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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: TBX3 All Species: 22.73
Human Site: S644 Identified Species: 41.67
UniProt: O15119 Number Species: 12
    Phosphosite Substitution
    Charge Score: -0.08
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens O15119 NP_005987.3 743 79389 S644 R L R Y S P Y S I P V P V P D
Chimpanzee Pan troglodytes XP_001154426 743 79366 S644 R L R Y S P Y S I P V P V P D
Rhesus Macaque Macaca mulatta XP_001111920 743 79280 S644 R L R Y S P Y S I P V P V P D
Dog Lupus familis XP_534692 710 75612 S611 V G S R G P Y S I F M P V P D
Cat Felis silvestris
Mouse Mus musculus P70324 741 79244 S642 R L R Y S P Y S I P V P V P D
Rat Rattus norvegicus Q7TST9 743 79316 S644 R L R Y S P Y S I P V P V P D
Wallaby Macropus eugenll
Platypus Ornith. anatinus XP_001510506 774 81648 P672 R L R Y N P Y P I P V P L P D
Chicken Gallus gallus O73718 414 46293 D319 K K E N P T S D E S S N E Q T
Frog Xenopus laevis Q6PCL0 691 75547 P594 P F L S S T R P R L R F N P Y
Zebra Danio Brachydanio rerio Q7ZTU9 687 75316 R592 P F L S S S T R P R L R F N P
Tiger Blowfish Takifugu rubipres
Fruit Fly Dros. melanogaster Q24432 972 102538 S850 R P R P A S H S P P T R P I S
Honey Bee Apis mellifera
Nematode Worm Caenorhab. elegans Q19691 423 46979 C328 P L R S P Q F C I P P P I D M
Sea Urchin Strong. purpuratus NP_001123280 649 70697 R554 L N G H P R L R F S P Y H L P
Poplar Tree Populus trichocarpa
Maize Zea mays
Rice Oryza sativa
Thale Cress Arabidopsis thaliana
Baker's Yeast Sacchar. cerevisiae
Red Bread Mold Neurospora crassa
Conservation
Percent
Protein Identity: 100 99.7 99.3 88.2 N.A. 93.6 94.3 N.A. 78.5 48.5 54.5 55.1 N.A. 29.8 N.A. 32.4 39.1
Protein Similarity: 100 99.8 99.5 90 N.A. 95.9 95.9 N.A. 83.3 51.1 66.3 67.2 N.A. 39.2 N.A. 41.8 51.4
P-Site Identity: 100 100 100 53.3 N.A. 100 100 N.A. 80 0 13.3 6.6 N.A. 26.6 N.A. 33.3 0
P-Site Similarity: 100 100 100 60 N.A. 100 100 N.A. 93.3 6.6 13.3 13.3 N.A. 40 N.A. 46.6 6.6
Percent
Protein Identity: N.A. N.A. N.A. N.A. N.A. N.A.
Protein Similarity: N.A. N.A. N.A. N.A. N.A. N.A.
P-Site Identity: N.A. N.A. N.A. N.A. N.A. N.A.
P-Site Similarity: N.A. N.A. N.A. N.A. N.A. N.A.
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 0 0 0 0 8 0 0 0 0 0 0 0 0 0 0 % A
% Cys: 0 0 0 0 0 0 0 8 0 0 0 0 0 0 0 % C
% Asp: 0 0 0 0 0 0 0 8 0 0 0 0 0 8 54 % D
% Glu: 0 0 8 0 0 0 0 0 8 0 0 0 8 0 0 % E
% Phe: 0 16 0 0 0 0 8 0 8 8 0 8 8 0 0 % F
% Gly: 0 8 8 0 8 0 0 0 0 0 0 0 0 0 0 % G
% His: 0 0 0 8 0 0 8 0 0 0 0 0 8 0 0 % H
% Ile: 0 0 0 0 0 0 0 0 62 0 0 0 8 8 0 % I
% Lys: 8 8 0 0 0 0 0 0 0 0 0 0 0 0 0 % K
% Leu: 8 54 16 0 0 0 8 0 0 8 8 0 8 8 0 % L
% Met: 0 0 0 0 0 0 0 0 0 0 8 0 0 0 8 % M
% Asn: 0 8 0 8 8 0 0 0 0 0 0 8 8 8 0 % N
% Pro: 24 8 0 8 24 54 0 16 16 62 16 62 8 62 16 % P
% Gln: 0 0 0 0 0 8 0 0 0 0 0 0 0 8 0 % Q
% Arg: 54 0 62 8 0 8 8 16 8 8 8 16 0 0 0 % R
% Ser: 0 0 8 24 54 16 8 54 0 16 8 0 0 0 8 % S
% Thr: 0 0 0 0 0 16 8 0 0 0 8 0 0 0 8 % T
% Val: 8 0 0 0 0 0 0 0 0 0 47 0 47 0 0 % V
% Trp: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % W
% Tyr: 0 0 0 47 0 0 54 0 0 0 0 8 0 0 8 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _