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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
NPC1
All Species:
10
Human Site:
Y40
Identified Species:
22
UniProt:
O15118
Number Species:
10
Phosphosite Substitution
Charge Score:
-0.2
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
O15118
NP_000262.2
1278
142167
Y40
I
A
Y
G
D
K
R
Y
N
C
E
Y
S
G
P
Chimpanzee
Pan troglodytes
XP_001155285
1277
141871
Y40
I
A
Y
G
D
K
R
Y
N
C
E
Y
S
G
P
Rhesus Macaque
Macaca mulatta
Dog
Lupus familis
Cat
Felis silvestris
Mouse
Mus musculus
O35604
1278
142870
Y41
I
A
T
G
D
K
R
Y
N
C
K
Y
S
G
P
Rat
Rattus norvegicus
Q6T3U3
1331
146397
K40
T
F
Y
E
E
C
G
K
N
P
E
L
S
G
G
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
Chicken
Gallus gallus
XP_419162
1261
140678
Y39
I
A
L
P
K
G
G
Y
D
L
M
Q
E
L
C
Frog
Xenopus laevis
Zebra Danio
Brachydanio rerio
XP_001919958
1164
130467
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
NP_609357
1287
143273
Q48
T
N
D
F
S
H
S
Q
N
C
P
Y
N
G
T
Honey Bee
Apis mellifera
XP_624752
1358
152373
K44
D
R
F
N
M
H
K
K
N
C
P
Y
T
G
P
Nematode Worm
Caenorhab. elegans
Q19127
1383
155438
N42
A
Y
G
P
C
V
T
N
D
T
N
V
E
P
T
Sea Urchin
Strong. purpuratus
XP_780036
1332
147422
L54
D
A
V
T
H
K
S
L
N
C
L
Y
N
K
P
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Baker's Yeast
Sacchar. cerevisiae
Q12200
1170
132626
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
98.9
N.A.
N.A.
N.A.
86.2
39.1
N.A.
N.A.
78
N.A.
63.8
N.A.
45.1
43
28
49.1
Protein Similarity:
100
99.4
N.A.
N.A.
N.A.
93.3
58.3
N.A.
N.A.
87.7
N.A.
76
N.A.
63.2
60.9
47.7
65.5
P-Site Identity:
100
100
N.A.
N.A.
N.A.
86.6
33.3
N.A.
N.A.
20
N.A.
0
N.A.
26.6
33.3
0
40
P-Site Similarity:
100
100
N.A.
N.A.
N.A.
93.3
40
N.A.
N.A.
26.6
N.A.
0
N.A.
33.3
53.3
6.6
46.6
Percent
Protein Identity:
N.A.
N.A.
N.A.
N.A.
32.3
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
N.A.
50.8
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
N.A.
0
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
N.A.
0
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
10
46
0
0
0
0
0
0
0
0
0
0
0
0
0
% A
% Cys:
0
0
0
0
10
10
0
0
0
55
0
0
0
0
10
% C
% Asp:
19
0
10
0
28
0
0
0
19
0
0
0
0
0
0
% D
% Glu:
0
0
0
10
10
0
0
0
0
0
28
0
19
0
0
% E
% Phe:
0
10
10
10
0
0
0
0
0
0
0
0
0
0
0
% F
% Gly:
0
0
10
28
0
10
19
0
0
0
0
0
0
55
10
% G
% His:
0
0
0
0
10
19
0
0
0
0
0
0
0
0
0
% H
% Ile:
37
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% I
% Lys:
0
0
0
0
10
37
10
19
0
0
10
0
0
10
0
% K
% Leu:
0
0
10
0
0
0
0
10
0
10
10
10
0
10
0
% L
% Met:
0
0
0
0
10
0
0
0
0
0
10
0
0
0
0
% M
% Asn:
0
10
0
10
0
0
0
10
64
0
10
0
19
0
0
% N
% Pro:
0
0
0
19
0
0
0
0
0
10
19
0
0
10
46
% P
% Gln:
0
0
0
0
0
0
0
10
0
0
0
10
0
0
0
% Q
% Arg:
0
10
0
0
0
0
28
0
0
0
0
0
0
0
0
% R
% Ser:
0
0
0
0
10
0
19
0
0
0
0
0
37
0
0
% S
% Thr:
19
0
10
10
0
0
10
0
0
10
0
0
10
0
19
% T
% Val:
0
0
10
0
0
10
0
0
0
0
0
10
0
0
0
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
0
10
28
0
0
0
0
37
0
0
0
55
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _