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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: TBX3 All Species: 25.45
Human Site: Y640 Identified Species: 46.67
UniProt: O15119 Number Species: 12
    Phosphosite Substitution
    Charge Score: -0.08
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens O15119 NP_005987.3 743 79389 Y640 T M R P R L R Y S P Y S I P V
Chimpanzee Pan troglodytes XP_001154426 743 79366 Y640 T M R P R L R Y S P Y S I P V
Rhesus Macaque Macaca mulatta XP_001111920 743 79280 Y640 T M R P R L R Y S P Y S I P V
Dog Lupus familis XP_534692 710 75612 R607 T S S S V G S R G P Y S I F M
Cat Felis silvestris
Mouse Mus musculus P70324 741 79244 Y638 S M R P R L R Y S P Y S I P V
Rat Rattus norvegicus Q7TST9 743 79316 Y640 S M R P R L R Y S P Y S I P V
Wallaby Macropus eugenll
Platypus Ornith. anatinus XP_001510506 774 81648 Y668 A V R P R L R Y N P Y P I P V
Chicken Gallus gallus O73718 414 46293 N315 D E R Q K K E N P T S D E S S
Frog Xenopus laevis Q6PCL0 691 75547 S590 M P R N P F L S S T R P R L R
Zebra Danio Brachydanio rerio Q7ZTU9 687 75316 S588 L S R N P F L S S S T R P R L
Tiger Blowfish Takifugu rubipres
Fruit Fly Dros. melanogaster Q24432 972 102538 P846 S S S P R P R P A S H S P P T
Honey Bee Apis mellifera
Nematode Worm Caenorhab. elegans Q19691 423 46979 S324 S A H H P L R S P Q F C I P P
Sea Urchin Strong. purpuratus NP_001123280 649 70697 H550 T S A I L N G H P R L R F S P
Poplar Tree Populus trichocarpa
Maize Zea mays
Rice Oryza sativa
Thale Cress Arabidopsis thaliana
Baker's Yeast Sacchar. cerevisiae
Red Bread Mold Neurospora crassa
Conservation
Percent
Protein Identity: 100 99.7 99.3 88.2 N.A. 93.6 94.3 N.A. 78.5 48.5 54.5 55.1 N.A. 29.8 N.A. 32.4 39.1
Protein Similarity: 100 99.8 99.5 90 N.A. 95.9 95.9 N.A. 83.3 51.1 66.3 67.2 N.A. 39.2 N.A. 41.8 51.4
P-Site Identity: 100 100 100 33.3 N.A. 93.3 93.3 N.A. 73.3 6.6 13.3 13.3 N.A. 33.3 N.A. 26.6 6.6
P-Site Similarity: 100 100 100 40 N.A. 100 100 N.A. 86.6 13.3 13.3 20 N.A. 53.3 N.A. 40 13.3
Percent
Protein Identity: N.A. N.A. N.A. N.A. N.A. N.A.
Protein Similarity: N.A. N.A. N.A. N.A. N.A. N.A.
P-Site Identity: N.A. N.A. N.A. N.A. N.A. N.A.
P-Site Similarity: N.A. N.A. N.A. N.A. N.A. N.A.
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 8 8 8 0 0 0 0 0 8 0 0 0 0 0 0 % A
% Cys: 0 0 0 0 0 0 0 0 0 0 0 8 0 0 0 % C
% Asp: 8 0 0 0 0 0 0 0 0 0 0 8 0 0 0 % D
% Glu: 0 8 0 0 0 0 8 0 0 0 0 0 8 0 0 % E
% Phe: 0 0 0 0 0 16 0 0 0 0 8 0 8 8 0 % F
% Gly: 0 0 0 0 0 8 8 0 8 0 0 0 0 0 0 % G
% His: 0 0 8 8 0 0 0 8 0 0 8 0 0 0 0 % H
% Ile: 0 0 0 8 0 0 0 0 0 0 0 0 62 0 0 % I
% Lys: 0 0 0 0 8 8 0 0 0 0 0 0 0 0 0 % K
% Leu: 8 0 0 0 8 54 16 0 0 0 8 0 0 8 8 % L
% Met: 8 39 0 0 0 0 0 0 0 0 0 0 0 0 8 % M
% Asn: 0 0 0 16 0 8 0 8 8 0 0 0 0 0 0 % N
% Pro: 0 8 0 54 24 8 0 8 24 54 0 16 16 62 16 % P
% Gln: 0 0 0 8 0 0 0 0 0 8 0 0 0 0 0 % Q
% Arg: 0 0 70 0 54 0 62 8 0 8 8 16 8 8 8 % R
% Ser: 31 31 16 8 0 0 8 24 54 16 8 54 0 16 8 % S
% Thr: 39 0 0 0 0 0 0 0 0 16 8 0 0 0 8 % T
% Val: 0 8 0 0 8 0 0 0 0 0 0 0 0 0 47 % V
% Trp: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % W
% Tyr: 0 0 0 0 0 0 0 47 0 0 54 0 0 0 0 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _