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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: KMO All Species: 35.15
Human Site: Y185 Identified Species: 55.24
UniProt: O15229 Number Species: 14
    Phosphosite Substitution
    Charge Score: 0
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens O15229 NP_003670.2 486 55810 Y185 M K K P R F D Y S Q Q Y I P H
Chimpanzee Pan troglodytes XP_001160394 490 56253 Y185 M K K P R F D Y S Q Q Y I P H
Rhesus Macaque Macaca mulatta XP_001093900 458 52405 Y185 M K K P R F D Y S Q Q Y I P H
Dog Lupus familis XP_537216 492 56859 Y200 M K K P R F D Y S Q Q Y I P H
Cat Felis silvestris
Mouse Mus musculus Q91WN4 479 54513 Y185 M K K P R F D Y T Q Q Y I P H
Rat Rattus norvegicus O88867 478 54335 Y185 M K K P R F D Y S Q Q Y I P H
Wallaby Macropus eugenll
Platypus Ornith. anatinus XP_001514157 469 53167 F185 L K Q P R F N F S Q Q Y I S H
Chicken Gallus gallus XP_421897 486 55752 Y195 M R Q T R F N Y S H E Y I P H
Frog Xenopus laevis
Zebra Danio Brachydanio rerio Q1RLY6 474 54228 Y193 L R Q S R F N Y S Q T Y I P H
Tiger Blowfish Takifugu rubipres
Fruit Fly Dros. melanogaster A1Z746 465 52863 Y206 V R L P G F N Y S Q E Y I E T
Honey Bee Apis mellifera XP_624246 454 52385 S187 K K P R F N C S Q T Y I E H G
Nematode Worm Caenorhab. elegans Q21795 461 52293 F195 M T I P R F D F S Q E Y I E H
Sea Urchin Strong. purpuratus XP_796984 469 53490 F185 M R K T L I D F S Q E Y I P H
Poplar Tree Populus trichocarpa
Maize Zea mays
Rice Oryza sativa
Thale Cress Arabidopsis thaliana
Baker's Yeast Sacchar. cerevisiae P38169 460 52411 F186 Q R K V E M D F S Q E Y M N L
Red Bread Mold Neurospora crassa Q7S3C9 507 57299 Y200 R M D Y Q Q E Y I D T L W C E
Conservation
Percent
Protein Identity: 100 97.7 89.5 80.8 N.A. 78.5 77.1 N.A. 69.9 68.5 N.A. 60 N.A. 43.2 44.4 42.7 50.2
Protein Similarity: 100 98.3 91.5 88.2 N.A. 87.8 87 N.A. 82.5 81.8 N.A. 77.5 N.A. 60.2 61.9 63.7 69.3
P-Site Identity: 100 100 100 100 N.A. 93.3 100 N.A. 66.6 60 N.A. 60 N.A. 46.6 6.6 66.6 60
P-Site Similarity: 100 100 100 100 N.A. 100 100 N.A. 93.3 86.6 N.A. 86.6 N.A. 73.3 6.6 80 80
Percent
Protein Identity: N.A. N.A. N.A. N.A. 36.8 37
Protein Similarity: N.A. N.A. N.A. N.A. 55.3 52.4
P-Site Identity: N.A. N.A. N.A. N.A. 33.3 6.6
P-Site Similarity: N.A. N.A. N.A. N.A. 60 20
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % A
% Cys: 0 0 0 0 0 0 7 0 0 0 0 0 0 7 0 % C
% Asp: 0 0 7 0 0 0 60 0 0 7 0 0 0 0 0 % D
% Glu: 0 0 0 0 7 0 7 0 0 0 34 0 7 14 7 % E
% Phe: 0 0 0 0 7 74 0 27 0 0 0 0 0 0 0 % F
% Gly: 0 0 0 0 7 0 0 0 0 0 0 0 0 0 7 % G
% His: 0 0 0 0 0 0 0 0 0 7 0 0 0 7 74 % H
% Ile: 0 0 7 0 0 7 0 0 7 0 0 7 80 0 0 % I
% Lys: 7 54 54 0 0 0 0 0 0 0 0 0 0 0 0 % K
% Leu: 14 0 7 0 7 0 0 0 0 0 0 7 0 0 7 % L
% Met: 60 7 0 0 0 7 0 0 0 0 0 0 7 0 0 % M
% Asn: 0 0 0 0 0 7 27 0 0 0 0 0 0 7 0 % N
% Pro: 0 0 7 60 0 0 0 0 0 0 0 0 0 60 0 % P
% Gln: 7 0 20 0 7 7 0 0 7 80 47 0 0 0 0 % Q
% Arg: 7 34 0 7 67 0 0 0 0 0 0 0 0 0 0 % R
% Ser: 0 0 0 7 0 0 0 7 80 0 0 0 0 7 0 % S
% Thr: 0 7 0 14 0 0 0 0 7 7 14 0 0 0 7 % T
% Val: 7 0 0 7 0 0 0 0 0 0 0 0 0 0 0 % V
% Trp: 0 0 0 0 0 0 0 0 0 0 0 0 7 0 0 % W
% Tyr: 0 0 0 7 0 0 0 67 0 0 7 87 0 0 0 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _