KinATLAS
TranscriptoNET
PhosphoNET
OncoNET
KinaseNET
DrugKiNET
KiNET-AM
Kinetica Online
Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
|
Home
|
Kinexus
|
Contact
|
Credits
Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
NPC1
All Species:
23.03
Human Site:
Y570
Identified Species:
50.67
UniProt:
O15118
Number Species:
10
Phosphosite Substitution
Charge Score:
0
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
O15118
NP_000262.2
1278
142167
Y570
I
T
F
P
V
N
N
Y
Y
N
D
T
E
K
L
Chimpanzee
Pan troglodytes
XP_001155285
1277
141871
Y570
I
T
F
P
V
N
N
Y
Y
N
D
T
E
K
L
Rhesus Macaque
Macaca mulatta
Dog
Lupus familis
Cat
Felis silvestris
Mouse
Mus musculus
O35604
1278
142870
Y571
I
T
F
P
V
N
N
Y
Y
N
D
T
E
R
L
Rat
Rattus norvegicus
Q6T3U3
1331
146397
Y579
I
T
F
S
L
N
N
Y
P
A
D
D
P
R
M
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
Chicken
Gallus gallus
XP_419162
1261
140678
Y554
I
T
L
P
V
N
N
Y
Y
N
D
S
K
K
I
Frog
Xenopus laevis
Zebra Danio
Brachydanio rerio
XP_001919958
1164
130467
E502
S
E
R
S
I
E
D
E
I
D
R
E
S
N
S
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
NP_609357
1287
143273
K567
I
I
L
T
F
L
V
K
N
H
H
N
K
T
D
Honey Bee
Apis mellifera
XP_624752
1358
152373
Y561
L
T
I
L
V
N
N
Y
H
N
K
S
K
L
H
Nematode Worm
Caenorhab. elegans
Q19127
1383
155438
T578
T
I
L
V
T
Q
R
T
E
P
E
I
Q
K
A
Sea Urchin
Strong. purpuratus
XP_780036
1332
147422
Y610
I
T
F
P
V
V
N
Y
I
T
G
D
P
K
L
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Baker's Yeast
Sacchar. cerevisiae
Q12200
1170
132626
V507
L
N
A
H
A
F
V
V
T
L
L
L
T
N
H
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
98.9
N.A.
N.A.
N.A.
86.2
39.1
N.A.
N.A.
78
N.A.
63.8
N.A.
45.1
43
28
49.1
Protein Similarity:
100
99.4
N.A.
N.A.
N.A.
93.3
58.3
N.A.
N.A.
87.7
N.A.
76
N.A.
63.2
60.9
47.7
65.5
P-Site Identity:
100
100
N.A.
N.A.
N.A.
93.3
46.6
N.A.
N.A.
73.3
N.A.
0
N.A.
6.6
40
6.6
60
P-Site Similarity:
100
100
N.A.
N.A.
N.A.
100
66.6
N.A.
N.A.
93.3
N.A.
20
N.A.
20
66.6
20
60
Percent
Protein Identity:
N.A.
N.A.
N.A.
N.A.
32.3
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
N.A.
50.8
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
N.A.
0
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
N.A.
6.6
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
0
10
0
10
0
0
0
0
10
0
0
0
0
10
% A
% Cys:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% C
% Asp:
0
0
0
0
0
0
10
0
0
10
46
19
0
0
10
% D
% Glu:
0
10
0
0
0
10
0
10
10
0
10
10
28
0
0
% E
% Phe:
0
0
46
0
10
10
0
0
0
0
0
0
0
0
0
% F
% Gly:
0
0
0
0
0
0
0
0
0
0
10
0
0
0
0
% G
% His:
0
0
0
10
0
0
0
0
10
10
10
0
0
0
19
% H
% Ile:
64
19
10
0
10
0
0
0
19
0
0
10
0
0
10
% I
% Lys:
0
0
0
0
0
0
0
10
0
0
10
0
28
46
0
% K
% Leu:
19
0
28
10
10
10
0
0
0
10
10
10
0
10
37
% L
% Met:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
10
% M
% Asn:
0
10
0
0
0
55
64
0
10
46
0
10
0
19
0
% N
% Pro:
0
0
0
46
0
0
0
0
10
10
0
0
19
0
0
% P
% Gln:
0
0
0
0
0
10
0
0
0
0
0
0
10
0
0
% Q
% Arg:
0
0
10
0
0
0
10
0
0
0
10
0
0
19
0
% R
% Ser:
10
0
0
19
0
0
0
0
0
0
0
19
10
0
10
% S
% Thr:
10
64
0
10
10
0
0
10
10
10
0
28
10
10
0
% T
% Val:
0
0
0
10
55
10
19
10
0
0
0
0
0
0
0
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
0
0
0
0
0
0
0
64
37
0
0
0
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _