KinATLAS
TranscriptoNET
PhosphoNET
OncoNET
KinaseNET
DrugKiNET
KiNET-AM
Kinetica Online
Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
|
Home
|
Kinexus
|
Contact
|
Credits
Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
SPTLC1
All Species:
43.94
Human Site:
S443
Identified Species:
69.05
UniProt:
O15269
Number Species:
14
Phosphosite Substitution
Charge Score:
0
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
O15269
NP_006406.1
473
52744
S443
E
K
C
L
P
P
P
S
I
R
V
V
V
T
V
Chimpanzee
Pan troglodytes
XP_520127
343
38184
V316
L
P
P
P
S
I
R
V
V
V
T
V
E
Q
T
Rhesus Macaque
Macaca mulatta
XP_001102219
486
54533
S456
E
K
C
L
P
P
P
S
I
R
V
V
V
T
V
Dog
Lupus familis
XP_541308
473
52782
S443
E
K
C
L
P
P
P
S
I
R
V
V
V
T
V
Cat
Felis silvestris
Mouse
Mus musculus
O35704
473
52472
S443
E
K
C
L
P
P
P
S
I
R
V
V
V
T
V
Rat
Rattus norvegicus
NP_001101876
473
52530
S443
E
K
C
L
P
P
P
S
I
R
V
V
V
T
V
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
Chicken
Gallus gallus
XP_423815
576
63994
S546
E
K
C
L
P
S
P
S
I
R
V
V
V
T
V
Frog
Xenopus laevis
NP_001084963
472
53096
S442
E
K
F
L
P
P
P
S
I
R
V
V
V
T
V
Zebra Danio
Brachydanio rerio
NP_001018307
472
53307
S442
E
R
F
L
P
P
P
S
I
R
V
V
V
T
V
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
NP_610842
468
52515
S439
E
R
Q
P
V
R
P
S
I
R
I
A
V
N
R
Honey Bee
Apis mellifera
XP_624768
467
52785
S436
E
K
N
L
P
R
P
S
L
R
L
C
I
S
T
Nematode Worm
Caenorhab. elegans
NP_001021978
458
52066
S430
E
L
F
K
I
R
P
S
I
R
V
M
F
Q
H
Sea Urchin
Strong. purpuratus
XP_001178756
460
51271
S424
E
A
F
L
P
P
P
S
I
R
I
A
V
N
V
Poplar Tree
Populus trichocarpa
Maize
Zea mays
NP_001147940
485
52439
G452
D
R
C
K
L
P
I
G
I
R
L
F
V
S
A
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Baker's Yeast
Sacchar. cerevisiae
P25045
558
62189
S524
E
T
L
P
I
V
P
S
L
K
I
C
C
N
A
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
71.6
77.7
94.9
N.A.
91.7
91.3
N.A.
N.A.
71.1
86.8
84.1
N.A.
49.6
46.5
47.7
54.1
Protein Similarity:
100
72
80.8
98.3
N.A.
96.6
96.6
N.A.
N.A.
77
92.1
91.5
N.A.
67.8
68.7
66.5
73.5
P-Site Identity:
100
6.6
100
100
N.A.
100
100
N.A.
N.A.
93.3
93.3
86.6
N.A.
40
46.6
40
66.6
P-Site Similarity:
100
13.3
100
100
N.A.
100
100
N.A.
N.A.
93.3
93.3
93.3
N.A.
53.3
73.3
46.6
73.3
Percent
Protein Identity:
N.A.
44.9
N.A.
N.A.
32.6
N.A.
Protein Similarity:
N.A.
63
N.A.
N.A.
48.7
N.A.
P-Site Identity:
N.A.
33.3
N.A.
N.A.
20
N.A.
P-Site Similarity:
N.A.
60
N.A.
N.A.
40
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
7
0
0
0
0
0
0
0
0
0
14
0
0
14
% A
% Cys:
0
0
47
0
0
0
0
0
0
0
0
14
7
0
0
% C
% Asp:
7
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% D
% Glu:
87
0
0
0
0
0
0
0
0
0
0
0
7
0
0
% E
% Phe:
0
0
27
0
0
0
0
0
0
0
0
7
7
0
0
% F
% Gly:
0
0
0
0
0
0
0
7
0
0
0
0
0
0
0
% G
% His:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
7
% H
% Ile:
0
0
0
0
14
7
7
0
80
0
20
0
7
0
0
% I
% Lys:
0
54
0
14
0
0
0
0
0
7
0
0
0
0
0
% K
% Leu:
7
7
7
67
7
0
0
0
14
0
14
0
0
0
0
% L
% Met:
0
0
0
0
0
0
0
0
0
0
0
7
0
0
0
% M
% Asn:
0
0
7
0
0
0
0
0
0
0
0
0
0
20
0
% N
% Pro:
0
7
7
20
67
60
87
0
0
0
0
0
0
0
0
% P
% Gln:
0
0
7
0
0
0
0
0
0
0
0
0
0
14
0
% Q
% Arg:
0
20
0
0
0
20
7
0
0
87
0
0
0
0
7
% R
% Ser:
0
0
0
0
7
7
0
87
0
0
0
0
0
14
0
% S
% Thr:
0
7
0
0
0
0
0
0
0
0
7
0
0
54
14
% T
% Val:
0
0
0
0
7
7
0
7
7
7
60
60
74
0
60
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _