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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
SLC22A2
All Species:
17.27
Human Site:
T489
Identified Species:
38
UniProt:
O15244
Number Species:
10
Phosphosite Substitution
Charge Score:
0.2
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
O15244
NP_003049.1
555
62565
T489
P
F
L
V
Y
R
L
T
N
I
W
L
E
L
P
Chimpanzee
Pan troglodytes
XP_518840
555
62506
T489
P
F
L
V
Y
R
L
T
N
I
W
L
E
L
P
Rhesus Macaque
Macaca mulatta
XP_001098823
554
61424
M488
P
F
I
V
F
R
L
M
E
V
W
Q
A
L
P
Dog
Lupus familis
XP_533466
533
59144
T488
P
F
L
V
Y
R
L
T
N
I
W
H
E
L
P
Cat
Felis silvestris
Mouse
Mus musculus
O70577
553
61812
T489
P
F
L
V
Y
R
L
T
D
I
W
L
E
F
P
Rat
Rattus norvegicus
Q9R0W2
555
62324
T489
P
F
L
V
Y
R
L
T
D
I
W
M
E
F
P
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
Chicken
Gallus gallus
XP_419621
554
62101
A488
P
F
I
V
Y
R
L
A
E
L
W
H
E
L
P
Frog
Xenopus laevis
Q66J54
558
62434
E485
P
L
V
K
I
L
G
E
Y
Y
P
F
L
P
L
Zebra Danio
Brachydanio rerio
Q6NYN7
560
61953
D488
P
M
V
L
L
L
G
D
D
Y
P
W
I
P
G
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
Q9VCA2
548
60985
E479
P
Y
L
K
L
L
G
E
I
W
R
P
L
P
L
Honey Bee
Apis mellifera
Nematode Worm
Caenorhab. elegans
Q9U539
585
65444
K501
P
H
I
V
N
L
G
K
I
V
K
I
L
P
L
Sea Urchin
Strong. purpuratus
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Baker's Yeast
Sacchar. cerevisiae
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
96.4
67.2
81.2
N.A.
83.4
82.1
N.A.
N.A.
69.3
32.9
31.4
N.A.
35.1
N.A.
29.2
N.A.
Protein Similarity:
100
97.1
80
87.3
N.A.
90.2
89.5
N.A.
N.A.
80.7
51.9
50.7
N.A.
56.2
N.A.
48.2
N.A.
P-Site Identity:
100
100
53.3
93.3
N.A.
86.6
80
N.A.
N.A.
66.6
6.6
6.6
N.A.
13.3
N.A.
13.3
N.A.
P-Site Similarity:
100
100
73.3
93.3
N.A.
93.3
93.3
N.A.
N.A.
80
13.3
26.6
N.A.
20
N.A.
33.3
N.A.
Percent
Protein Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
0
0
0
0
0
0
10
0
0
0
0
10
0
0
% A
% Cys:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% C
% Asp:
0
0
0
0
0
0
0
10
28
0
0
0
0
0
0
% D
% Glu:
0
0
0
0
0
0
0
19
19
0
0
0
55
0
0
% E
% Phe:
0
64
0
0
10
0
0
0
0
0
0
10
0
19
0
% F
% Gly:
0
0
0
0
0
0
37
0
0
0
0
0
0
0
10
% G
% His:
0
10
0
0
0
0
0
0
0
0
0
19
0
0
0
% H
% Ile:
0
0
28
0
10
0
0
0
19
46
0
10
10
0
0
% I
% Lys:
0
0
0
19
0
0
0
10
0
0
10
0
0
0
0
% K
% Leu:
0
10
55
10
19
37
64
0
0
10
0
28
28
46
28
% L
% Met:
0
10
0
0
0
0
0
10
0
0
0
10
0
0
0
% M
% Asn:
0
0
0
0
10
0
0
0
28
0
0
0
0
0
0
% N
% Pro:
100
0
0
0
0
0
0
0
0
0
19
10
0
37
64
% P
% Gln:
0
0
0
0
0
0
0
0
0
0
0
10
0
0
0
% Q
% Arg:
0
0
0
0
0
64
0
0
0
0
10
0
0
0
0
% R
% Ser:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% S
% Thr:
0
0
0
0
0
0
0
46
0
0
0
0
0
0
0
% T
% Val:
0
0
19
73
0
0
0
0
0
19
0
0
0
0
0
% V
% Trp:
0
0
0
0
0
0
0
0
0
10
64
10
0
0
0
% W
% Tyr:
0
10
0
0
55
0
0
0
10
19
0
0
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _