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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
NPHP1
All Species:
5.45
Human Site:
S219
Identified Species:
17.14
UniProt:
O15259
Number Species:
7
Phosphosite Substitution
Charge Score:
-0.14
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
O15259
NP_000263.2
732
83299
S219
E
E
E
E
G
Q
E
S
S
E
E
G
S
E
E
Chimpanzee
Pan troglodytes
XP_515684
733
83523
S220
E
E
E
G
Q
E
S
S
E
E
G
S
E
E
D
Rhesus Macaque
Macaca mulatta
Dog
Lupus familis
XP_532954
694
78936
T181
Y
I
A
V
G
D
F
T
A
Q
Q
A
G
D
L
Cat
Felis silvestris
Mouse
Mus musculus
Q9QY53
687
77017
L174
A
A
Q
Q
T
G
D
L
T
F
K
K
G
D
V
Rat
Rattus norvegicus
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
Chicken
Gallus gallus
XP_419298
726
82217
R211
G
E
R
G
L
V
P
R
T
Y
L
A
V
H
N
Frog
Xenopus laevis
NP_001085200
683
78385
L174
Q
A
Q
Q
K
D
D
L
T
F
K
K
G
Q
V
Zebra Danio
Brachydanio rerio
NP_001070638
667
74543
S162
A
A
A
A
E
Q
G
S
A
S
Y
I
T
L
S
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
Honey Bee
Apis mellifera
Nematode Worm
Caenorhab. elegans
Sea Urchin
Strong. purpuratus
XP_782288
622
72000
P117
E
E
E
E
N
F
K
P
P
D
E
G
M
D
L
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Baker's Yeast
Sacchar. cerevisiae
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
97.9
N.A.
78.5
N.A.
72.6
N.A.
N.A.
N.A.
58.8
55.1
43.5
N.A.
N.A.
N.A.
N.A.
36.3
Protein Similarity:
100
98.9
N.A.
85.5
N.A.
83.4
N.A.
N.A.
N.A.
76.2
72.4
63.6
N.A.
N.A.
N.A.
N.A.
55.3
P-Site Identity:
100
40
N.A.
6.6
N.A.
0
N.A.
N.A.
N.A.
6.6
0
13.3
N.A.
N.A.
N.A.
N.A.
40
P-Site Similarity:
100
53.3
N.A.
40
N.A.
40
N.A.
N.A.
N.A.
13.3
46.6
26.6
N.A.
N.A.
N.A.
N.A.
60
Percent
Protein Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
25
38
25
13
0
0
0
0
25
0
0
25
0
0
0
% A
% Cys:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% C
% Asp:
0
0
0
0
0
25
25
0
0
13
0
0
0
38
13
% D
% Glu:
38
50
38
25
13
13
13
0
13
25
25
0
13
25
13
% E
% Phe:
0
0
0
0
0
13
13
0
0
25
0
0
0
0
0
% F
% Gly:
13
0
0
25
25
13
13
0
0
0
13
25
38
0
0
% G
% His:
0
0
0
0
0
0
0
0
0
0
0
0
0
13
0
% H
% Ile:
0
13
0
0
0
0
0
0
0
0
0
13
0
0
0
% I
% Lys:
0
0
0
0
13
0
13
0
0
0
25
25
0
0
0
% K
% Leu:
0
0
0
0
13
0
0
25
0
0
13
0
0
13
25
% L
% Met:
0
0
0
0
0
0
0
0
0
0
0
0
13
0
0
% M
% Asn:
0
0
0
0
13
0
0
0
0
0
0
0
0
0
13
% N
% Pro:
0
0
0
0
0
0
13
13
13
0
0
0
0
0
0
% P
% Gln:
13
0
25
25
13
25
0
0
0
13
13
0
0
13
0
% Q
% Arg:
0
0
13
0
0
0
0
13
0
0
0
0
0
0
0
% R
% Ser:
0
0
0
0
0
0
13
38
13
13
0
13
13
0
13
% S
% Thr:
0
0
0
0
13
0
0
13
38
0
0
0
13
0
0
% T
% Val:
0
0
0
13
0
13
0
0
0
0
0
0
13
0
25
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
13
0
0
0
0
0
0
0
0
13
13
0
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _