0
0
28
0
0
0
0
0
0
0
% A
% Cys:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% C
% Asp:
0
10
10
82
0
0
0
0
0
0
28
73
0
0
0
% D
% Glu:
0
0
0
0
0
28
0
0
0
10
28
0
0
0
0
% E
% Phe:
10
10
10
0
0
0
10
0
10
10
0
0
10
19
0
% F
% Gly:
0
82
0
0
0
0
0
0
0
0
10
0
0
10
0
% G
% His:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% H
% Ile:
55
0
0
0
0
0
0
0
0
0
10
0
0
0
10
% I
% Lys:
0
0
0
0
0
10
0
0
0
0
10
10
0
0
10
% K
% Leu:
0
0
73
0
10
0
82
10
10
0
0
0
10
0
19
% L
% Met:
0
0
0
0
0
0
10
0
64
0
0
0
0
0
19
% M
% Asn:
0
0
0
0
0
0
0
10
0
0
10
10
0
0
0
% N
% Pro:
10
0
0
0
0
0
0
0
10
73
0
0
0
0
0
% P
% Gln:
0
0
0
0
82
0
0
0
0
0
10
10
0
0
0
% Q
% Arg:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% R
% Ser:
0
0
0
19
0
46
0
55
0
0
0
0
82
10
0
% S
% Thr:
0
0
10
0
0
0
0
0
0
10
0
0
0
0
0
% T
% Val:
28
0
0
0
0
19
0
0
0
0
0
0
0
0
46
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
0
0
0
0
10
0
0
0
10
0
0
0
0
64
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _