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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: CTDSPL All Species: 26.06
Human Site: T100 Identified Species: 47.78
UniProt: O15194 Number Species: 12
    Phosphosite Substitution
    Charge Score: -0.33
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens O15194 NP_001008393.1 276 31129 T100 K Y L L P E V T V L D Y G K K
Chimpanzee Pan troglodytes XP_516364 307 34324 T100 K Y L L P E V T V L D Y G K K
Rhesus Macaque Macaca mulatta XP_001086442 740 81182 T564 K Y L L P E V T V L D Y G K K
Dog Lupus familis XP_851254 347 38551 T152 K Y L L P E V T V L D Y G K K
Cat Felis silvestris
Mouse Mus musculus P58465 276 31138 T100 K Y L L P E V T V L D Y G K K
Rat Rattus norvegicus Q5XIK8 465 52764 K280 R K P A L P L K T R S T P E F
Wallaby Macropus eugenll
Platypus Ornith. anatinus XP_001521318 361 40295 T186 N F L L P E L T L P D Y G K K
Chicken Gallus gallus Q9PTJ6 275 31225 T99 K Y L L P E L T A S D Y G K K
Frog Xenopus laevis Q801R4 466 52941 K281 R K P A L P L K T R S T P E F
Zebra Danio Brachydanio rerio A4QNX6 460 52428 K275 R K P A L P L K T R S T P E F
Tiger Blowfish Takifugu rubipres
Fruit Fly Dros. melanogaster Q9VRG7 243 28468 V84 N A M P R N T V K P G T P H D
Honey Bee Apis mellifera XP_623986 293 32413 R95 R F L L P P V R H Q D M H K K
Nematode Worm Caenorhab. elegans
Sea Urchin Strong. purpuratus
Poplar Tree Populus trichocarpa
Maize Zea mays
Rice Oryza sativa
Thale Cress Arabidopsis thaliana
Baker's Yeast Sacchar. cerevisiae Q07949 397 44753 L221 D T L L P P K L Q E F Q Q K K
Red Bread Mold Neurospora crassa
Conservation
Percent
Protein Identity: 100 89.5 36.4 74.6 N.A. 96 27.9 N.A. 63.9 88.7 28.1 28.9 N.A. 31.1 59 N.A. N.A.
Protein Similarity: 100 89.9 37.1 77.2 N.A. 97.8 39.1 N.A. 68.4 93.4 39.2 39.7 N.A. 48.1 70.9 N.A. N.A.
P-Site Identity: 100 100 100 100 N.A. 100 0 N.A. 66.6 80 0 0 N.A. 0 46.6 N.A. N.A.
P-Site Similarity: 100 100 100 100 N.A. 100 20 N.A. 86.6 86.6 20 20 N.A. 6.6 60 N.A. N.A.
Percent
Protein Identity: N.A. N.A. N.A. N.A. 34.2 N.A.
Protein Similarity: N.A. N.A. N.A. N.A. 47.1 N.A.
P-Site Identity: N.A. N.A. N.A. N.A. 33.3 N.A.
P-Site Similarity: N.A. N.A. N.A. N.A. 33.3 N.A.
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 0 8 0 24 0 0 0 0 8 0 0 0 0 0 0 % A
% Cys: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % C
% Asp: 8 0 0 0 0 0 0 0 0 0 62 0 0 0 8 % D
% Glu: 0 0 0 0 0 54 0 0 0 8 0 0 0 24 0 % E
% Phe: 0 16 0 0 0 0 0 0 0 0 8 0 0 0 24 % F
% Gly: 0 0 0 0 0 0 0 0 0 0 8 0 54 0 0 % G
% His: 0 0 0 0 0 0 0 0 8 0 0 0 8 8 0 % H
% Ile: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % I
% Lys: 47 24 0 0 0 0 8 24 8 0 0 0 0 70 70 % K
% Leu: 0 0 70 70 24 0 39 8 8 39 0 0 0 0 0 % L
% Met: 0 0 8 0 0 0 0 0 0 0 0 8 0 0 0 % M
% Asn: 16 0 0 0 0 8 0 0 0 0 0 0 0 0 0 % N
% Pro: 0 0 24 8 70 39 0 0 0 16 0 0 31 0 0 % P
% Gln: 0 0 0 0 0 0 0 0 8 8 0 8 8 0 0 % Q
% Arg: 31 0 0 0 8 0 0 8 0 24 0 0 0 0 0 % R
% Ser: 0 0 0 0 0 0 0 0 0 8 24 0 0 0 0 % S
% Thr: 0 8 0 0 0 0 8 54 24 0 0 31 0 0 0 % T
% Val: 0 0 0 0 0 0 47 8 39 0 0 0 0 0 0 % V
% Trp: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % W
% Tyr: 0 47 0 0 0 0 0 0 0 0 0 54 0 0 0 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _