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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
MDM4
All Species:
12.73
Human Site:
Y377
Identified Species:
31.11
UniProt:
O15151
Number Species:
9
Phosphosite Substitution
Charge Score:
0.11
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
O15151
NP_002384.2
490
54864
Y377
V
V
R
P
K
D
A
Y
I
K
K
E
N
S
K
Chimpanzee
Pan troglodytes
XP_514127
490
54873
Y377
V
V
R
P
K
D
V
Y
I
K
K
E
N
S
K
Rhesus Macaque
Macaca mulatta
XP_001097583
479
53952
Y366
V
V
R
P
K
D
V
Y
I
K
K
E
N
S
K
Dog
Lupus familis
XP_536098
519
58173
T406
V
R
P
K
D
V
C
T
K
E
E
K
N
P
K
Cat
Felis silvestris
Mouse
Mus musculus
O35618
489
54974
G376
P
V
V
R
P
K
D
G
Y
L
K
E
E
K
P
Rat
Rattus norvegicus
Q5XIN1
490
55202
G377
P
V
V
R
P
K
D
G
Y
L
K
E
E
K
P
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001507004
516
57467
P403
P
V
V
R
A
R
D
P
Y
A
V
R
D
K
P
Chicken
Gallus gallus
XP_417957
481
54617
Y374
V
G
P
P
K
D
M
Y
V
V
E
N
K
S
H
Frog
Xenopus laevis
Q7ZYI3
475
53387
Q372
S
A
P
M
V
G
V
Q
V
P
E
C
R
S
L
Zebra Danio
Brachydanio rerio
Q7ZUW7
496
55223
D383
D
C
L
R
T
V
S
D
P
V
V
L
P
S
H
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
Honey Bee
Apis mellifera
Nematode Worm
Caenorhab. elegans
Sea Urchin
Strong. purpuratus
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Baker's Yeast
Sacchar. cerevisiae
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
99.5
92.8
88.8
N.A.
84
84.2
N.A.
68.5
59.7
47.1
47.9
N.A.
N.A.
N.A.
N.A.
N.A.
Protein Similarity:
100
99.8
94.4
90.7
N.A.
90.8
90.1
N.A.
78.6
73
65.9
62.2
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Identity:
100
93.3
93.3
20
N.A.
20
20
N.A.
6.6
40
6.6
6.6
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Similarity:
100
93.3
93.3
40
N.A.
20
20
N.A.
13.3
53.3
20
13.3
N.A.
N.A.
N.A.
N.A.
N.A.
Percent
Protein Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
10
0
0
10
0
10
0
0
10
0
0
0
0
0
% A
% Cys:
0
10
0
0
0
0
10
0
0
0
0
10
0
0
0
% C
% Asp:
10
0
0
0
10
40
30
10
0
0
0
0
10
0
0
% D
% Glu:
0
0
0
0
0
0
0
0
0
10
30
50
20
0
0
% E
% Phe:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% F
% Gly:
0
10
0
0
0
10
0
20
0
0
0
0
0
0
0
% G
% His:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
20
% H
% Ile:
0
0
0
0
0
0
0
0
30
0
0
0
0
0
0
% I
% Lys:
0
0
0
10
40
20
0
0
10
30
50
10
10
30
40
% K
% Leu:
0
0
10
0
0
0
0
0
0
20
0
10
0
0
10
% L
% Met:
0
0
0
10
0
0
10
0
0
0
0
0
0
0
0
% M
% Asn:
0
0
0
0
0
0
0
0
0
0
0
10
40
0
0
% N
% Pro:
30
0
30
40
20
0
0
10
10
10
0
0
10
10
30
% P
% Gln:
0
0
0
0
0
0
0
10
0
0
0
0
0
0
0
% Q
% Arg:
0
10
30
40
0
10
0
0
0
0
0
10
10
0
0
% R
% Ser:
10
0
0
0
0
0
10
0
0
0
0
0
0
60
0
% S
% Thr:
0
0
0
0
10
0
0
10
0
0
0
0
0
0
0
% T
% Val:
50
60
30
0
10
20
30
0
20
20
20
0
0
0
0
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
0
0
0
0
0
0
0
40
30
0
0
0
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _