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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: SLC22A1 All Species: 14.55
Human Site: S108 Identified Species: 32
UniProt: O15245 Number Species: 10
    Phosphosite Substitution
    Charge Score: 0
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens O15245 NP_003048.1 554 61188 S108 S C V D P L A S L A T N R S H
Chimpanzee Pan troglodytes XP_527554 552 60658 L106 A L S C V D P L A S L A T N R
Rhesus Macaque Macaca mulatta XP_001098823 554 61424 S108 S C V D P L A S L A T N R S H
Dog Lupus familis XP_850971 554 60920 G108 G C V D P L A G L A A N R S H
Cat Felis silvestris
Mouse Mus musculus O08966 556 61503 S109 D C V D P L S S L A A N R S H
Rat Rattus norvegicus Q63089 556 61523 S109 D C V D P L S S L V A N R S Q
Wallaby Macropus eugenll
Platypus Ornith. anatinus
Chicken Gallus gallus XP_419622 554 62301 S108 S C T D P L G S L V G N W S S
Frog Xenopus laevis Q66J52 552 61646 L108 D L E T E P C L D G W V Y D H
Zebra Danio Brachydanio rerio NP_998315 562 62704 N110 E N P D G D F N Q S Q L S V M
Tiger Blowfish Takifugu rubipres
Fruit Fly Dros. melanogaster Q9VCA2 548 60985 R109 C S S Y V Y D R S K Y L N S A
Honey Bee Apis mellifera
Nematode Worm Caenorhab. elegans Q9U539 585 65444 D114 A F T S A P V D T Y S D R I S
Sea Urchin Strong. purpuratus
Poplar Tree Populus trichocarpa
Maize Zea mays
Rice Oryza sativa
Thale Cress Arabidopsis thaliana
Baker's Yeast Sacchar. cerevisiae
Red Bread Mold Neurospora crassa
Conservation
Percent
Protein Identity: 100 94.9 91.1 79.9 N.A. 77.8 78 N.A. N.A. 63.9 33.3 47.3 N.A. 34.4 N.A. 27.6 N.A.
Protein Similarity: 100 95.8 93.5 86.8 N.A. 88.3 87.9 N.A. N.A. 77.4 52.3 67.2 N.A. 53.7 N.A. 46.8 N.A.
P-Site Identity: 100 0 100 80 N.A. 80 66.6 N.A. N.A. 60 6.6 6.6 N.A. 6.6 N.A. 6.6 N.A.
P-Site Similarity: 100 20 100 80 N.A. 86.6 73.3 N.A. N.A. 60 6.6 20 N.A. 6.6 N.A. 26.6 N.A.
Percent
Protein Identity: N.A. N.A. N.A. N.A. N.A. N.A.
Protein Similarity: N.A. N.A. N.A. N.A. N.A. N.A.
P-Site Identity: N.A. N.A. N.A. N.A. N.A. N.A.
P-Site Similarity: N.A. N.A. N.A. N.A. N.A. N.A.
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 19 0 0 0 10 0 28 0 10 37 28 10 0 0 10 % A
% Cys: 10 55 0 10 0 0 10 0 0 0 0 0 0 0 0 % C
% Asp: 28 0 0 64 0 19 10 10 10 0 0 10 0 10 0 % D
% Glu: 10 0 10 0 10 0 0 0 0 0 0 0 0 0 0 % E
% Phe: 0 10 0 0 0 0 10 0 0 0 0 0 0 0 0 % F
% Gly: 10 0 0 0 10 0 10 10 0 10 10 0 0 0 0 % G
% His: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 46 % H
% Ile: 0 0 0 0 0 0 0 0 0 0 0 0 0 10 0 % I
% Lys: 0 0 0 0 0 0 0 0 0 10 0 0 0 0 0 % K
% Leu: 0 19 0 0 0 55 0 19 55 0 10 19 0 0 0 % L
% Met: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 10 % M
% Asn: 0 10 0 0 0 0 0 10 0 0 0 55 10 10 0 % N
% Pro: 0 0 10 0 55 19 10 0 0 0 0 0 0 0 0 % P
% Gln: 0 0 0 0 0 0 0 0 10 0 10 0 0 0 10 % Q
% Arg: 0 0 0 0 0 0 0 10 0 0 0 0 55 0 10 % R
% Ser: 28 10 19 10 0 0 19 46 10 19 10 0 10 64 19 % S
% Thr: 0 0 19 10 0 0 0 0 10 0 19 0 10 0 0 % T
% Val: 0 0 46 0 19 0 10 0 0 19 0 10 0 10 0 % V
% Trp: 0 0 0 0 0 0 0 0 0 0 10 0 10 0 0 % W
% Tyr: 0 0 0 10 0 10 0 0 0 10 10 0 10 0 0 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _