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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: KMO All Species: 27.88
Human Site: T147 Identified Species: 43.81
UniProt: O15229 Number Species: 14
    Phosphosite Substitution
    Charge Score: 0.07
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens O15229 NP_003670.2 486 55810 T147 N P E E G M I T V L G S D K V
Chimpanzee Pan troglodytes XP_001160394 490 56253 T147 N P E E G M I T V L G S D K V
Rhesus Macaque Macaca mulatta XP_001093900 458 52405 T147 N P E E G M I T V L G S D K V
Dog Lupus familis XP_537216 492 56859 T162 N P E E G V I T V V G S D E V
Cat Felis silvestris
Mouse Mus musculus Q91WN4 479 54513 T147 I P E E G V L T V L G P D K V
Rat Rattus norvegicus O88867 478 54335 T147 C P E E G I L T M L G P N K V
Wallaby Macropus eugenll
Platypus Ornith. anatinus XP_001514157 469 53167 T147 R P E E G K L T V L G S N D G
Chicken Gallus gallus XP_421897 486 55752 P157 R A V P K D S P S S R S G Q L
Frog Xenopus laevis
Zebra Danio Brachydanio rerio Q1RLY6 474 54228 T155 S P K T G T M T F I G S D G Q
Tiger Blowfish Takifugu rubipres
Fruit Fly Dros. melanogaster A1Z746 465 52863 E168 N L R E G S M E F R N P A K E
Honey Bee Apis mellifera XP_624246 454 52385 L149 D D G K L T I L D T R T R K I
Nematode Worm Caenorhab. elegans Q21795 461 52293 K157 K I P T F G N K S P P Q E H A
Sea Urchin Strong. purpuratus XP_796984 469 53490 H147 D L D N G I L H F T D K N D H
Poplar Tree Populus trichocarpa
Maize Zea mays
Rice Oryza sativa
Thale Cress Arabidopsis thaliana
Baker's Yeast Sacchar. cerevisiae P38169 460 52411 A148 D K Q I C H F A I G E D L K T
Red Bread Mold Neurospora crassa Q7S3C9 507 57299 D162 E S T S N P R D R A R E I E V
Conservation
Percent
Protein Identity: 100 97.7 89.5 80.8 N.A. 78.5 77.1 N.A. 69.9 68.5 N.A. 60 N.A. 43.2 44.4 42.7 50.2
Protein Similarity: 100 98.3 91.5 88.2 N.A. 87.8 87 N.A. 82.5 81.8 N.A. 77.5 N.A. 60.2 61.9 63.7 69.3
P-Site Identity: 100 100 100 80 N.A. 73.3 60 N.A. 60 6.6 N.A. 40 N.A. 26.6 13.3 0 6.6
P-Site Similarity: 100 100 100 100 N.A. 86.6 86.6 N.A. 73.3 20 N.A. 66.6 N.A. 33.3 40 6.6 40
Percent
Protein Identity: N.A. N.A. N.A. N.A. 36.8 37
Protein Similarity: N.A. N.A. N.A. N.A. 55.3 52.4
P-Site Identity: N.A. N.A. N.A. N.A. 6.6 6.6
P-Site Similarity: N.A. N.A. N.A. N.A. 26.6 13.3
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 0 7 0 0 0 0 0 7 0 7 0 0 7 0 7 % A
% Cys: 7 0 0 0 7 0 0 0 0 0 0 0 0 0 0 % C
% Asp: 20 7 7 0 0 7 0 7 7 0 7 7 40 14 0 % D
% Glu: 7 0 47 54 0 0 0 7 0 0 7 7 7 14 7 % E
% Phe: 0 0 0 0 7 0 7 0 20 0 0 0 0 0 0 % F
% Gly: 0 0 7 0 67 7 0 0 0 7 54 0 7 7 7 % G
% His: 0 0 0 0 0 7 0 7 0 0 0 0 0 7 7 % H
% Ile: 7 7 0 7 0 14 34 0 7 7 0 0 7 0 7 % I
% Lys: 7 7 7 7 7 7 0 7 0 0 0 7 0 54 0 % K
% Leu: 0 14 0 0 7 0 27 7 0 40 0 0 7 0 7 % L
% Met: 0 0 0 0 0 20 14 0 7 0 0 0 0 0 0 % M
% Asn: 34 0 0 7 7 0 7 0 0 0 7 0 20 0 0 % N
% Pro: 0 54 7 7 0 7 0 7 0 7 7 20 0 0 0 % P
% Gln: 0 0 7 0 0 0 0 0 0 0 0 7 0 7 7 % Q
% Arg: 14 0 7 0 0 0 7 0 7 7 20 0 7 0 0 % R
% Ser: 7 7 0 7 0 7 7 0 14 7 0 47 0 0 0 % S
% Thr: 0 0 7 14 0 14 0 54 0 14 0 7 0 0 7 % T
% Val: 0 0 7 0 0 14 0 0 40 7 0 0 0 0 47 % V
% Trp: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % W
% Tyr: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _