Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.

Updated: 2017 Aug. 1

| Home | Kinexus | Contact | Credits

Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: NPC1 All Species: 16.97
Human Site: Y594 Identified Species: 37.33
UniProt: O15118 Number Species: 10
    Phosphosite Substitution
    Charge Score: 0.1
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens O15118 NP_000262.2 1278 142167 Y594 F I N F V K N Y K N P N L T I
Chimpanzee Pan troglodytes XP_001155285 1277 141871 Y594 F I N F V K N Y K N P N L S I
Rhesus Macaque Macaca mulatta
Dog Lupus familis
Cat Felis silvestris
Mouse Mus musculus O35604 1278 142870 Y595 F I S F V K N Y K N P N L T I
Rat Rattus norvegicus Q6T3U3 1331 146397 N606 E M E S F Q R N T S D K F Q V
Wallaby Macropus eugenll
Platypus Ornith. anatinus
Chicken Gallus gallus XP_419162 1261 140678 Y578 F I N F L K N Y D N P N L T I
Frog Xenopus laevis
Zebra Danio Brachydanio rerio XP_001919958 1164 130467 M521 I V I S Y I I M F V Y I S V A
Tiger Blowfish Takifugu rubipres
Fruit Fly Dros. melanogaster NP_609357 1287 143273 N596 M T N Y T K N N M S Q Y M D I
Honey Bee Apis mellifera XP_624752 1358 152373 K588 M K N W T T T K K P E F M D I
Nematode Worm Caenorhab. elegans Q19127 1383 155438 E601 K F C K E Y R E K S P K V I F
Sea Urchin Strong. purpuratus XP_780036 1332 147422 Y634 Y I D L L K N Y S N P N F T V
Poplar Tree Populus trichocarpa
Maize Zea mays
Rice Oryza sativa
Thale Cress Arabidopsis thaliana
Baker's Yeast Sacchar. cerevisiae Q12200 1170 132626 E526 N R W E E R L E E Y L L D L K
Red Bread Mold Neurospora crassa
Conservation
Percent
Protein Identity: 100 98.9 N.A. N.A. N.A. 86.2 39.1 N.A. N.A. 78 N.A. 63.8 N.A. 45.1 43 28 49.1
Protein Similarity: 100 99.4 N.A. N.A. N.A. 93.3 58.3 N.A. N.A. 87.7 N.A. 76 N.A. 63.2 60.9 47.7 65.5
P-Site Identity: 100 93.3 N.A. N.A. N.A. 93.3 0 N.A. N.A. 86.6 N.A. 0 N.A. 26.6 20 13.3 53.3
P-Site Similarity: 100 100 N.A. N.A. N.A. 100 26.6 N.A. N.A. 93.3 N.A. 6.6 N.A. 46.6 33.3 26.6 80
Percent
Protein Identity: N.A. N.A. N.A. N.A. 32.3 N.A.
Protein Similarity: N.A. N.A. N.A. N.A. 50.8 N.A.
P-Site Identity: N.A. N.A. N.A. N.A. 0 N.A.
P-Site Similarity: N.A. N.A. N.A. N.A. 13.3 N.A.
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 10 % A
% Cys: 0 0 10 0 0 0 0 0 0 0 0 0 0 0 0 % C
% Asp: 0 0 10 0 0 0 0 0 10 0 10 0 10 19 0 % D
% Glu: 10 0 10 10 19 0 0 19 10 0 10 0 0 0 0 % E
% Phe: 37 10 0 37 10 0 0 0 10 0 0 10 19 0 10 % F
% Gly: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % G
% His: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % H
% Ile: 10 46 10 0 0 10 10 0 0 0 0 10 0 10 55 % I
% Lys: 10 10 0 10 0 55 0 10 46 0 0 19 0 0 10 % K
% Leu: 0 0 0 10 19 0 10 0 0 0 10 10 37 10 0 % L
% Met: 19 10 0 0 0 0 0 10 10 0 0 0 19 0 0 % M
% Asn: 10 0 46 0 0 0 55 19 0 46 0 46 0 0 0 % N
% Pro: 0 0 0 0 0 0 0 0 0 10 55 0 0 0 0 % P
% Gln: 0 0 0 0 0 10 0 0 0 0 10 0 0 10 0 % Q
% Arg: 0 10 0 0 0 10 19 0 0 0 0 0 0 0 0 % R
% Ser: 0 0 10 19 0 0 0 0 10 28 0 0 10 10 0 % S
% Thr: 0 10 0 0 19 10 10 0 10 0 0 0 0 37 0 % T
% Val: 0 10 0 0 28 0 0 0 0 10 0 0 10 10 19 % V
% Trp: 0 0 10 10 0 0 0 0 0 0 0 0 0 0 0 % W
% Tyr: 10 0 0 10 10 10 0 46 0 10 10 10 0 0 0 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _