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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
PGRMC2
All Species:
26.97
Human Site:
Y196
Identified Species:
45.64
UniProt:
O15173
Number Species:
13
Phosphosite Substitution
Charge Score:
0.08
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
O15173
NP_006311.1
223
23818
Y196
Q
F
K
E
K
Y
D
Y
V
G
R
L
L
K
P
Chimpanzee
Pan troglodytes
XP_517434
247
26110
Y220
Q
F
K
E
K
Y
D
Y
V
G
R
L
L
K
P
Rhesus Macaque
Macaca mulatta
XP_001082791
247
25994
Y220
Q
F
K
E
K
Y
D
Y
V
G
R
L
L
K
P
Dog
Lupus familis
XP_533292
223
23762
Y196
Q
F
K
E
K
Y
D
Y
V
G
R
L
L
K
P
Cat
Felis silvestris
Mouse
Mus musculus
Q80UU9
217
23316
Y190
Q
F
K
E
K
Y
D
Y
V
G
R
L
L
K
P
Rat
Rattus norvegicus
Q5XIU9
217
23385
Y190
Q
F
K
E
K
Y
D
Y
V
G
R
L
L
K
P
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001513451
172
18645
V146
F
K
E
K
Y
D
Y
V
G
R
L
L
K
P
G
Chicken
Gallus gallus
Q5ZKN2
192
21263
V165
F
T
F
K
Y
H
H
V
G
K
L
L
K
D
G
Frog
Xenopus laevis
NP_001089766
194
21749
V168
F
K
E
K
Y
E
Y
V
G
R
L
L
K
P
G
Zebra Danio
Brachydanio rerio
NP_998269
201
22515
Y174
Q
F
M
E
K
Y
D
Y
V
G
R
L
L
K
P
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
NP_573087
248
27902
L176
Q
F
K
E
K
Y
E
L
V
G
K
L
L
R
K
Honey Bee
Apis mellifera
XP_396615
198
22142
P172
Y
V
G
R
L
L
K
P
G
E
A
P
T
N
Y
Nematode Worm
Caenorhab. elegans
Sea Urchin
Strong. purpuratus
XP_783332
173
19917
D147
M
Q
F
M
E
K
Y
D
Y
I
G
K
L
L
K
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Baker's Yeast
Sacchar. cerevisiae
Q12091
152
16739
A126
L
T
K
E
Q
I
D
A
L
D
E
W
Q
E
H
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
89
88.6
95.9
N.A.
87.8
87.4
N.A.
48.8
55.1
66.8
63.2
N.A.
42.3
41.2
N.A.
45.7
Protein Similarity:
100
89.4
89
96.8
N.A.
89.6
89.2
N.A.
52.9
68.1
78.4
73.5
N.A.
56.8
60.5
N.A.
60.9
P-Site Identity:
100
100
100
100
N.A.
100
100
N.A.
6.6
6.6
6.6
93.3
N.A.
66.6
0
N.A.
6.6
P-Site Similarity:
100
100
100
100
N.A.
100
100
N.A.
20
20
20
93.3
N.A.
86.6
0
N.A.
13.3
Percent
Protein Identity:
N.A.
N.A.
N.A.
N.A.
28.2
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
N.A.
41.2
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
N.A.
20
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
N.A.
40
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
0
0
0
0
0
0
8
0
0
8
0
0
0
0
% A
% Cys:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% C
% Asp:
0
0
0
0
0
8
58
8
0
8
0
0
0
8
0
% D
% Glu:
0
0
15
65
8
8
8
0
0
8
8
0
0
8
0
% E
% Phe:
22
58
15
0
0
0
0
0
0
0
0
0
0
0
0
% F
% Gly:
0
0
8
0
0
0
0
0
29
58
8
0
0
0
22
% G
% His:
0
0
0
0
0
8
8
0
0
0
0
0
0
0
8
% H
% Ile:
0
0
0
0
0
8
0
0
0
8
0
0
0
0
0
% I
% Lys:
0
15
58
22
58
8
8
0
0
8
8
8
22
50
15
% K
% Leu:
8
0
0
0
8
8
0
8
8
0
22
79
65
8
0
% L
% Met:
8
0
8
8
0
0
0
0
0
0
0
0
0
0
0
% M
% Asn:
0
0
0
0
0
0
0
0
0
0
0
0
0
8
0
% N
% Pro:
0
0
0
0
0
0
0
8
0
0
0
8
0
15
50
% P
% Gln:
58
8
0
0
8
0
0
0
0
0
0
0
8
0
0
% Q
% Arg:
0
0
0
8
0
0
0
0
0
15
50
0
0
8
0
% R
% Ser:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% S
% Thr:
0
15
0
0
0
0
0
0
0
0
0
0
8
0
0
% T
% Val:
0
8
0
0
0
0
0
22
58
0
0
0
0
0
0
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
8
0
0
0
% W
% Tyr:
8
0
0
0
22
58
22
50
8
0
0
0
0
0
8
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _