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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: NPC1 All Species: 13.03
Human Site: Y506 Identified Species: 28.67
UniProt: O15118 Number Species: 10
    Phosphosite Substitution
    Charge Score: 0.2
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens O15118 NP_000262.2 1278 142167 Y506 K G D D F F V Y A D Y H T H F
Chimpanzee Pan troglodytes XP_001155285 1277 141871 Y506 K G D D F F V Y A D Y H T H F
Rhesus Macaque Macaca mulatta
Dog Lupus familis
Cat Felis silvestris
Mouse Mus musculus O35604 1278 142870 Y507 V G D D F Y I Y A D Y H T H F
Rat Rattus norvegicus Q6T3U3 1331 146397 L515 T L N G Q T S L V D W K D H F
Wallaby Macropus eugenll
Platypus Ornith. anatinus
Chicken Gallus gallus XP_419162 1261 140678 Y490 V G D D F F V Y A D Y H T H F
Frog Xenopus laevis
Zebra Danio Brachydanio rerio XP_001919958 1164 130467 G438 V F P W L V L G G Y E D S A Y
Tiger Blowfish Takifugu rubipres
Fruit Fly Dros. melanogaster NP_609357 1287 143273 D503 R L D D H D E D N G F N V T Y
Honey Bee Apis mellifera XP_624752 1358 152373 F497 S T T D D D N F T V N Y L D H
Nematode Worm Caenorhab. elegans Q19127 1383 155438 A514 F D Y F S S E A T T D E W M N
Sea Urchin Strong. purpuratus XP_780036 1332 147422 A546 D P S Q F F I A A D F H E H L
Poplar Tree Populus trichocarpa
Maize Zea mays
Rice Oryza sativa
Thale Cress Arabidopsis thaliana
Baker's Yeast Sacchar. cerevisiae Q12200 1170 132626 E443 D L C F R P T E D S T C V I E
Red Bread Mold Neurospora crassa
Conservation
Percent
Protein Identity: 100 98.9 N.A. N.A. N.A. 86.2 39.1 N.A. N.A. 78 N.A. 63.8 N.A. 45.1 43 28 49.1
Protein Similarity: 100 99.4 N.A. N.A. N.A. 93.3 58.3 N.A. N.A. 87.7 N.A. 76 N.A. 63.2 60.9 47.7 65.5
P-Site Identity: 100 100 N.A. N.A. N.A. 80 20 N.A. N.A. 93.3 N.A. 0 N.A. 13.3 6.6 0 40
P-Site Similarity: 100 100 N.A. N.A. N.A. 93.3 33.3 N.A. N.A. 93.3 N.A. 20 N.A. 40 20 0 53.3
Percent
Protein Identity: N.A. N.A. N.A. N.A. 32.3 N.A.
Protein Similarity: N.A. N.A. N.A. N.A. 50.8 N.A.
P-Site Identity: N.A. N.A. N.A. N.A. 0 N.A.
P-Site Similarity: N.A. N.A. N.A. N.A. 0 N.A.
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 0 0 0 0 0 0 0 19 46 0 0 0 0 10 0 % A
% Cys: 0 0 10 0 0 0 0 0 0 0 0 10 0 0 0 % C
% Asp: 19 10 46 55 10 19 0 10 10 55 10 10 10 10 0 % D
% Glu: 0 0 0 0 0 0 19 10 0 0 10 10 10 0 10 % E
% Phe: 10 10 0 19 46 37 0 10 0 0 19 0 0 0 46 % F
% Gly: 0 37 0 10 0 0 0 10 10 10 0 0 0 0 0 % G
% His: 0 0 0 0 10 0 0 0 0 0 0 46 0 55 10 % H
% Ile: 0 0 0 0 0 0 19 0 0 0 0 0 0 10 0 % I
% Lys: 19 0 0 0 0 0 0 0 0 0 0 10 0 0 0 % K
% Leu: 0 28 0 0 10 0 10 10 0 0 0 0 10 0 10 % L
% Met: 0 0 0 0 0 0 0 0 0 0 0 0 0 10 0 % M
% Asn: 0 0 10 0 0 0 10 0 10 0 10 10 0 0 10 % N
% Pro: 0 10 10 0 0 10 0 0 0 0 0 0 0 0 0 % P
% Gln: 0 0 0 10 10 0 0 0 0 0 0 0 0 0 0 % Q
% Arg: 10 0 0 0 10 0 0 0 0 0 0 0 0 0 0 % R
% Ser: 10 0 10 0 10 10 10 0 0 10 0 0 10 0 0 % S
% Thr: 10 10 10 0 0 10 10 0 19 10 10 0 37 10 0 % T
% Val: 28 0 0 0 0 10 28 0 10 10 0 0 19 0 0 % V
% Trp: 0 0 0 10 0 0 0 0 0 0 10 0 10 0 0 % W
% Tyr: 0 0 10 0 0 10 0 37 0 10 37 10 0 0 19 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _