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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: CTDSPL All Species: 26.36
Human Site: S45 Identified Species: 48.33
UniProt: O15194 Number Species: 12
    Phosphosite Substitution
    Charge Score: -0.08
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens O15194 NP_001008393.1 276 31129 S45 R S R S I L S S F F C C F R D
Chimpanzee Pan troglodytes XP_516364 307 34324 S45 R S R S I L S S F F C C F R D
Rhesus Macaque Macaca mulatta XP_001086442 740 81182 S509 R S R S I L S S F F C C F R D
Dog Lupus familis XP_851254 347 38551 S97 R S R G I L S S F F C C F R D
Cat Felis silvestris
Mouse Mus musculus P58465 276 31138 S45 R G R S I L S S F F C C F R D
Rat Rattus norvegicus Q5XIK8 465 52764 A194 I T T S T T S A N G A A Y S N
Wallaby Macropus eugenll
Platypus Ornith. anatinus XP_001521318 361 40295 S131 R R R S I F S S L F C C F R H
Chicken Gallus gallus Q9PTJ6 275 31225 T44 R S R S I F S T L F C C F R D
Frog Xenopus laevis Q801R4 466 52941 T114 S Q V N G E A T A Y E V S Q H
Zebra Danio Brachydanio rerio A4QNX6 460 52428 C173 Q V E E M P T C T A T S R E P
Tiger Blowfish Takifugu rubipres
Fruit Fly Dros. melanogaster Q9VRG7 243 28468 P39 R A F I Q Y Q P V K Y E L F P
Honey Bee Apis mellifera XP_623986 293 32413 R50 P R G R G L L R S L L C C L G
Nematode Worm Caenorhab. elegans
Sea Urchin Strong. purpuratus
Poplar Tree Populus trichocarpa
Maize Zea mays
Rice Oryza sativa
Thale Cress Arabidopsis thaliana
Baker's Yeast Sacchar. cerevisiae Q07949 397 44753 V169 P Q Q G L Y Q V G Q E D M N P
Red Bread Mold Neurospora crassa
Conservation
Percent
Protein Identity: 100 89.5 36.4 74.6 N.A. 96 27.9 N.A. 63.9 88.7 28.1 28.9 N.A. 31.1 59 N.A. N.A.
Protein Similarity: 100 89.9 37.1 77.2 N.A. 97.8 39.1 N.A. 68.4 93.4 39.2 39.7 N.A. 48.1 70.9 N.A. N.A.
P-Site Identity: 100 100 100 93.3 N.A. 93.3 13.3 N.A. 73.3 80 0 0 N.A. 6.6 13.3 N.A. N.A.
P-Site Similarity: 100 100 100 93.3 N.A. 93.3 40 N.A. 73.3 86.6 33.3 20 N.A. 13.3 13.3 N.A. N.A.
Percent
Protein Identity: N.A. N.A. N.A. N.A. 34.2 N.A.
Protein Similarity: N.A. N.A. N.A. N.A. 47.1 N.A.
P-Site Identity: N.A. N.A. N.A. N.A. 0 N.A.
P-Site Similarity: N.A. N.A. N.A. N.A. 13.3 N.A.
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 0 8 0 0 0 0 8 8 8 8 8 8 0 0 0 % A
% Cys: 0 0 0 0 0 0 0 8 0 0 54 62 8 0 0 % C
% Asp: 0 0 0 0 0 0 0 0 0 0 0 8 0 0 47 % D
% Glu: 0 0 8 8 0 8 0 0 0 0 16 8 0 8 0 % E
% Phe: 0 0 8 0 0 16 0 0 39 54 0 0 54 8 0 % F
% Gly: 0 8 8 16 16 0 0 0 8 8 0 0 0 0 8 % G
% His: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 16 % H
% Ile: 8 0 0 8 54 0 0 0 0 0 0 0 0 0 0 % I
% Lys: 0 0 0 0 0 0 0 0 0 8 0 0 0 0 0 % K
% Leu: 0 0 0 0 8 47 8 0 16 8 8 0 8 8 0 % L
% Met: 0 0 0 0 8 0 0 0 0 0 0 0 8 0 0 % M
% Asn: 0 0 0 8 0 0 0 0 8 0 0 0 0 8 8 % N
% Pro: 16 0 0 0 0 8 0 8 0 0 0 0 0 0 24 % P
% Gln: 8 16 8 0 8 0 16 0 0 8 0 0 0 8 0 % Q
% Arg: 62 16 54 8 0 0 0 8 0 0 0 0 8 54 0 % R
% Ser: 8 39 0 54 0 0 62 47 8 0 0 8 8 8 0 % S
% Thr: 0 8 8 0 8 8 8 16 8 0 8 0 0 0 0 % T
% Val: 0 8 8 0 0 0 0 8 8 0 0 8 0 0 0 % V
% Trp: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % W
% Tyr: 0 0 0 0 0 16 0 0 0 8 8 0 8 0 0 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _