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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
NPC1
All Species:
25.15
Human Site:
T900
Identified Species:
55.33
UniProt:
O15118
Number Species:
10
Phosphosite Substitution
Charge Score:
0
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
O15118
NP_000262.2
1278
142167
T900
L
E
E
G
H
D
Y
T
S
S
K
G
Q
N
M
Chimpanzee
Pan troglodytes
XP_001155285
1277
141871
T900
L
E
E
G
H
D
Y
T
S
S
K
G
Q
N
M
Rhesus Macaque
Macaca mulatta
Dog
Lupus familis
Cat
Felis silvestris
Mouse
Mus musculus
O35604
1278
142870
S901
L
E
E
G
Y
N
Y
S
S
R
K
G
Q
N
M
Rat
Rattus norvegicus
Q6T3U3
1331
146397
S911
T
T
S
G
F
N
F
S
S
E
A
G
M
N
A
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
Chicken
Gallus gallus
XP_419162
1261
140678
T884
L
E
E
G
H
N
Y
T
S
L
E
G
Q
N
M
Frog
Xenopus laevis
Zebra Danio
Brachydanio rerio
XP_001919958
1164
130467
C797
F
E
G
Q
N
A
V
C
G
G
V
G
C
N
N
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
NP_609357
1287
143273
T901
L
K
G
D
L
A
Y
T
N
S
S
D
Q
N
L
Honey Bee
Apis mellifera
XP_624752
1358
152373
S894
V
K
E
G
L
N
Y
S
D
K
R
A
Q
N
L
Nematode Worm
Caenorhab. elegans
Q19127
1383
155438
H920
V
D
G
E
L
D
W
H
R
P
D
V
Q
N
K
Sea Urchin
Strong. purpuratus
XP_780036
1332
147422
T939
V
K
D
G
Y
D
Y
T
S
I
E
G
Q
N
K
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Baker's Yeast
Sacchar. cerevisiae
Q12200
1170
132626
P802
S
F
L
N
V
G
P
P
V
Y
M
V
V
K
N
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
98.9
N.A.
N.A.
N.A.
86.2
39.1
N.A.
N.A.
78
N.A.
63.8
N.A.
45.1
43
28
49.1
Protein Similarity:
100
99.4
N.A.
N.A.
N.A.
93.3
58.3
N.A.
N.A.
87.7
N.A.
76
N.A.
63.2
60.9
47.7
65.5
P-Site Identity:
100
100
N.A.
N.A.
N.A.
73.3
26.6
N.A.
N.A.
80
N.A.
20
N.A.
40
33.3
20
53.3
P-Site Similarity:
100
100
N.A.
N.A.
N.A.
93.3
46.6
N.A.
N.A.
93.3
N.A.
26.6
N.A.
60
73.3
40
86.6
Percent
Protein Identity:
N.A.
N.A.
N.A.
N.A.
32.3
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
N.A.
50.8
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
N.A.
0
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
N.A.
0
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
0
0
0
0
19
0
0
0
0
10
10
0
0
10
% A
% Cys:
0
0
0
0
0
0
0
10
0
0
0
0
10
0
0
% C
% Asp:
0
10
10
10
0
37
0
0
10
0
10
10
0
0
0
% D
% Glu:
0
46
46
10
0
0
0
0
0
10
19
0
0
0
0
% E
% Phe:
10
10
0
0
10
0
10
0
0
0
0
0
0
0
0
% F
% Gly:
0
0
28
64
0
10
0
0
10
10
0
64
0
0
0
% G
% His:
0
0
0
0
28
0
0
10
0
0
0
0
0
0
0
% H
% Ile:
0
0
0
0
0
0
0
0
0
10
0
0
0
0
0
% I
% Lys:
0
28
0
0
0
0
0
0
0
10
28
0
0
10
19
% K
% Leu:
46
0
10
0
28
0
0
0
0
10
0
0
0
0
19
% L
% Met:
0
0
0
0
0
0
0
0
0
0
10
0
10
0
37
% M
% Asn:
0
0
0
10
10
37
0
0
10
0
0
0
0
91
19
% N
% Pro:
0
0
0
0
0
0
10
10
0
10
0
0
0
0
0
% P
% Gln:
0
0
0
10
0
0
0
0
0
0
0
0
73
0
0
% Q
% Arg:
0
0
0
0
0
0
0
0
10
10
10
0
0
0
0
% R
% Ser:
10
0
10
0
0
0
0
28
55
28
10
0
0
0
0
% S
% Thr:
10
10
0
0
0
0
0
46
0
0
0
0
0
0
0
% T
% Val:
28
0
0
0
10
0
10
0
10
0
10
19
10
0
0
% V
% Trp:
0
0
0
0
0
0
10
0
0
0
0
0
0
0
0
% W
% Tyr:
0
0
0
0
19
0
64
0
0
10
0
0
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _