Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.

Updated: 2017 Aug. 1

| Home | Kinexus | Contact | Credits

Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: LEPROT All Species: 13.03
Human Site: S64 Identified Species: 28.67
UniProt: O15243 Number Species: 10
    Phosphosite Substitution
    Charge Score: 0
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens O15243 NP_059996.1 131 14254 S64 Y D S D A T S S A C R E L A Y
Chimpanzee Pan troglodytes XP_528101 194 20282 N127 D D T D A M S N A C K E L A I
Rhesus Macaque Macaca mulatta XP_001091320 124 13818 F66 C R E L A Y F F T T G I V V S
Dog Lupus familis XP_865019 110 12161 F61 T G I V V S A F G F P V I L A
Cat Felis silvestris
Mouse Mus musculus O89013 131 14297 S64 Y D S D A T S S A C R E L A Y
Rat Rattus norvegicus Q9JLS8 131 14301 S64 Y D S D A T S S A C R E L A Y
Wallaby Macropus eugenll
Platypus Ornith. anatinus XP_001515248 260 28693 N193 D D S D S G S N A C R E L A Y
Chicken Gallus gallus NP_001007959 131 14370 S64 D D S D A A S S A C R E L A Y
Frog Xenopus laevis
Zebra Danio Brachydanio rerio NP_001002390 131 14174 N64 E D S D S A S N A C K E L A V
Tiger Blowfish Takifugu rubipres NP_001129622 131 14244 N64 D D T D S A S N A C K E L A I
Fruit Fly Dros. melanogaster
Honey Bee Apis mellifera
Nematode Worm Caenorhab. elegans Q18319 132 14098 A64 E D M T G T N A C I E L A L F
Sea Urchin Strong. purpuratus
Poplar Tree Populus trichocarpa
Maize Zea mays
Rice Oryza sativa
Thale Cress Arabidopsis thaliana
Baker's Yeast Sacchar. cerevisiae
Red Bread Mold Neurospora crassa
Conservation
Percent
Protein Identity: 100 45.8 79.3 81.6 N.A. 94.6 96.9 N.A. 45.3 87.7 N.A. 68.6 67.9 N.A. N.A. 46.9 N.A.
Protein Similarity: 100 54.6 81.6 83.2 N.A. 97.7 99.2 N.A. 47.6 93.1 N.A. 80.1 80.1 N.A. N.A. 65.1 N.A.
P-Site Identity: 100 60 6.6 0 N.A. 100 100 N.A. 73.3 86.6 N.A. 60 53.3 N.A. N.A. 13.3 N.A.
P-Site Similarity: 100 80 13.3 20 N.A. 100 100 N.A. 86.6 86.6 N.A. 80 80 N.A. N.A. 33.3 N.A.
Percent
Protein Identity: N.A. N.A. N.A. N.A. N.A. N.A.
Protein Similarity: N.A. N.A. N.A. N.A. N.A. N.A.
P-Site Identity: N.A. N.A. N.A. N.A. N.A. N.A.
P-Site Similarity: N.A. N.A. N.A. N.A. N.A. N.A.
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 0 0 0 0 55 28 10 10 73 0 0 0 10 73 10 % A
% Cys: 10 0 0 0 0 0 0 0 10 73 0 0 0 0 0 % C
% Asp: 37 82 0 73 0 0 0 0 0 0 0 0 0 0 0 % D
% Glu: 19 0 10 0 0 0 0 0 0 0 10 73 0 0 0 % E
% Phe: 0 0 0 0 0 0 10 19 0 10 0 0 0 0 10 % F
% Gly: 0 10 0 0 10 10 0 0 10 0 10 0 0 0 0 % G
% His: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % H
% Ile: 0 0 10 0 0 0 0 0 0 10 0 10 10 0 19 % I
% Lys: 0 0 0 0 0 0 0 0 0 0 28 0 0 0 0 % K
% Leu: 0 0 0 10 0 0 0 0 0 0 0 10 73 19 0 % L
% Met: 0 0 10 0 0 10 0 0 0 0 0 0 0 0 0 % M
% Asn: 0 0 0 0 0 0 10 37 0 0 0 0 0 0 0 % N
% Pro: 0 0 0 0 0 0 0 0 0 0 10 0 0 0 0 % P
% Gln: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % Q
% Arg: 0 10 0 0 0 0 0 0 0 0 46 0 0 0 0 % R
% Ser: 0 0 55 0 28 10 73 37 0 0 0 0 0 0 10 % S
% Thr: 10 0 19 10 0 37 0 0 10 10 0 0 0 0 0 % T
% Val: 0 0 0 10 10 0 0 0 0 0 0 10 10 10 10 % V
% Trp: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % W
% Tyr: 28 0 0 0 0 10 0 0 0 0 0 0 0 0 46 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _