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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
NPC1
All Species:
15.45
Human Site:
T1270
Identified Species:
34
UniProt:
O15118
Number Species:
10
Phosphosite Substitution
Charge Score:
-0.1
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
O15118
NP_000262.2
1278
142167
T1270
T
E
E
R
Y
K
G
T
E
R
E
R
L
L
N
Chimpanzee
Pan troglodytes
XP_001155285
1277
141871
T1269
T
E
E
R
Y
K
G
T
E
R
E
R
L
L
N
Rhesus Macaque
Macaca mulatta
Dog
Lupus familis
Cat
Felis silvestris
Mouse
Mus musculus
O35604
1278
142870
T1270
T
Y
E
R
Y
R
G
T
E
R
E
R
L
L
N
Rat
Rattus norvegicus
Q6T3U3
1331
146397
A1285
E
K
L
A
S
E
A
A
V
A
P
E
P
S
C
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
Chicken
Gallus gallus
XP_419162
1261
140678
T1253
A
Q
E
R
S
R
G
T
E
R
E
R
L
L
Y
Frog
Xenopus laevis
Zebra Danio
Brachydanio rerio
XP_001919958
1164
130467
T1157
A
H
N
R
F
V
G
T
E
R
E
R
L
I
Y
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
NP_609357
1287
143273
H1279
H
S
Q
A
A
A
E
H
E
T
A
L
A
G
I
Honey Bee
Apis mellifera
XP_624752
1358
152373
N1271
H
K
R
A
M
Q
G
N
L
D
N
Q
T
Q
F
Nematode Worm
Caenorhab. elegans
Q19127
1383
155438
H1302
T
N
D
N
D
E
Q
H
D
A
C
V
L
S
P
Sea Urchin
Strong. purpuratus
XP_780036
1332
147422
G1311
E
Q
E
Q
A
R
G
G
R
R
G
A
D
N
E
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Baker's Yeast
Sacchar. cerevisiae
Q12200
1170
132626
R1162
L
F
G
G
E
S
Y
R
D
D
S
I
E
A
E
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
98.9
N.A.
N.A.
N.A.
86.2
39.1
N.A.
N.A.
78
N.A.
63.8
N.A.
45.1
43
28
49.1
Protein Similarity:
100
99.4
N.A.
N.A.
N.A.
93.3
58.3
N.A.
N.A.
87.7
N.A.
76
N.A.
63.2
60.9
47.7
65.5
P-Site Identity:
100
100
N.A.
N.A.
N.A.
86.6
0
N.A.
N.A.
66.6
N.A.
53.3
N.A.
6.6
6.6
13.3
20
P-Site Similarity:
100
100
N.A.
N.A.
N.A.
93.3
13.3
N.A.
N.A.
80
N.A.
66.6
N.A.
13.3
26.6
33.3
40
Percent
Protein Identity:
N.A.
N.A.
N.A.
N.A.
32.3
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
N.A.
50.8
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
N.A.
0
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
N.A.
6.6
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
19
0
0
28
19
10
10
10
0
19
10
10
10
10
0
% A
% Cys:
0
0
0
0
0
0
0
0
0
0
10
0
0
0
10
% C
% Asp:
0
0
10
0
10
0
0
0
19
19
0
0
10
0
0
% D
% Glu:
19
19
46
0
10
19
10
0
55
0
46
10
10
0
19
% E
% Phe:
0
10
0
0
10
0
0
0
0
0
0
0
0
0
10
% F
% Gly:
0
0
10
10
0
0
64
10
0
0
10
0
0
10
0
% G
% His:
19
10
0
0
0
0
0
19
0
0
0
0
0
0
0
% H
% Ile:
0
0
0
0
0
0
0
0
0
0
0
10
0
10
10
% I
% Lys:
0
19
0
0
0
19
0
0
0
0
0
0
0
0
0
% K
% Leu:
10
0
10
0
0
0
0
0
10
0
0
10
55
37
0
% L
% Met:
0
0
0
0
10
0
0
0
0
0
0
0
0
0
0
% M
% Asn:
0
10
10
10
0
0
0
10
0
0
10
0
0
10
28
% N
% Pro:
0
0
0
0
0
0
0
0
0
0
10
0
10
0
10
% P
% Gln:
0
19
10
10
0
10
10
0
0
0
0
10
0
10
0
% Q
% Arg:
0
0
10
46
0
28
0
10
10
55
0
46
0
0
0
% R
% Ser:
0
10
0
0
19
10
0
0
0
0
10
0
0
19
0
% S
% Thr:
37
0
0
0
0
0
0
46
0
10
0
0
10
0
0
% T
% Val:
0
0
0
0
0
10
0
0
10
0
0
10
0
0
0
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
0
10
0
0
28
0
10
0
0
0
0
0
0
0
19
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _